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  New CH.com Forum › Cluster Headache Help and Support › Medications,  Treatments,  Therapies › Verapamil-Simvastatin interaction
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Verapamil-Simvastatin interaction (Read 1746 times)
Bill.in.MN
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Verapamil-Simvastatin interaction
Aug 14th, 2012 at 4:48pm  
Be careful out there.  Verapamil, even at low dosages, increases the toxicity of Simvastatin.  In my case, having both atherosclerosis and chronic CHs, I faced a tough choice.  Gave up Verapamil.

I can't post links so please search the 'net for more information on this.
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Bob Johnson
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Re: Verapamil-Simvastatin interaction
Reply #1 - Aug 14th, 2012 at 6:22pm  
SIMVASTATIN may interact with VERAPAMIL

Verapamil may block the breakdown of simvastatin by the liver. If this happens, blood levels of simvastatin could be increased. This could cause a serious or potentially life-threatening side effect that involves the destruction of muscle tissue and could lead to kidney failure. Avoid using these drugs together if possible, However, if it is necessary to take verapamil and simvastatin at the same time, you may be advised to watch for symptoms like unexplained muscle pain, tenderness, or weakness. Your doctor may consider adjusting the dose of simvastatin if needed or using an alternative to simvastatin for reducing cholesterol. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.

This interaction is well-documented and is considered moderate in severity.

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