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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by BikerBob on Jun 17th, 2005, 10:36pm Hi Joe, Here's something to watch during your trip......... http://www.maps.org/avarchive/igwana/Entheogen.mov Blessings, BB |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Candycane on Jun 18th, 2005, 6:52am Having a hellish week, for first time for awhile now I am wishing I was back on my preventives. I am chromic and 02 doesn't work well for me. Had one of those if I had a gun nites this week, LOL Anyway I am outa seeds and yesterday ordered some more but not those, wish I had, maybe today I will order some more and order a RUSH :) please keep us informed how its working. Running out my trex injections, thinking about Zomig? Don't know alot about it I will read. I know info is here just my eyes have been working for shit this week. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by nani on Jun 18th, 2005, 10:39am Candy, I may be wrong, but wouldn't using trex (or any triptan )affect the way the seeds work? Is it possible that it's not working well right now because of trex? I'm sure someone who knows will be along ... I'm just wondering. Hang in there, hun. You are stronger than it is. hugs, nani |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Chillrmn1 on Jun 18th, 2005, 10:57am Hi Nani, Good point, based on what's been brought up previously, I think have to agree with you, I am no expert. I believe 1 is an agonist and 1 is an antagonist. Not sure though, waiting to see a more expert response to this. EDIT - Or does the trex block the LSA from the receptors until detoxed? Bob |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Langa on Jun 18th, 2005, 11:15am Quote:
Good question. I thought this was the reason we were asked to detox from the get to? CC, were you detoxed from the trex and how long before you dosed the first time? Langa |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Candycane on Jun 18th, 2005, 12:04pm Yes, I was TOTALLY detoxed from everything for about 3 or more weeks now????? And was doing good but I think I screwed up not doing maintenance doses and by then I was rockin with them (sorta speak) Guess I am fucked now for awhile til they back off and I get my new seeds :( |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jun 18th, 2005, 1:16pm on 06/18/05 at 12:04:59, Candycane wrote:
Just to clarify... Are you running out of trex because you "were" running out before you stopped using it or because you have resumed using it now that the attacks have again picked up? Bobw |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Candycane on Jun 18th, 2005, 1:33pm Okay....Whole story about 3 weeks ago I started on the seeds was detoxed. They worked like a charm for 3 weeks,which is really good for me. Did not dose at all or do anything in that 3 weeks. Then finally started getting hit soooo did some more seeds ( didn't work) by then I was getting BLASTED so YES I am a wimp I have done alot of trex this week. I wish my obligations could just stop when I am that bad and in my car driving children but it doesn't so what can I say. I am not giving up I think I just messed up. I am mad at myself and thats the whole story and I am sticking to it. Waiting for my next moive Bob ;;D |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by cazman on Jun 19th, 2005, 4:14pm thats great jokrs2 i happy for you i hope it continuse to work for you im gonne do the morning glory gig again tomarrow was gonna today but its not gonna happen to many family members around to deal with keep us updated on how things go |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Candycane on Jun 20th, 2005, 4:44pm on 06/19/05 at 16:21:50, jokrs2 wrote:
Glad you had a good Fathers Day....thanks for your help this weekend with my melt down..I think my cycle has broke. Putting on my bikini now too! YIPEE!!!! :) |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 20th, 2005, 5:17pm On the issue of Trex. It has a 1/2 life elimination rate of 2 hours. Therefore: t+2 hrs = 1/2 dose t+4 hrs = 1/4 dose t+6 hrs = 1/8 dose t+8 hrs = 1/16 dose t+10 hrs = 1/32 dose t+12 hrs = 1/64 dose You could pretty much say that trex is out of your system in 12-14 hours. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jun 20th, 2005, 5:51pm on 06/20/05 at 17:17:46, Bob P wrote:
And your point is? Or is this just for informational purposes? Are you saying you have some proof that after it leaves the system, it leaves no longer lasting effects in its wake? If so, I'd be happy to add it to our database of information. You could say we're pretty much out of Afghanistan. :( Bobw |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 20th, 2005, 6:09pm LOL Should have known. You can add the above post of mine to your database. It's fact. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Jonny on Jun 20th, 2005, 6:12pm on 06/20/05 at 18:09:43, Bob P wrote:
Smarty Pants ;;D |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Ueli on Jun 20th, 2005, 6:23pm on 06/20/05 at 17:17:46, Bob P wrote:
Could be, but I'm not entirely sure about that. Your calculation holds for the Imitrex circulating in the blood stream, but we are interested in the Imitrex bound to the 5HT receptors. Only if the binding time to the receptors is short (minutes or less) we will have a dynamic equilibrium and the amount docked to the receptors is proportional to the serum concentration. I think this needs some further investigations. Ueli [smiley=smokin.gif] |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 20th, 2005, 6:23pm Well crud. Using his logic, how do we know that farting into the wind on Tuesday doesn't negate the effects of all psycadhelics for 93 1/2 hours? Ya put the numbers in front of them and they still can't accept it. Ueli - if it remained bound to the 5HT receptors we wouldn't get hit again 4 hours after shooting up. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by rextangle on Jun 20th, 2005, 6:53pm Hey BobP, It's spelled PSYCHEDELIC!!! Not "psycadhelics"... if you're gonna try to be a smart ass, learn to spell first!!!!! ;;D -From a foreigner... or do you spell it FURIGNER??? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 20th, 2005, 7:13pm Hey Rex, Personally I don't a rat's ass how it's spelled. Glad the melatonin is working for you. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jun 20th, 2005, 8:32pm on 06/20/05 at 18:09:43, Bob P wrote:
Some is and some of it is your theory. I should have known you wouldn't answer any of my questions, you never do. Half-life pertains to both/either elimination or matabolization. If you know how long all the different matabolites of the various triptans remain active, you still need to know how long the effects are for up and down regulation of the receptors. How does Imitrex increase cluster activity and length of cycles, according to your half-life theory? Or are the current theories based upon clinical trials by researchers on this subject, incorrect and you are right? Maybe you should contact them and set them straight. Feel free to explain how psilocybin stops clusters past your half life theory. Maybe you still don't believe it does. Bobw |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 21st, 2005, 9:42am It's not "my theory". It's in all the medical literature. Quote:
Terminal half life 115 minutes. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Flash on Jun 21st, 2005, 10:44am If I pour boiling water on my hand the half life of the water being at boiling point is about 0.5secs. The water then quickly cools over a period of a few seconds down to room temp and within a few minutes all traces of the water have disappeared from my hand. The burn lingers around for much longer. The same thing would be true of concentrated acid (I mean hydrocholic etc as opposed to LSD :) ) If I take a largish quantity of aspirin then the lining of my stomach becomes damaged, and this damage extends beyond the time the aspirin is in my system. If I drink alcohol then my liver ensymes remain elevate beyond the time it takes for the alcohol to leave my system. It's naive to think of something as just passing through the body. Only very inert materials go in one hole and one the other LOL. Most everything else is metabolised in some way thus becoming something else. The effects of a substance can extend beyond the time it takes to become fully metabolised. By effects I would include the time it takes for the physiological system to return to it's baseline. This is a good example of why certain people shouldn't read scientific papers then start spouting a load of bullshit based on their personal interpretation of those scientific findings. Also note that findings are not necessarily facts. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jun 21st, 2005, 10:52am on 06/21/05 at 09:42:46, Bob P wrote:
I wasn't speaking about half life values being your theory. But nice try. Still haven't answered any of my questions. Bobw |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 21st, 2005, 11:11am Quote:
The whole point is candy was using trex. People (Nani, Langa) were asking about the trex interfering with the seeds. I shared the half life of trex to show that it is out of your system in a fairly short time. Probably why they say don't mix triptans within a 24 hour period and not within a 5 day period. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jun 21st, 2005, 1:11pm on 06/21/05 at 11:11:46, Bob P wrote:
It could also be a concern more about plasma levels and the adverse effects it could have on the heart, but then what would I know. I'd know more if you'd answer my questions. It's obvious (if you look at the publications and listen to the people here that use it) that Imitrex changes the cluster intensities and frequencies, long after this 24 hour period. More to the extent of the length of the remaining cyle duration. And, it's not a change for the better. How many people here have reported an adverse long term effect vs. a positive long term effect, attributable to Imitrex use? You can believe this or not, your choice, but almost everyone that stops using Imitrex to begin getting ready for a psilocybin dose, reports the clusters begin getting better over this 5 day period, not just over the first 24 hours. There is more to it than half lives. Bobw "People are very open-minded about new things--as long as they're exactly like the old ones." Charles Kettering |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 21st, 2005, 1:48pm In this case it seems that Candycanes attacks were getting worse without trex which caused her to go to the trex. My attacks get more frequent when I use trex but return to normal pattern by the next day when I stop using it. Again, the only point was to let CC know that she is "detoxed" from trex within 24 hrs. according to those who have actually done some research and are not just throwing out guesses. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jun 21st, 2005, 3:39pm on 06/21/05 at 13:48:42, Bob P wrote:
Well, you'll have to explain this so I understand fully, but am I right in guessing that this means that if you use trex, you get more attacks within that 24 hour period you used it, than you would have had you not taken trex? If so, I'd probably ask you why on earth you'd take it at all. on 06/21/05 at 13:48:42, Bob P wrote:
I have not disagreed with anything the researchers have said about the half life of Imitrex. I have not disagreed with them and replaced their findings with my guess. I'm saying it's more complicated than a few numbers you've posted. I have no argument with the numbers. I have no reason not to believe the numbers. You're correct, the half lives are what the half lives are. I appreciate your posting the half life information. Your point to CC could have been interpruted as being, "The trex is gone within 24 hours so feel free to dose with the seeds anytime thereafter." You know it, I know it. I'm sorry but I won't let that stand uncontested when we have anecdotal evidence that points differently. You may not care how long it takes her to break the cycle but I do. I believe (correct me if I'm wrong) you feel people can try the treatment while staying on trex and other meds, get the same results and go through less pain in the process. I believe your intentions for the most part are honorable. However, I felt your post, if taken at face value, could make it more difficult for CC and others to break the cycle. My opinion vs. your opinion. I've tried to qualify what I base my opinion on. Maybe you don't accept that, fine. Maybe I'm wrong but I'm going to continue posting what I feel will give people the best shot at being pain free in the shortest amount of time. You want to consider my opinion a guess, fine. Catagorize it any way you'd like. Maybe this is a little more complicated than you can follow. Either that or you're just playing games which is ok with me as long as it provides me with an opportunity to post facts and valid discussion points. We aren't going to get anywhere if all we rely upon is what is already known. You want to wait for someone with a medical degree to tell you something new, fine. You want to wait for Goadsby to find something to break a cycle, fine. I don't want to wait. Maybe he'll find something better, first....that would be very cool. I'd like nothing better. But I won't sit around waiting in case he doesn't. While you're googling, look up the half life of alcohol and then tell me about the metabolites and damage it leaves behind, long after it's terminal half-life. Just because you haven't had a drink in a few days, doesn't mean that your hands aren't shaking. You still haven't answered any of my questions and it saddens me. [smiley=huh.gif] Have a good day Bobp and thanks for the opportunity. ;;D Bobw |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 21st, 2005, 3:47pm Quote:
I'll use cafergot. I'll push for zyprexa if I ever get another cluster. I'll hope they market the CGRP antagonists soon. I'll hope there is advancement on the alternate stuff also. I hope there are a lot of better alternatives if I ever have another cycle. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by rextangle on Jun 21st, 2005, 5:00pm BobP, How come you never answer any questions? Oh wait.... that's a question too! [smiley=huh.gif] Never Mind! |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 21st, 2005, 5:33pm Rex, How come you never have an original post? Seems you always latching on to what someone else has said to me. You remind me of that little dog in the cartoons. Used to jump around a big dog that was it's idol saying, what do we do next George. what do we do next? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by rextangle on Jun 21st, 2005, 5:41pm I have an original post actually from yesterday... did you miss it? I should have put "LSA works for me" in the title so you could jump on it and go crazy.... Oh, by the way, I clicked on your picture for the first time today, and I was shocked by what I saw... http://www.rextangle.com/pics/BobP.jpg |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 21st, 2005, 5:49pm It shouldn't suprise you, unless you just haven't been paying attention. I support the alternate treatments. You'll find my name at the Erowid site on e-mails to doctors asking about the treatment. Flash has conveniently forgotten that I helped with the first Erowid survey. I've grown my own and used them many times. I have never jumped on any post from someone who says it worked for them. I question posts that make claims but don't offer any facts to back them up. Glad to see you admire me enough to search out my picture (52 years old in that picture and just hiked to the highest point in the continental USA). |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by rextangle on Jun 21st, 2005, 6:17pm Oh, I'm not surprised at all... I'm truly sorry that none of the "alternative" treatment has worked for you. Have you ever considered HBWR seeds (I'm not putting a question mark at the end of my question just in case...) Be well, Rex |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Flash on Jun 21st, 2005, 8:45pm on 06/21/05 at 17:49:15, Bob P wrote:
No Flash hasn't. Your mind reading ability is somewhat lacking. Go back and dig out my appocaleptic flame war with OUCH (UK) from 18 months ago and you'll find that little snippet buried in there somewhere. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by nani on Jun 22nd, 2005, 12:18am So, more simply stated, candy should detox trom trex for longer than 24 hours. Is that correct? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jun 22nd, 2005, 12:34am on 06/22/05 at 00:18:33, nani wrote:
IMHO and that of Clusterbusters, yes. 5 days if at all possible. And stay off it between the doses and after the dose(s) for as long as possible. Don't tell Glaxo I said that ;-) Bobw Speaking of movies, has anyone ever seen Scanners and felt empathy when the heads were exploding? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by nani on Jun 22nd, 2005, 12:39am on 06/22/05 at 00:34:33, Pinkfloyd wrote:
I haven't seen it, but I think I can sympathize. I kinda feel like that when I'm reading some of these threads. ::) ;;D |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Flash on Jun 22nd, 2005, 5:35am on 06/22/05 at 00:34:33, Pinkfloyd wrote:
Staying off trex after the dose is just as, if not more important IMO. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 27th, 2005, 2:28pm You can't really be serious. You just posted the biological half-life definition which says it's the time it takes the body to eliminate 1/2 the medication. The trex half life is 2 hours so my above post giving the elimination times is correct. Thanks for the help. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by BikerBob on Jun 27th, 2005, 2:42pm Questions about "half-life".... Let's use aspirin as an example... The plasma half-life for aspirin is approximately 15 minutes; that for salicylate lengthens as the dose increases: Doses of 300 to 650 mg aspirin have a half-life of 3.1 to 3.2 hours. Why is it that people who use aspirin as a blood thinner and to reduce the risk of stroke and angina don't take an aspirin every 3.2 hours? Although aspirin has a half-life of 3.2 hours, it's effect on blood thinning lasts about five days. How do you know that triptans do not have an effect on 5HT neural mechanisms for five days? BB |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 27th, 2005, 2:51pm They don't take it every 3.2 hours because it's only 1/2 gone by then. It takes weeks to get it up to theraputic levels. This is the same with verapamil. You take 120mg. 12 hours later that's down to 15mg left in your system but you then take another 120mg dose. Now you have 135mg in your system. At the end of another 12 hours you have 16.87mg left in your system. You take another 120mg. etc. etc. That's why it takes some time to reach theraputic levels and that's why people only take the asprin once a day. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by don on Jun 27th, 2005, 2:56pm Who's Mrs. Barlow? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by BikerBob on Jun 27th, 2005, 2:59pm on 06/27/05 at 14:51:35, Bob P wrote:
What is your source of information that leads you to believe that it takes weeks for aspirin to reach therapeutic levels? BB |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 27th, 2005, 3:40pm Granted, it's not an absolute. Verp has a half life of around 4 hours but when it's taken everyday the half life jumps to around 10 hours after only a few days. I'm not recomending any kind of waiting period. People can decide that for themselves. I was really just posting the half-life of trex, as printed in the medical info, for CC's information. Quote:
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by BikerBob on Jun 27th, 2005, 4:10pm BobP, you are wrong about aspirin taking weeks to reach therapeutic levels. Doses of 300 to 650 mg aspirin have a half-life of 3.2 hours. It's therapeutic effects begin to occur within an hour. Its anticoagulation effects last 8 days. Ibuprofen inactivates aspirins anticoagulation effect because it "competes for same receptors". Why is it so difficult for you to believe that triptans interfere with alternative therapy for 5 days? BB |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 28th, 2005, 7:05am Quote:
Why doesn't a shot of trex keep the attacks away for 5 days? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by vig on Jun 28th, 2005, 11:21am well, we've done a good job of showing that half-life has little or no relevance to the drug's effects and duration. that's a start. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 28th, 2005, 12:05pm Quote:
Hallucinating or just dilusional? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by floridian on Jun 28th, 2005, 12:35pm on 06/28/05 at 07:05:47, Bob P wrote:
A more interesting question is why do triptans seem to increase the frequency and intensity of cluster headaches, and prolong cycles. If triptans are so short acting, why might these negative consequences occur 24 - 48 hours after the last trex dose? Quote:
So aspirin has a permanent effect on platelets - regardless of its half-life. Platelets are less likely to coagulate once exposed to aspirin. And if the life of a platelet is 7-10 days, then there is a 10-15% turnover each day, and by the end of a week, most platelets would be new and sticky. Hence the need to take it daily, or every other day, or atleast with Sunday Dinner for Monday morning protection. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 28th, 2005, 2:03pm Quote:
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jun 28th, 2005, 3:36pm Quote:
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Margi on Jun 28th, 2005, 3:43pm you think it's funny to post here as two different people and lead people on to think that you are two sufferers who know each other? You think that lends anything to the credibility of ANY of your posts? OR to furthering research into the newer alternative cluster treatments? Wow. :( |
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Title: Re: Post by seasonalboomer on Jun 30th, 2005, 2:59pm "Others have told me that I have NOTHING to apologize for so eat me!" Which others, "Vicar2"? :o |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Margi on Jun 30th, 2005, 3:11pm Well, I promised "others" I wouldn't fan your flame by responding to your attention seeking posts. However, I will say that, yes, I am feeling better now, knowing that you're going on vacation. Hope you meet up with your brain somewhere along the way. And, uh, FYI, I don't have to have clusters to understand that you're an idiot. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Jonny on Jun 30th, 2005, 5:57pm on 06/30/05 at 14:48:58, jokrs2 wrote:
The master?....LMMFAO ;;D Like I posted in your "Good bye" thread. When people post my name they think "King" When your name is posted they think "Scumbag" ;;D Just how long do you think that I will watch you badger these people before I have your plug pulled from this site? The so called ball is in your court, Dumbass! |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Kevin_M on Jun 30th, 2005, 8:03pm on 06/30/05 at 17:57:14, Jonny wrote:
That gives you the green light joker. Yes, we'll keep the light on... Quote:
Kevin M |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by clarence on Jul 1st, 2005, 11:43am Joe, Way uncalled for dude. Margi is nothing but supportive of sufferers on this site. No reason to curse at her or call her names. That just isn't cool. :-/ Casey |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jul 2nd, 2005, 9:10pm Floridian: "A more interesting question is why do triptans seem to increase the frequency and intensity of cluster headaches, and prolong cycles. If triptans are so short acting, why might these negative consequences occur 24 - 48 hours after the last trex dose? " Quote:why might these negative consequences occur 24 - 48 hours after the last trex dose? on 06/28/05 at 14:03:29, Bob P wrote:
Sorry ..I forgot to answer this... : Headache. 2004 Jul;44(7):713-8. Related Articles, Links Subcutaneous sumatriptan induces changes in frequency pattern in cluster headache patients. Rossi P, Lorenzo GD, Formisano R, Buzzi MG. Objectives.-To document the relationship between the use of subcutaneous (SQ) sumatriptan (sum) and a change in frequency pattern of cluster headache (CH) in six patients. To discuss the clinical and pathophysiological implications of this observation in the context of available literature. Background.-Treatment with SQ sum may cause an increase in attack frequency of CH but data from literature are scant and controversial. Methods.-Six CH sum-naive patients (three episodic and three chronic according to the International Headache Society (IHS) criteria) are described. Results.-All six patients had very fast relief from pain and accompanying symptoms from the drug but they developed an increase in attack frequency soon after using SQ sum. In all patients, the CH returned to its usual frequency within a few days after SQ sum was withdrawn or replaced with other drugs. Five patients were not taking any prophylactic treatment and SQ sum was the only drug prescribed to treat their headache. Conclusions.-Physicians should recognize the possibility that treatment of CH with SQ sum may be associated with an increased frequency of headache attacks. ::) Have a great weekend everyone Bobw |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jul 5th, 2005, 9:58am Quote:
That answers the frequency but what about the intensity and prolonged cycles? |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by floridian on Jul 5th, 2005, 10:40am Well, there isn't double-blind placebo controlled study that shows whether trex does or does not influence the length of a cycle. But there is lots of anecdotal evidence, and according to pubgirl, experts including Dr. Goadsby believe that it probably does (or is possible that it does) increase the length of a cycle. Quite apart from half-lifes, administering a drug usually turns various genes off and others on. A very common effect of administering a neutotransmitter or hormone agonist (including nicotine, morphine, and corticosteroids) is that natural production of that chemical in the body decreases, and the number of receptors for it on the cell surface changes. This sets up a dependency - keep taking the drug, and things are semi-manageable; stop, and things get bad. Do triptans cause this type of dependency? Not sure at this point, but I believe they sometimes can, depending on the individual and the dose regimen. I'm not trying to ban triptans, just raising these issues to give people something to think about. Lots of people here have reported nasty cycles after their doc prescribed a triptan for them. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jul 5th, 2005, 1:36pm Quote:
I believe Prof. Goadsby said that about verapamil, not trex. |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by pubgirl on Jul 9th, 2005, 2:30am PG was asked his opinion at last year's conference,when asked a direct question, he tends to give rather direct answers even if he perhaps shouldn't! On the subject of verap, when asked if using it may make our condition worse, the answer was "yes", on the subject of triptans, the answer was "probably". Hope that helps Wendy |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jul 18th, 2005, 10:13am Since I was getting so many different answers to what PG said, I asked him directly. Here is his response: Quote:
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jul 18th, 2005, 1:02pm on 07/18/05 at 10:13:57, Bob P wrote:
"I believe Prof. Goadsby said that about verapamil, not trex. " LOL...one of those different answers was yours. Anyway, it seems what Wendy reported he'd said, was correct. Yes, Verapamil may make the condition worse, per Prof. Goadsby. What did he say about imitrex? Did you not ask, did he not answer or did you edit out his response on that? Just wondering what his response would have been since both were in question and I assumed you would have asked about both. If you did, and he didn't answer, I would find that interesting. Bobw |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Bob P on Jul 18th, 2005, 1:16pm LOL - yeah that's pretty funny Bob. Guess I was just buying into what someone else had said. You'd think I'd have learned my lesson regarding that from Flash's and other's posts. I e-mailed the Professor weeks ago regarding verap. He was out of the country, I beleve at the AHS gathering, so I just got the response. No I didn't ask about trex but I have a pretty good idea what the answer would be. Probably the same answer I would get if I asked if it was "possible" (key word here) the sky would fall tomorrow! Don't believe anything anyone tells you and only believe half of what you see! |
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Title: Re: Rivea Corymbosa (LSA) Tonights Test Post by Pinkfloyd on Jul 19th, 2005, 12:44am on 07/18/05 at 13:16:03, Bob P wrote:
Half? Man you are gullible. Want to play some poker? My internet believe-o-meter only goes to 18% and I have to give it a whack just to get it that high. :-/ Bobw |
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