Gary,

Thank you for the kind words. 

Treating cluster headache (CH) patients with the vitamin D3 anti-inflammatory regimen to prevent their CH represents a paradigm shift from the conventional Standards of Care recommended treatments for CH.
   
The standards of care recommended treatments address the neurological symptoms of CH as a trigeminal autonomic cephalalgia (TAC) with neurogenic origins in the hypothalamus and manifestations in the trigeminal nerves.  Acute treatments include oxygen therapy inhalation with non-rebreathing mask at flow rates of 15 to 25 liters/minute, followed by Sumatriptan Succinate (Imitrex). 

Subcutaneous injections of Imitrex are effective in aborting CH in 5 to 10 minutes.  Imitrex nasal spray can be effective in 10 to 20 minutes.  Imitrex tablets are usually effective in 20 to 30 minutes.  Typical prophylactic treatments include a prednisone taper as a transitional preventative while titrating up with the longer-term preventative verapamil, a calcium channel blocker and in some cases, lithium. 

Greater Occipital Nerve (GON) blocks and Sphenopalatine Ganglion (SPG) blocks have also proven to effective preventative treatments for some episodic CH'ers.

The anti-inflammatory regimen with vitamin D3 is a completely different treatment modality that addresses vitamin and mineral deficiencies as an underlying cause or contributor of CH. 

That > 82% of over 600 CH’ers respond favorably to a daily regimen of vitamin D3, Omega-3 fatty acids and the vitamin D3 cofactors that support vitamin D3 pharmacokinetics and pharmacodynamics suggests CH is a genetotrophic disease. 

In 1956 Dr. Roger J. Williams, PhD., the biochemist who discovered the B-vitamin pantothenic acid, coined the term "genetotrophic disease" to describe diseases which resulted from genetically determined nutritional metabolic needs not being met by the individual and which result in poor gene expression. 

Professor Arno Motulsky, University of Washington School of Medicine, a founder of the field of pharmacogenetics, i.e. the role of genetic variation in response to drugs, has recently argued that many of the common degenerative diseases are the result of the imbalance nutritional intake with genetically determined needs for good health.

If you stop and think about it, there are a number of diseases that meet the definition of a genetotrophic disease... 

Beri Beri - caused by a lack of vitamin B1 (thiamine).

Scurvy - a disease resulting from a deficiency of vitamin C.

Rickets - a defective mineralization or calcification of bones caused by a deficiency or impaired metabolism of vitamin D.

Osteomalacia - The most common cause of osteomalacia is a deficiency of vitamin D.

So it's not a stretch to opine that cluster headache is also the result of a vitamin D3 deficiency...

Who knows... In 10 to 20 years, the medical community might just consider cluster headache a genetotrophic disease...

In the mean time, those of us who use this regimen of vitamin D3 and co-nutrients to prevent our CH, know it as a safe, healthy and cost effective alternative to some very expensive pharmaceuticals used to treat our disorder.

Take care,

V/R, Batch