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New CH.com Forum › Cluster Headache Help and Support › Medications, Treatments, Therapies › Tizanidine

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Tizanidine (Read 1688 times)

LasVegas CH.com Sponsor Offline Episodic CH since 11 yrs old, now 50. Posts: 2020 north of the 60th parallel Gender:	Tizanidine Mar 26^th, 2010 at 4:43pm Anybody take this with success for CH's?
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deltadarlin CH.com Alumnus Offline I love YaBB 1G - SP1! Posts: 3823 Downsville LA Gender:	Re: Tizanidine Reply #1 - Mar 26^th, 2010 at 6:51pm I had to look that one up! Not a clusterhead myself, but I'm not seeing where it would help the actual headache itself (might work wonders for my migraines though if it didn't cause liver damage). Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to or
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monty

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The Swamp, Florida

Re: Tizanidine
Reply #2 - Mar 26^th, 2010 at 10:10pm

Haven't heard of that one - it is billed as a 'muscle relaxant' but a quick scan of the literature shows it also seems to interfere with neuropathic pain, spasms, and other things. It also interferes with excitatory amino acid like glutamate (which Namenda does) .... not really sure if it would help or not.

It has been used on trigeminal neuralgia, but its effectiveness for that is not clearly established..

« Last Edit: Mar 26^th, 2010 at 10:12pm by monty »

The outer boundary of what we currently believe is feasible is far short of what we actually must do.

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neuropath

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Same Hit, Different Day

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Re: Tizanidine
Reply #3 - Mar 27^th, 2010 at 5:15am

Not much literature on the use with CH. A VERY small clinical trial seems to have been conducted on chronic CH patients. Found an excerpt and a site where the full text is available.

"Tizanidine for Chronic Cluster Headache"
Roberto D'Alessandro, MD
Institute of Clinical Neurology Via Ugo Foscolo 7 40123 Bologna, Italy

Franco Granella, MD
Parma, Italy

Arch Neurol. 1996;53(11):1093.

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Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

"The treatment of chronic cluster headache is based on a few proven drugs, namely lithium salts, corticosteroids, methysergide maleate, and verapamil hydrochloride.1 However, some patients do not stop having attacks, despite treatment with 1 or more of these drugs. More recently, transdermal clonidine was proposed as a possible effective and safe treatment.2 This drug may act by reducing the sharp fluctuations of the sympathetic nervous system occurring during the attacks,3 by inhibiting the central sympathetic pathway. Tizanidine, an imidazoline derivative, usually used as a central muscle relaxant, is structurally similar to clonidine and seems to act through central 2-receptor agonistic activity.4 We treated 5 consecutive patients with chronic cluster headache resistant to previous treatments with tizanidine as add-on therapy. Results are summarized in the Table. In 3 patients the attacks ceased and any other treatment was discontinued, in 1 there was a marked reduction . . . [Full Text PDF of this Article]

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Bob Johnson CH.com Alumnus Offline "Only the educated are free." -Epictetus Posts: 5965 Kennett Square, PA (USA) Gender:	Re: Tizanidine Reply #4 - Mar 27^th, 2010 at 3:50pm When I see only one article and that from 1996--I call it a dead fish.
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monty CH.com Hall of Famer Offline Posts: 1056 The Swamp, Florida	Re: Tizanidine Reply #5 - Mar 29^th, 2010 at 10:55am Bob Johnson wrote on Mar 27^th, 2010 at 3:50pm: When I see only one article and that from 1996--I call it a dead fish. I dunno - I think lots of promising leads get abandoned because of funding issues. CH isn't a high research priority. I'm not saying this med is great (or worthless) for CH .... just that we don't really know.
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neuropath

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Same Hit, Different Day

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Re: Tizanidine
Reply #6 - Mar 29^th, 2010 at 11:45pm

Interesting that, though the sample is very small, as an add on therapy it seemed to help some chronic patients.

The med appears to display similar properties to Topamax and may be something that works for some who show adverse effects to Topamax as add-on or combo. Perhaps worth discussing with your doc. Tizanidine does find more regular use in Migraine prevent, it appears.

But as Bob says, why did nobody, if no the author himself, run with it in the past 15 years?

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