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New CH.com Forum › Cluster Headache Help and Support › Medications, Treatments, Therapies › Kudzu, Melatonin and rc seeds

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Kudzu, Melatonin and rc seeds (Read 2655 times)

Chad

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Kudzu, Melatonin and rc seeds
Sep 14^th, 2009 at 8:12am

I've been eating seeds for a year now as preventative maintenance and have had much success, however I have a batch that are a bit old (1 year old) so I have ordered more from Iamshaman. In the meantime i'd like to try Melatonin to help with these night hits. I've had 1 to 2 hits a night for the last 3 nights. I also have a bottle of Kudzu that i'd like to try. I'm trying to avoid the triptans so I can take a new dose of seeds when they arrive. I don't feel like detoxing for 5 days, but if i'm desperate, i'll use the trex at work.
I know a bunch of you will come on and promote the O2 and I do plan on doing that, but it will be without insurance and out of my pocket. Can somebody PM me with the best non re-breather mask and regulator to get before I get a tank. I work
at company with a fab shop, so welders O2 (M tank) is easily accessible.

Does anybody know if Melatonin or Kudzu will interfere with the way LSA works? I couldn't find any
quick answers on Clusterbusters.

Thanks,
Chad

When the PAIN starts, I FIGHT back!

Rivea Corymbosa seeds were my KO punch, now D3 is the front runner!

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Chad

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Re: Kudzu, Melatonin and rc seeds
Reply #1 - Sep 14^th, 2009 at 8:29am

Nevermind about the Melatonin or Kudzu. Just found the answer on Clusterbusters. It's referring to how it reacts with psilocybin which is a LSA cousin. For those of you who have the same question, here is what I "cut and pasted" from their site.

# *Kudzu:
"Anecdotal evidence suggests that kudzu can block the effects of psilocybin; one person reports that taking a normal dose of kudzu for a week completely blocked the psychological and physical effects of 1.5 grams of psilocybin mushrooms. Those interested in the Clusterbuster approach should consider the strong possibility that kudzu will interfere with that therapeutic approach." [Flo]
See: Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to or
# *Melatonin:
Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat AS Eison, RP Freeman, VB Guss, UL Mullins and RN Wright CNS Developmental Pharmacology, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut, USA.
Interactions between melatonin and serotonin type 2A (5-HT2A) receptors in the regulation of the sleep-wakefulness cycle in the rat have been reported. We studied the acute effects of melatonin and related agonists on 5-HT2A neurotransmission as reflected in behavioral (head shake) and biochemical [phosphoinositide (PI) hydrolysis] responses to 5-HT2A receptor stimulation. Like 5-HT1A agonists and antidepressants, acute administration of melatonin and related agonists inhibited the 5- HT2A-mediated (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane- induced head shake in a dose-dependent manner. Consistent with these behavioral findings, in vitro incubation of cortical slices with melatonin agonists robustly inhibited 5-HT2A receptor-mediated PI hydrolysis in a noncompetitive manner. 2-Iodomelatonin-induced reductions in 5-HT2A-stimulated PI hydrolysis were blocked by preincubation with the melatonin antagonist N-acetyltryptamine. Further, pretreatment of rats in vivo with melatonin and related agonists reduced the cortical PI hydrolysis response to the 5-HT2A agonist alpha methyl-5-HT but did not alter cortical 5-HT2A receptor density. The present data support an interaction between melatonin and 5-HT2A receptors in the central nervous system.
Volume 273, Issue 1, pp. 304-308, 04/01/1995
Copyright © 1995 by American Society for Pharmacology and Experimental Therapeutics

If you look at a molecular diagram of melatonin and compare it to psilocin you will notice marked similarities. I have always thought there would be some kind of interaction between the two. We don't KNOW if there is any interaction, but I'd say the odds are pretty good there may be.

« Last Edit: Sep 14^th, 2009 at 8:31am by Chad »

When the PAIN starts, I FIGHT back!

Rivea Corymbosa seeds were my KO punch, now D3 is the front runner!

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Callico

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Re: Kudzu, Melatonin and rc seeds
Reply #2 - Sep 15^th, 2009 at 10:13pm

the only help I can be is on the mask. the O2ptimask is the cat's meow for masks. You can order it from the store on the left, and it is worth every penny. Linde developed it for CH use.

I can't help on the regulator, but if you are going to be buying your own I would strongly recommend you go to at least a 25 lpm regulator.

Jerry

"Political correctness is a doctrine, fostered by a delusional, illogical minority, and rabidly promoted by an unscrupulous mainstream media, which holds forth the proposition that it is entirely possible to pick up a piece of dung by the clean end." Texas A&M Student (unknown)

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Lawrence CH.com Veteran Offline There WILL be a cure Posts: 163 Merrillville, Indiana Gender:	Re: Kudzu, Melatonin and rc seeds Reply #3 - Sep 16^th, 2009 at 6:48pm Callico wrote on Sep 15^th, 2009 at 10:13pm: the only help I can be is on the mask. the O2ptimask is the cat's meow Jerry LOL
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JustNotRight

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Re: Kudzu, Melatonin and rc seeds
Reply #4 - Sep 16^th, 2009 at 7:55pm

Callico wrote on Sep 15^th, 2009 at 10:13pm:

Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to

An eye for eye only ends up making the whole world blind.
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If you are going through hell...Just keep going

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Redd CH.com Sponsor Offline Posts: 8457 Stevens Point USA Wisconsin Gender:	Re: Kudzu, Melatonin and rc seeds Reply #5 - Sep 16^th, 2009 at 8:24pm I'll add that is is best to remain detoxed from anything and everything for 3-5 days before a seed dose just to err on the side of caution.
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