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Cluster Headache Help and Support >> Medications,  Treatments,  Therapies >> Verapamil-Simvastatin interaction
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Message started by Bill.in.MN on Aug 14th, 2012 at 4:48pm

Title: Verapamil-Simvastatin interaction
Post by Bill.in.MN on Aug 14th, 2012 at 4:48pm
Be careful out there.  Verapamil, even at low dosages, increases the toxicity of Simvastatin.  In my case, having both atherosclerosis and chronic CHs, I faced a tough choice.  Gave up Verapamil.

I can't post links so please search the 'net for more information on this.


Title: Re: Verapamil-Simvastatin interaction
Post by Bob Johnson on Aug 14th, 2012 at 6:22pm
SIMVASTATIN may interact with VERAPAMIL

Verapamil may block the breakdown of simvastatin by the liver. If this happens, blood levels of simvastatin could be increased. This could cause a serious or potentially life-threatening side effect that involves the destruction of muscle tissue and could lead to kidney failure. Avoid using these drugs together if possible, However, if it is necessary to take verapamil and simvastatin at the same time, you may be advised to watch for symptoms like unexplained muscle pain, tenderness, or weakness. Your doctor may consider adjusting the dose of simvastatin if needed or using an alternative to simvastatin for reducing cholesterol. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.

This interaction is well-documented and is considered moderate in severity.

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