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        New Message Board Archives >> Medications, Treatments, Therapies 2005 >> Eletriptan (Relpax) and Zoloft
        
(Message started by: headbanger45 on Jul 27^th, 2005, 1:58pm)

Title: Eletriptan (Relpax) and Zoloft
Post by headbanger45 on Jul 27^th, 2005, 1:58pm

Is there any danger taking Eletriptan (Relpax) and Zoloft on the same day? I haven't felt anything, but I've been peaking pretty good for the last few nights and wondered if I need to quit the zoloft during these harder fights with the beast.

Thanks for the heads up -

Has anyone seen my left eye, lost it last night !!!

Title: Re: Eletriptan (Relpax) and Zoloft
Post by bnfreeman on Jul 27^th, 2005, 2:03pm

I haven't taken Zoloft with Relpax, but I have been on Lexapro and Effexor and took it with no problems. I think Zoloft, Effexor and Lexapro are along the same lines. Hope this helps.

BF

Title: Re: Eletriptan (Relpax) and Zoloft
Post by E-Double on Jul 27^th, 2005, 2:10pm

From Drugs.com

sertraline and eletriptan (major Drug-Drug)

Description:
MONITOR CLOSELY: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, lithium, St. John's wort, phenylpiperidine opioids, dextromethorphan, and 5-hydroxytryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors.
MANAGEMENT:
In general, the concomitant use of multiple serotonergic agents should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia. Particular caution is advised when increasing the dosages of these agents.

Please note: only generic drug names are displayed.

sertraline (moderate Drug-Food)
Description:

MONITOR:
Grapefruit juice may increase the plasma concentrations of some orally administered drugs that are substrates of the CYP450 3A4 isoenzyme. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.

MANAGEMENT:
Patients who regularly consume grapefruits and grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that are metabolized by CYP450 3A4. Grapefruits and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.