Peppermint wrote on Feb 4^th, 2009 at 9:16pm:

Hello, Peppermint. The latin site is not so different, it's really nothing that a little and an unexperienced copy of ch.com. You must know that it was created some years ago by Dania, a latin ch.com member. She tried to do some spanish language ch.com, so ch.com is the world's big father or forums.

Hello, catlind

Really I could read posts like yours for hours. I'm in your line, but if I can, I would disagree and I will thanks your view about. And for first, I sign your disclaimer ..

In general terms, our attacks consists basically in a trigeminal inflammation, and this inflammation is what produces the CGRP secretion, yes. But is more there. The CGRP activates the platelets, forcing it to free the uptaked serotonine (5HT2C receptors), and matocits to free histamine, who increases the vasodilatation and press the nerve continuing the inflammation in a feed-back process. So many ideas to explain the start of the attack: vasodilatacion carotide/leptomeningen vases, pressing trigeminal .. or .. inflammation trigeminal and CGRP after this produce the vasodilatation .. or central hipotalamic signal .... But I think it's more important to talk about the attack's end. I'm convinced that the increasing serotonine freeded by platelets finally do its work over receptors 5HTP1B and achieve constriccion enough to stop the process.

Some years ago I read from a mexican doctor who participated in the Sumatriptan developpment that they had injected serotonine IV to a CH and inmediatly stopped the attack. But the secondary effects were so strong (he don't related what were), and then, they started to look for some selectiv agonist to the 5HT!B receptors. And they developped the sumatriptan.

For me, it's no relevant the really origine of CH. It's more important, and I did it, to construct an hypothese that allows to plain metods to fight against it, and the results of this methods will show the hypoteses ("or model") validity.

Every step I did in the serotonine way, I did it suffering attacks because of trying every trick one by one. So many factors involved in serotonine transformation from L-triptophane, even in the brain level of L-T, carriers, competitors, glucose, carbohydrats, and so on.!!

I you want and you have time, I would like to discuss with you a big lot of things. I thinkmy hipotheses (true or false, no matter), can today explain so much of the CH facts, and I will appreciate your view about. Tell me please if you have time for it, otherwise, it can be at other moment in the future.

Best regards.

P.S. I know so many names are wrong writed, but if you understand them, I let it be. My dictionary spainsh-english is hot!!