Hey Rolan,
Thanks for the update... From the descriptions of all you've been going through it's easy to see you've encountered a perfect CH storm.
It's also easy to have doubts about the effectiveness of any CH preventative when the beast is jumping ugly several times a day.
Your action to start loading is good, but it should have been coupled with a trip to your PCP for a 25(OH)D lab test. In short, you can't really say the vitamin D3 regimen isn't working unless you're taking the complete regimen at 10,000 IU/day vitamin D3 with all the cofactors and you know your 25(OH)D serum concentration is around 80 ng/mL or higher with a recent lab test.
There are a number of other things you need to do. The two year period of essentially CH pain free time coming to an end may be an indication of a B vitamin Deficiency. The best course of action is to start a 3-month course of vitamin B 50 complex. A tablet a day will do just fine.
The second thing to start is Benadryl (Diphenhydramine HCL). It's likely you're experiencing an allergic reaction that results in a flood of histamine. When that happens, nearly all CH preventatives become ineffective. A week to 10 days taking 25 mg tablet every 12 hours can have a dramatic effect... Just be careful if you need to drive as Diphenhydramine will make you drowsy. If you need to drive during the day, take 50 mg Diphenhydramine after eating the evening meal.
Diphenhydramine is a first-generation antihistamine that crosses the blood brain barrier to block H1 histamine receptors throughout the brain and in particular, the hypothalamus and trigeminal ganglia where histamine triggers the release of CGRP and other cytokines that result in neurogenic inflammation and pain.
Once these histamine receptors are blocked, vitamin D3 and other CH preventatives have a much better chance of preventing CH.
Infections are just as bad as allergies when it comes to CH preventatives...Infections trigger inflammation as part of the body's immune system response and that includes seemingly minor tooth infections. When that happens, our immune systems go into hyper drive taking priority on the consumption of vitamin D3 and its metabolites leaving too little to control and prevent CH.
Finally, if you've taken an antibiotic, you need to start taking a good probiotic. The reason for this is simple once you understand that nearly all antibiotics are indiscriminate, so wipe out the friendly colonies of bacteria called the microbiota living in your GI tract along with the offending bacteria causing the infection.
The microbiota includes bacteria, fungi, and archaea are also called the microbiome. Most people get loose as a goose within a day or two after starting an anitbiotic.
Medical science is finally starting to understand the role played by the microbiome and why it is an important part of the human immune system we need to have functioning properly to keep us healthy.
Taking a good probiotic is just the first step. The microbiota also need special food to flourish and that includes fermented vegetables like fresh sauerkraut and kimche. A serving of one or the other once a week can work wonders...
If you want to get smart on the Human Microbiome Progect (HMP), check out the following link. It's a fascinating read.
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Regarding how to read this thread... You're right, it can be a daunting task, particularly so when the CH beast is jumping ugly. I suggest starting on page 1 as I try to keep the latest version of the anti-inflammatory regimen posted there. The later (most current) posts generally cover individual situations and why we need to take these supplements.
Hope this helps.
Take care and please keep us posted.
V/R, Batch
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Anti-Inflammatory Vitamin D3 Regimen and Survey (Read 247880 times)
