Post by Chad on Sep 14th, 2009 at 8:29am
Nevermind about the Melatonin or Kudzu. Just found the answer on Clusterbusters. It's referring to how it reacts with psilocybin which is a LSA cousin. For those of you who have the same question, here is what I "cut and pasted" from their site.
# *Kudzu:
"Anecdotal evidence suggests that kudzu can block the effects of psilocybin; one person reports that taking a normal dose of kudzu for a week completely blocked the psychological and physical effects of 1.5 grams of psilocybin mushrooms. Those interested in the Clusterbuster approach should consider the strong possibility that kudzu will interfere with that therapeutic approach." [Flo]
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END PRINTPAGE
# *Melatonin:
Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat AS Eison, RP Freeman, VB Guss, UL Mullins and RN Wright CNS Developmental Pharmacology, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut, USA.
Interactions between melatonin and serotonin type 2A (5-HT2A) receptors in the regulation of the sleep-wakefulness cycle in the rat have been reported. We studied the acute effects of melatonin and related agonists on 5-HT2A neurotransmission as reflected in behavioral (head shake) and biochemical [phosphoinositide (PI) hydrolysis] responses to 5-HT2A receptor stimulation. Like 5-HT1A agonists and antidepressants, acute administration of melatonin and related agonists inhibited the 5- HT2A-mediated (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane- induced head shake in a dose-dependent manner. Consistent with these behavioral findings, in vitro incubation of cortical slices with melatonin agonists robustly inhibited 5-HT2A receptor-mediated PI hydrolysis in a noncompetitive manner. 2-Iodomelatonin-induced reductions in 5-HT2A-stimulated PI hydrolysis were blocked by preincubation with the melatonin antagonist N-acetyltryptamine. Further, pretreatment of rats in vivo with melatonin and related agonists reduced the cortical PI hydrolysis response to the 5-HT2A agonist alpha methyl-5-HT but did not alter cortical 5-HT2A receptor density. The present data support an interaction between melatonin and 5-HT2A receptors in the central nervous system.
Volume 273, Issue 1, pp. 304-308, 04/01/1995
Copyright © 1995 by American Society for Pharmacology and Experimental Therapeutics
If you look at a molecular diagram of melatonin and compare it to psilocin you will notice marked similarities. I have always thought there would be some kind of interaction between the two. We don't KNOW if there is any interaction, but I'd say the odds are pretty good there may be.
# *Kudzu:
"Anecdotal evidence suggests that kudzu can block the effects of psilocybin; one person reports that taking a normal dose of kudzu for a week completely blocked the psychological and physical effects of 1.5 grams of psilocybin mushrooms. Those interested in the Clusterbuster approach should consider the strong possibility that kudzu will interfere with that therapeutic approach." [Flo]
See: START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!! You need to
or END PRINTPAGE# *Melatonin:
Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat AS Eison, RP Freeman, VB Guss, UL Mullins and RN Wright CNS Developmental Pharmacology, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut, USA.
Interactions between melatonin and serotonin type 2A (5-HT2A) receptors in the regulation of the sleep-wakefulness cycle in the rat have been reported. We studied the acute effects of melatonin and related agonists on 5-HT2A neurotransmission as reflected in behavioral (head shake) and biochemical [phosphoinositide (PI) hydrolysis] responses to 5-HT2A receptor stimulation. Like 5-HT1A agonists and antidepressants, acute administration of melatonin and related agonists inhibited the 5- HT2A-mediated (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane- induced head shake in a dose-dependent manner. Consistent with these behavioral findings, in vitro incubation of cortical slices with melatonin agonists robustly inhibited 5-HT2A receptor-mediated PI hydrolysis in a noncompetitive manner. 2-Iodomelatonin-induced reductions in 5-HT2A-stimulated PI hydrolysis were blocked by preincubation with the melatonin antagonist N-acetyltryptamine. Further, pretreatment of rats in vivo with melatonin and related agonists reduced the cortical PI hydrolysis response to the 5-HT2A agonist alpha methyl-5-HT but did not alter cortical 5-HT2A receptor density. The present data support an interaction between melatonin and 5-HT2A receptors in the central nervous system.
Volume 273, Issue 1, pp. 304-308, 04/01/1995
Copyright © 1995 by American Society for Pharmacology and Experimental Therapeutics
If you look at a molecular diagram of melatonin and compare it to psilocin you will notice marked similarities. I have always thought there would be some kind of interaction between the two. We don't KNOW if there is any interaction, but I'd say the odds are pretty good there may be.