Thanks for sharing, interesting article!

Thanks Peter.  Also interesting reading.

Preventative use reduced mean attack frequency from 4.5 attacks every 24 hours to 2.6 after treatment

A twelve-month open-label study in the March issue of the journal Neurology, reports that electroCore’s non-invasive Vagus Nerve stimulation (nVNS) device, gammaCore, is practical and effective as an acute and preventative treatment in cluster headache. Seventy-nine percent of patients who completed the trial (15 out of 19) reported an overall improvement in their condition.

The study into cluster headache, which is considered to be one of the most painful conditions known to medical science, was led by Professor Peter Goadsby and was conducted at the Royal Free Hospital in London and the Beaumont Hospital in Dublin.

Of the 25 patients enrolled 19 patients completed the study; 11 of whom had chronic cluster headache, and eight were classified as episodic. Seven of the chronic cluster patients were drug refractory – having previously failed to respond to at least five different preventative agents. Of all acute attacks treated, 47% were aborted within an average of 11 minutes. Ten patients reduced their acute use of high flow oxygen by 55% with nine reducing triptan use by 48%. Preventative use of the gammaCore device resulted in a substantial reduction in estimated mean attack frequency from 4.5 attacks every twenty-four hours to 2.6 after treatment.

Professor Peter Goadsby who is lead author of the paper commented:


Cluster headache is a dreadful, extremely painful and disabling condition that can be very complex to manage. Given the unmet need for effective and safe treatments, we were excited to see the outcomes in these patients of an approach offering very considerable promise for future development.


The treatment, which is self-administered by the patient for 120 seconds at home, involves placing the small, hand-held gammaCore device on the skin of the neck over the vagus nerve. In this study, patients carried out either two or three 120-second doses of stimulation twice per day - morning and evening - while acute attacks were treated with up to six doses at the onset of the attack. Patients reported no serious adverse events.

JP Errico, founder and CEO of electroCore, commented:


The success of this pioneering study led to our large-scale randomized PREVA trial, which was presented at the International Headache meeting (EHMTIC) in September 2014. The results of that study demonstrated nearly the same efficacy in treating and preventing cluster headaches. The full results of the PREVA trial will shortly be published.

Our many clinical trials continue to show that our hand held, vagus nerve stimulation device gammaCore is effective in helping patients prevent and treat cluster headache.

gammaCore

As I said above, GammaCore is a useful abortive and I have been using it since 2012. But it is only part of my arsenal.

I have been on Batch's D3 regimen since January with good success, up to about 2 weeks ago.

Been using O2 for years with great abortive success, but it's not portable, so has its limitations.

as I say, 2 weeks ago the Beast returned, despite the D3. I retired 2 weeks ago and it was a surprisingly busy period, both coming up to the retirement date and since. Also, I was in Florence, Italy, last week and the combination of flights and heat seems to have increased my attacks. This is where my GammaCore came in very useful. It's so portable and I have never been questioned about it in Airport Security.

So it is a valuable part of my arsenal, but it's not a magic wand.

Peter.

Thierry,
Thanks a million for the good wishes. Retirement takes 40 years to come around. I won't be wasting it. We love to travel, so lots of that is planned. Rome in a few weeks. Italy is a favourite.

I tried the 50K D3 under the tongue this morning and I'm off to the Golf course shortly, so hopefully it does the trick. Tried it before and it worked for a while, fingers crossed.

Hope you're keeping well. Sounds like you hade a nice summer in the Sun.

I'll let you know later how I got on with the Beast today.

Cheers......Peter.

Thanks Colin,

I'm calling it Phase 3.

Peter.