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Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Can Too Much Vitamin D Be Toxic? http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1457559940 Message started by thierry on Mar 9th, 2016 at 4:45pm |
Title: Can Too Much Vitamin D Be Toxic? Post by thierry on Mar 9th, 2016 at 4:45pm
Extract from an article taken from livescience.com:
"As more Americans take vitamin D supplements, there has been concern that more people could experience toxic effects from very high vitamin D levels. But a new study shows that people rarely experience harmful side effects when taking large amounts of vitamin D. Researchers analyzed information from more than 20,000 vitamin D blood tests performed on people living in Rochester, Minnesota, and the surrounding area over a 10-year period. They looked to see how many people had "high" vitamin D levels, defined as levels over 50 nanograms per milliliter. (Normal vitamin D levels are between 20 and 50 ng/mL.) About 8 percent of the people had vitamin D levels over 50 ng/mL, but 0.6 percent had even higher levels, over 80 ng/mL, and 0.2 percent had levels over 100 ng/mL. The researchers also found that the proportion of people with high vitamin D levels increased considerably during the study period — from 9 per 100,000 people in 2002 to 233 per 100,000 people in 2011. This spike is likely due to an increase in people taking vitamin D supplements, either because a doctor prescribed them or because they decided on their own to take them, the researchers said. Despite this increase, the people in the study rarely experienced hypercalcemia, or high blood calcium levels that can occur as a result of high vitamin D levels. The condition can cause weakness, vomiting and kidney problems, and is the main side effect of high vitamin D levels. In fact, there was no link between people's vitamin D levels and their blood calcium levels. [9 Good Sources of Disease-Fighter Vitamin D] "We found that, even in those with high levels of vitamin D over 50 ng/mL, there was not an increased risk of hypercalcemia, or elevated serum calcium, with increasing levels of vitamin D," study co-author Dr. Thomas D. Thacher, a family medicine expert at Mayo Clinic, said in a statement. The study identified just four cases over the 10-year period of people who had hypercalcemia associated with high vitamin D levels, and three of those were mild cases in which people did not have symptoms. (In those three cases, the condition was revealed only by the blood test.) There was just one case of true vitamin D toxicity, in a 51-year-old woman who had vitamin D levels of 364 ng/mL. The woman had taken 50,000 international units (IU) of vitamin D per day for three months, along with calcium supplements, and went to the doctor with weight loss, vomiting and confusion." The D3 regimen recommended on this site for CH sufferers advises that we take 10000iu D3/day NOT 50000 IU /DAY FOR 3 MONTHS as in the study above |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by MDR on Mar 9th, 2016 at 5:24pm
Well I take 30,000IU and 2 fish oil and calcium supplement for over 3 yrs. and so far no problems plus I never get blood work done.
MDR. |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by thierry on Mar 9th, 2016 at 5:31pm |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by MDR on Mar 9th, 2016 at 8:04pm
Thanks Thierry,
Picking up tomorrow after reading the link thank you. Mark. |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Hoppy on Mar 9th, 2016 at 10:12pm
Thierry posted,
Researchers analyzed information from more than 20,000 vitamin D blood tests performed on people living in Rochester, Minnesota, and the surrounding area over a 10-year period. They looked to see how many people had "high" vitamin D levels, defined as levels over 50 nanograms per milliliter. (Normal vitamin D levels are between 20 and 50 ng/mL.) About 8 percent of the people had vitamin D levels over 50 ng/mL, but 0.6 percent had even higher levels, over 80 ng/mL, and 0.2 percent had levels over 100 ng/mL. The researchers also found that the proportion of people with high vitamin D levels increased considerably during the study period — from 9 per 100,000 people in 2002 to 233 per 100,000 people in 2011. This spike is likely due to an increase in people taking vitamin D supplements, either because a doctor prescribed them or because they decided on their own to take them, the researchers said. This is just a research/study! On folks vitamin D levels without taking any vitamin D supplements, and some that are because a doctor prescribed them, but no mention about the dosage they are taking. Hoppy |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by thierry on Mar 10th, 2016 at 2:26am
You're right Hoppy, though I posted the article to highlight that one would have to take a lot more Vit D3 than the amount indicated in the D3 regimen for CHers to reach toxocity levels. + the regimen indicates that we should take a good quality vit K to keep the calcium away from our circulatory system and direct it where it should go, ie: our bones.
|
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Hoppy on Mar 10th, 2016 at 3:38am
Thierry wrote, the regimen indicates that we should take a good quality vit K to keep the calcium away from our circulatory system and direct it where it should go, ie: our bones.
Yes! Since adding the K2 to the regimen my old bones are feeling a lot better. :) Hoppy |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Bob Johnson on Mar 10th, 2016 at 2:45pm Pharmacotherapy. 2012 Apr;32(4):354-82. Vitamin D supplementation: what's known, what to do, and what's needed. Haines ST, Park SK. Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA. shaines@rx.umaryland.edu Abstract The use of vitamin 0 supplements to prevent and treat a wide range of illnesses has increased substantially over the last decade. Epidemiologic evidence links vitamin D deficiency to autoimmune disease, cancer, cardiovascular disease, depression, dementia, infectious diseases, musculoskeletal decline, and more. The Institute of Medicine published an exhaustive report in 2010 that concluded that vitamin D supplementation for indications other than musculoskeletal health was not adequately supported by evidence and that most North Americans receive sufficient vitamin D from their diet and sun exposure. These conclusions are at odds with some clinical practice guidelines; thus, we sought to summarize the best available evidence regarding the benefits of vitamin D supplementation, to examine the potential risks, and to provide practical dosing advice. The adequacy of vitamin D stores is determined by measuring the 25-hydroxyvitamin D serum concentrations. THE DEMARCATIONS between deficiency (<20 ng/ml), insufficiency (20-30 ng/ml), and optimal (30-80 ng/ml) serum concentrations ARE CONTROVERSIAL. Vitamin D in doses of 800-5000 lU/day improve musculoskeletal health (e.g., reduces the rate of fractures and falls in older adults (aged = 65 yrs). In patients with documented vitamin D deficiency, a cumulative dose of at least 600,000 lU administered over several weeks appears to be necessary to replenish vitamin D stores. Single large doses of 300,000-500,000 IU should be avoided. Vitamin D supplementation should not be offered routinely to other patient populations. ALTHOUGH RESULTS FROM SOME PROSPECTIVE CLINICAL TRIALS ARE PROMISING, MOST HAVE NOT BEEN ROBUSTLY DESIGNED AND EXECUTED. THE DECISION BY YOUNG, OTHERWISE HEALTHY ADULTS TO TAKE VITAMIN D IN DOSES OF 2000 LU/DAY OR LOWER IS UNLIKELY TO CAUSE HARM. For patients who are not at risk for developing vitamin D deficiency, sensible sun exposure is an inexpensive and enjoyable way to maintain vitamin D stores. © 2012 Pharmacotherapy Publications, Inc. ==============================http://ods.hod.nih.gov/factsheets/VitaminD-HealthProfessional/ (This section found at the end of this long article.) Health Risks from Excessive Vitamin D VITAMIN D TOXICITY CAN CAUSE NON-SPECIFIC SYMPTOMS SUCH AS ANOREXIA, WEIGHT LOSS, POLYURIA, AND HEART ARRHYTHMIAS. MORE SERIOUSLY, IT CAN ALSO RAISE BLOOD LEVELS OF CALCIUM WHICH LEADS TO VASCULAR AND TISSUE CALCIFICATION, WITH SUBSEQUENT DAMAGE TO THE HEART, BLOOD VESSELS, AND KIDNEYS [1]. The use of supplements of both calcium (1,000 mg/day) and vitamin D (400 IU) by postmenopausal women was associated with a 17% increase in the risk of kidney stones over 7 years in the Women's Health Initiative [65]. A serum 25(OH)D concentration consistently >500 nmol/L (>200 ng/mL) is considered to be potentially toxic [5]. Excessive sun exposure does not result in vitamin D toxicity because the sustained heat on the skin is thought to photodegrade previtamin D3 and vitamin D3 as it is formed [6]. In addition, thermal activation of previtamin D3 in the skin gives rise to various non-vitamin D forms that limit formation of vitamin D3 itself. Some vitamin D3 is also converted to nonactive forms [1]. Intakes of vitamin D from food that are high enough to cause toxicity are very unlikely. Toxicity is much more likely to occur from high intakes of dietary supplements containing vitamin D. Long-term intakes above the UL increase the risk of adverse health effects [1] (Table 4). Most reports suggest a toxicity threshold for vitamin D of 10,000 to 40,000 IU/day and serum 25(OH)D levels of 500–600 nmol/L (200–240 ng/mL). While symptoms of toxicity are unlikely at daily intakes below 10,000 IU/day, the FNB pointed to emerging science from national survey data, observational studies, and clinical trials suggesting that even lower vitamin D intakes and serum 25(OH)D levels might have adverse health effects over time. THE FNB CONCLUDED THAT SERUM 25(OH)D LEVELS ABOVE APPROXIMATELY 125–150 NMOL/L (50–60 NG/ML) SHOULD BE AVOIDED, AS EVEN LOWER SERUM LEVELS (APPROXIMATELY 75–120 NMOL/L OR 30–48 NG/ML) ARE ASSOCIATED WITH INCREASES IN ALL-CAUSE MORTALITY, GREATER RISK OF CANCER AT SOME SITES LIKE THE PANCREAS, GREATER RISK OF CARDIOVASCULAR EVENTS, AND MORE FALLS AND FRACTURES AMONG THE ELDERLY. The FNB committee cited research which found that vitamin D intakes of 5,000 IU/day achieved serum 25(OH)D concentrations between 100–150 nmol/L (40–60 ng/mL), but no greater. Applying an uncertainty factor of 20% to this intake value gave a UL of 4,000 IU which the FNB applied to children aged 9 and older, with corresponding lower amounts for younger children. Table 4: Tolerable Upper Intake Levels (ULs) for Vitamin D [1] Age Male Female Pregnancy Lactation {see at citation source} |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Hoppy on Mar 10th, 2016 at 5:00pm
Long-term intakes above the UL increase the risk of adverse health effects [1] (Table 4). Most reports suggest a toxicity threshold for vitamin D of 10,000 to 40,000 IU/day and serum 25(OH)D levels of 500–600 nmol/L (200–240 ng/mL). While symptoms of toxicity are unlikely at daily intakes below 10,000 IU/day, the FNB pointed to emerging science from national survey data, observational studies, and clinical trials suggesting that even lower vitamin D intakes and serum 25(OH)D levels might have adverse health effects over time. THE FNB CONCLUDED THAT SERUM 25(OH)D LEVELS ABOVE APPROXIMATELY 125–150 NMOL/L (50–60 NG/ML) SHOULD BE AVOIDED, AS EVEN LOWER SERUM LEVELS (APPROXIMATELY 75–120 NMOL/L OR 30–48 NG/ML) ARE ASSOCIATED WITH INCREASES IN ALL-CAUSE MORTALITY, GREATER RISK OF CANCER AT SOME SITES LIKE THE PANCREAS, GREATER RISK OF CARDIOVASCULAR EVENTS, AND MORE FALLS AND FRACTURES AMONG THE ELDERLY. The FNB committee cited research which found that vitamin D intakes of 5,000 IU/day achieved serum 25(OH)D concentrations between 100–150 nmol/L (40–60 ng/mL), but no greater. Applying an uncertainty factor of 20% to this intake value gave a UL of 4,000 IU which the FNB applied to children aged 9 and older, with corresponding lower amounts for younger children.
I've taken 5000iu/day of vitamin D together with the other co-factors for the vitamin D regimen over the past 3yrs and my levels are (100–150 nmol/L (40–60 ng/mL) as stated above, and has kept me CH free! After doing battle with the beast for 43yrs. Cheers Hoppy |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Hoppy on Mar 11th, 2016 at 5:51pm
Swisse have just brought out vitamin K2 (menaquinone 7) 45mcg + D3 1000iu. So, I take 5000iu vitamin D/day and 200mcg K2/day, as suggested in the vitamin D regimen, which fits perfectly with a 20% loss of vitamin D when absorbed (4000iu), but what about those taking 10000iu vitamin D/day, wouldn't they need to take 400mcg/day of K2 to keep the calcium away from their circulatory system. Thoughts.
Cheers Hoppy |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by thierry on Mar 12th, 2016 at 1:16am
Hi Batch,
Thank you for making VERY clear that taking the amounts of D3 in the regimen are VERY VERY far from being toxic. Not only that, but your clear and precise explanation indicates that a D3 regimen can be used to treat not only our dreaded CH, but is also used by doctors for safely treating a range of other ailments. It is also reassuring to know that taking super K as part of the regimen keeps the calcium from depositing in our veins/arteries or our kidneys or any other organ but instead goes to our bones where it s useful. All the best Batch |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Peter510 on Mar 12th, 2016 at 6:40am
Hello to all,
I become more and more convinced that D3 in the quantities Batch recommends is beneficial for a number of ailments and this comes from personal experience. My CH turned chronic a little over 3 years ago after years of being episodic. I struggled to work and even live a normal life, for 2 years until I started the D3 Regimen early last year. I cannot describe the improvement it has made, although I'm not 100% PF, I do get 90% success. I HAVE TAKEN NO OTHER MEDS IN THAT TIME. My wife had knee surgery in March '15 and I started her on D3 at that time, with advice from Batch. Her health has not been great for a few years with repeated surgery and severe Anaemia, so the expectation for her speed of recovery following surgery was, understandably, not high. The Orthopaedic Surgeon was amazed at how quickly she healed and was back walking. SHE TOOK NO MEDS DURING THAT TIME. Last year my Brother was diagnosed with cancer of the liver and subsequently had half his liver removed with the tumour. Again, I started him on D3, with advice from Batch and again, his Oncologist is delighted with his progress and his cancer markers during his subsequent Chemotherapy sessions are way down. Other than pain killers and the obvious Chemo he has been taking NO OTHER MEDS DURING THAT TIME. Back to me. Last July I was diagnosed with COPD (Emphysema and Pulmonary Fibrosis), which, I was told was at an early stage and I should get 10/12 more years in the game. I was told that both conditions are progressive without a cure at present, but the Consultant hoped to keep me off Steriods for another year or so. My lung function was measured at 68% at that time. So, I gave up cigs and upped my D3 to 20,000 iu/day for a few months. Went for my lung function test again last week and the Consultant could not believe the result. Measuring at 83% my score is back within the normal range for my age group. He did rant a bit about how he has not seen this before and he is off to to research the D3 in detail for other patients and he does not want to see me again until next year. NO OTHER MEDS TAKEN IN THAT TIME. OK, so that's all a bit long winded and I'm sorry for that, but it's the only way to tell the story. It may not be for everyone and you have to make your own minds up on the benefits of D3. I'm convinced. Best to all, Peter. |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Batch on Mar 12th, 2016 at 2:50pm
Peter,
Thank you for the thoughtful post. I'm curious how many other members of this forum taking the anti-inflammatory regimen to prevent their CH have similar stories about the health benefits of vitamin D3 beyond preventing CH... Take care and thanks again, V/R, Batch |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Stevo on Mar 13th, 2016 at 8:53am
Hey Peter,
Great news about your Lung score, and well done for keeping off the cigs |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Peter510 on Mar 13th, 2016 at 9:15am
Hey Steve,
Thanks. How are you getting on ? Are you PF on the D3 ? Are you still with the same Nero ? Best regards, Peter. |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Stevo on Mar 14th, 2016 at 7:59am
Hi Peter,
I'm doing great on the D3 - sailed through winter with just a few shadows now and again. Night and day from last year. I 'off-hired' the neuro last summer after speaking with you and another 150Eur session thrown down the pan. As an aside to the theme of D3 additional benefits, I was commenting only recently the lack of cold and flu I have suffered in the last 12 months whilst on the D3; I normally suffer 2-3 colds during winter but this year not a sniffle! All the best Steve |
Title: Re: Can Too Much Vitamin D Be Toxic? Post by Peter510 on Mar 14th, 2016 at 2:17pm
Steve,
Good news on the CH's, the cold & flu and the Neuro. It's great to hear news like that. Keep the faith, Peter |
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