Posted by Miguel (4.40.20.137) on January 19, 2001 at 15:47:10:
Just read an article that suggests new findings regarding
attacks of Migraine and CH. Where common knowledge in so
far has only focused at the root of the ailment being
the blood vessel, 5-HT interactions, new studies indicate
that such may not be the cause. It appears that the vasodilatory
effect and all those 5-HT-related responses are the result
of the misfiring (misbehaving) of the nerves running parallel
to those vessels. Nobody has come forth yet with a theory
regarding what causes such incidence of nerve-derived
problems. However, it has been noted that our best
RX in so far has just been lucky in affecting the problem.
I imagine that might explain why sometimes these drugs
work, and sometimes they don't. Also, why surgery
solutions might be so temporary.
As I recall, it was sometime ago that I was discusing with someone
in this board the "screwy myelin sheath" theory. This perhaps
was right track.
From the biological point of view, it makes sense in the
way that ion leakage may affect the homeostasis of a vessel.
This in term affects other autoregulating mechanisms that
are triggered to compensate the dysfunction. Just a thought
that came to mind, perhaps such might be answer of why
verapamil is somewhat efffective, at least temporally for some.
Verapamil, a Ca++ channel blocker may play a role in
the electrophisiological balance of the cortex' vasculature.
Any thoughts?
Miguel