Bob Johnson
CH.com Alumnus
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"Only the educated are free." -Epictetus
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Kennett Square, PA (USA)
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I'm not offering these abstracts in support of any position on the effects of MSG but, rather, as an opportunity to ask you to consider the sources and scope of any evidence we post (please see PDF file). ====
J Am Acad Nurse Pract. 2006 Oct;18(10):482-6.
Reconsidering the effects of monosodium glutamate: a literature review. Freeman M.
OhioHealth, Columbus, Ohio, USA. freeman.224@osu.edu
Abstract PURPOSE: This article reviews the literature from the past 40 years of research related to monosodium glutamate (MSG) and its ability to trigger a migraine headache, induce an asthma exacerbation, or evoke a constellation of symptoms described as the "Chinese restaurant syndrome." DATA SOURCES: Literature retrieved by a search using PubMed, Medline, Lexis-Nexus, and Infotrac to review articles from the past 40 years. CONCLUSIONS: MSG has a widespread reputation for eliciting a variety of symptoms, ranging from headache to dry mouth to flushing. Since the first report of the so-called Chinese restaurant syndrome 40 years ago, clinical trials have failed to identify a consistent relationship between the consumption of MSG and the constellation of symptoms that comprise the syndrome. Furthermore, MSG has been described as a trigger for asthma and migraine headache exacerbations, but there are no consistent data to support this relationship. Although there have been reports of an MSG-sensitive subset of the population, this has not been demonstrated in placebo-controlled trials. IMPLICATIONS FOR PRACTICE: DESPITE A WIDESPREAD BELIEF THAT MSG CAN ELICIT A HEADACHE, AMONG OTHER SYMPTOMS, THERE ARE NO CONSISTENT CLINICAL DATA TO SUPPORT THIS CLAIM. FINDINGS FROM THE LITERATURE INDICATE THAT THERE IS NO CONSISTENT EVIDENCE TO SUGGEST THAT INDIVIDUALS MAY BE UNIQUELY SENSITIVE TO MSG. Nurse practitioners should therefore concentrate their efforts on advising patients of the nutritional pitfalls of some Chinese restaurant meals and to seek more consistently documented etiologies for symptoms such as headache, xerostomia, or flushing.
PMID: 16999713 ===== Clin Exp Allergy. 2009 May;39(5):640-6. Epub 2009 Apr 6.
Monosodium glutamate 'allergy': menace or myth? Williams AN, Woessner KM.
Division of Allergy, Asthma, and Immunology, Scripps Clinic, San Diego, CA 92130, USA. a.williams33@yahoo.com
Abstract Monosodium glutamate (MSG) is a salt form of a non-essential amino acid commonly used as a food additive for its unique flavour enhancing qualities. Since the first description of the 'Monosodium glutamate symptom complex', originally described in 1968 as the 'Chinese restaurant syndrome', a number of anecdotal reports and small clinical studies of variable quality have attributed a variety of symptoms to the dietary ingestion of MSG. Descriptions of MSG-induced asthma, urticaria, angio-oedema, and rhinitis have prompted some to suggest that MSG should be an aetiologic consideration in patients presenting with these conditions. This review prevents a critical review of the available literature related to the possible role of MSG in the so-called 'Chinese restaurant syndrome' and in eliciting asthmatic bronchospasm, urticaria, angio-oedema, and rhinitis. DESPITE CONCERNS RAISED BY EARLY REPORTS, DECADES OF RESEARCH HAVE FAILED TO DEMONSTRATE A CLEAR AND CONSISTENT RELATIONSHIP BETWEEN MSG INGESTION AND THE DEVELOPMENT OF THESE CONDITIONS.
PMID: 19389112
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