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Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Ketamine coma for chronic pain? http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1246113900 Message started by MattyAA on Jun 27th, 2009 at 10:45am |
Title: Ketamine coma for chronic pain? Post by MattyAA on Jun 27th, 2009 at 10:45am |
Title: Re: Ketamine coma for chronic pain? Post by Bob_Johnson on Jun 27th, 2009 at 1:22pm |
Title: Re: Ketamine coma for chronic pain? Post by MattyAA on Jun 27th, 2009 at 1:44pm
Aye, true, neither have I tried much but I just red recently a lot on all possible pain alterations, I also pondered phanton pain, to the centre where I am going for acupuncture since I tried giving it a go, even if it fails I am meeting with pretty elder male who lost his leg and feels the pain in the lost leg not having it, It got me intrigued that maybe the brain records pain... and how they treat such pains? Bions for stimuling nerves is one option, DBS is another, ergotamines and hallucinogens is yet another, bio feed backs is one more, Ketamine belongs to hallucinogen therapies I believe?
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Title: Re: Ketamine coma for chronic pain? Post by monty on Jun 27th, 2009 at 6:10pm MattyAA wrote on Jun 27th, 2009 at 1:44pm:
Not necessarily. Ketamine blocks glutamate/NMDA receptors at lower doses, and at higher doses, it also affects the mu and sigma opiate receptors (perhaps like salvia divinorum). At large doses, it will knock a person out and cause hallucinations, but at smaller doses, it blocks pain without any hallucinations. The study that cluster quoted was interesting - but the interruption of the headaches (average 3.4 days) is too short to make that particular therapy likely to catch on ... IVs are involved procedures and ketamine has potential for abuse/dependency. If a larger dose of ketamine did 'reset' the system like clusterbusters, it might be something that catches on ... but my feeling is that twice a week IVs won't get traction in the system. There are other glutamate blockers to consider ... one person on this forum did mention their doctor putting them on a medicine used for alzheimers (memantine) that is a glutamate blocker - that didn't do much good, but might work in other patients, and there are other glutamate blockers worth trying. Magnesium is one simple, cheap and rather safe way to reduce glutamate transmission of pain, and most clusterheads have a pronounced magnesium deficiency. It may not be enough to shut the cycles off, but it can reduce pain and is a good thing to include in the arsenal. Taurine is another compound that blocks some glutamate activity without interfering with normal cognitive functions. |
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