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Cluster Headache Help and Support >> Medications,  Treatments,  Therapies >> Re: ATI Stimulation Clinical Trial for Chronic Cluster
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Message started by Hoppy on Aug 11th, 2015 at 4:01pm

Title: Re: ATI Stimulation Clinical Trial for Chronic Cluster
Post by Hoppy on Aug 11th, 2015 at 4:01pm
Hi David and welcome,
I'm not versed with this particular procedure, but ganglion blocks work for some and not others, again we are all different. You mentioned your on 320mg of verapamil a day, that dosage is a little low when it comes to treating CH's, 480mg a day seems to work the best for most folk, although some folk go as high as 1000mg a day before they get any relief.

Hoppy

Title: Re: ATI Stimulation Clinical Trial for Chronic Cluster
Post by Bob Johnson on Aug 12th, 2015 at 11:09am
David, by definition, a clinical trial means that there is not a pool of out come data to answer you question. So, your expectation must be one of trying without a preformed expectaion of the results.

When you have your screening visit, be sure you understand the guildlines about using/not using other meds/treatments at the same time.

We'll be interested in our results....

Title: Re: ATI Stimulation Clinical Trial for Chronic Cluster
Post by Bob Johnson on Aug 13th, 2015 at 12:41pm
Once you complete the trial, tuck this informationn into your files as a consideration.

After taking the first dose, this became my only med needed. Cost is low, easy to carry (pill), action fast, and, as you will read, totally stopped Clusters for few folks.
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Headache 2001 Sep;41(8):813-6 

Olanzapine as an Abortive Agent for Cluster Headache.


Rozen TD.
Department of Neurology, Jefferson Headache Center/Thomas Jefferson University Hospital, Philadelphia, Pa.

OBJECTIVE: To evaluate olanzapine as a cluster headache abortive agent in an open-label trial. BACKGROUND: Cluster headache is the most painful headache syndrome known. There are very few recognized abortive therapies for cluster headache and fewer for patients who have contraindications to vasoconstrictive drugs. METHODS: Olanzapine was given as an abortive agent to five patients with cluster headache in an open-label trial. THE INITIAL OLANZAPINE DOSE WAS 5 MG, AND THE DOSE WAS INCREASED TO 10 MG IF THERE WAS NO PAIN RELIEF. THE DOSAGE WAS DECREASED TO 2.5 MG IF THE 5-MG DOSE WAS EFFECTIVE BUT CAUSED ADVERSE EFFECTS. To be included in the study, each patient had to treat at least two attacks with either an effective dose or the highest tolerated dose. RESULTS: Five patients completed the investigation (four men, one woman; four with chronic cluster, one with episodic cluster). Olanzapine reduced cluster pain by at least 80% in four of five patients, and TWO PATIENTS BECAME HEADACHE-FREE AFTER TAKING THE DRUG. Olanzapine typically alleviated pain within 20 minutes after oral dosing and treatment response was consistent across multiple treated attacks. The only adverse event was sleepiness. CONCLUSIONS: Olanzapine appears to be a good abortive agent for cluster headache. IT ALLEVIATES PAIN QUICKLY AND HAS A CONSISTENT RESPONSE ACROSS MULTIPLE TREATED ATTACKS. IT APPEARS TO WORK IN BOTH EPISODIC AND CHRONIC CLUSTER HEADACHE.

PMID 11576207 PubMed

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Olanzapine has a brand name of "Zyprexa" and is a antipsychotic. Don't be put off by this primary usage. Several of the drugs used to treat CH are cross over applications, that is, drugs approved by the FDA for one purpose which are found to be effective with unrelated conditions--BJ.
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Title: Re: ATI Stimulation Clinical Trial for Chronic Cluster
Post by dauber on Aug 13th, 2015 at 1:59pm
Bob Johnson will you buy  him a  Philly steak and cheese if he asked his doctor for zyprexa?

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