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Cluster Headache Help and Support >> Medications,  Treatments,  Therapies >> Toxic response potential: Verapamil & grapefruit
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Message started by Bob_Johnson on Jul 15th, 2009 at 8:36am

Title: Toxic response potential: Verapamil & grapefruit
Post by Bob_Johnson on Jul 15th, 2009 at 8:36am
Because of the high doses of Verapamil used by many CH people, this warning would be wise to consider....

"The US public consumes grapefruit juice in large quantities, with 14% of the population drinking the juice at least weekly. Grapefruit juice is a well-documented inhibitor of the CYP3A4 isoenzyme, which is involved in the metabolism of over 50% of commonly prescribed drugs. Here we report an unusual case of verapamil toxicity in a 42-year-old female, which resulted from accidental ingestion of only three tablets of the sustained release preparation (120 mg each) over 24 hours which resulted in severe toxicity."

[Medscape Neurology, 7/15/09]



Title: Re: Toxic response potential: Verapamil & grapefruit
Post by Marc on Jul 15th, 2009 at 9:08am
Good reminder, Bob.

Awhile back this was discussed quite frequently around here, but I haven't seen it brought up as much lately.  

The impact of grapefruit mixed with certain medications can be very, very potent for some people.

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