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        New Message Board Archives >> Medications, Treatments, Therapies 2005 >> Melatonin--confirmation of benefits
        
(Message started by: Bob_Johnson on May 25^th, 2005, 9:57am)

Title: Melatonin--confirmation of benefits
Post by Bob_Johnson on May 25^th, 2005, 9:57am

Cephalalgia. 2005 Jun;25(6):403-11.

Melatonin, the pineal gland and their implications for headache disorders.

Peres M.

Brain Research Institute, Albert Einstein Hospital, Sao Paulo, Brazil.

Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia 2005. London. ISSN 0333-1024There is now evidence that melatonin may have a role in the biological regulation of circadian rhythms, sleep, mood, and ageing. Altered melatonin levels in cluster headache and migraine have been documented. Melatonin mechanisms are related to headache pathophysiology in many ways, including its anti-inflammatory effect, toxic free radical scavenging, reduction of proinflammatory cytokine up-regulation, nitric oxide synthase activity and dopamine release inhibition, membrane stabilization, GABA and opioid analgesia potentiation, glutamate neurotoxicity protection, neurovascular regulation, serotonin modulation, and the similarity of chemical structure to that of indomethacin. Treatment of headache disorders with melatonin and other chronobiotic agents is promising. A double-blind, placebo-controlled trial shows melatonin is effective in cluster headache prevention, other studies also show benefit in other disorders. Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment.

PMID: 15910564

Title: Re: Melatonin--confirmation of benefits
Post by Pinkfloyd on May 25^th, 2005, 10:56am

on 05/25/05 at 09:57:27, Bob_Johnson wrote:

Cephalalgia. 2005 Jun;25(6):403-11.
A double-blind, placebo-controlled trial shows melatonin is effective in cluster headache prevention, other studies also show benefit in other disorders. Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment.

PMID: 15910564

Proof of how slowly these things can progress....

"Melatonin And Cluster Headaches"
In this study, 10 mg of melatonin was administered to half of 20 cluster-headache patients in a double-blind controlled study that lasted 14 days. Headache frequency was significantly reduced in the
melatonin treatment group. Five of 10 people in the melatonin group reported that their attack frequency declined after only 30-35 days of treatment. No patient in the placebo group responded."
Cephalalgia (Vol 16, Issue 7 1996)

9 years later, it offers new avenues ;-)
It is good to see though that "they" are following up on this.

Bob,
Do you know if this was quoting the study from '96 or was this based upon a new study of melatonin and clusters?

thanks,
Bobw

Title: Re: Melatonin--confirmation of benefits
Post by JJA on May 25^th, 2005, 11:45am

I just checked it out. It's the same old '96 paper.
It also mentions this one where melatonin helps two people with chronic refractive CH:
Peres MF, Rozen TD. Melatonin in the preventive treatment
of chronic cluster headache. Cephalalgia 2001;
21:993–5.

Jesse

Title: Re: Melatonin--confirmation of benefits
Post by floridian on May 25^th, 2005, 5:56pm

Yay for melatonin!!

There are 28 citations on Pubmed that include both "cluster headache" and "melatonin" - though not all are studies, most are lists of therapies that have been used.

Title: Re: Melatonin--confirmation of benefits
Post by Bob P on May 25^th, 2005, 6:26pm

I tried it this cluster. 9mg / night for 5 or 6 weeks. Didn't do anything (but I may have done it wrong).

I quit taking it this past weekend and I think I'm sleeping better than I did while taking it.

Title: Re: Melatonin--confirmation of benefits
Post by Marc on May 25^th, 2005, 10:20pm

Of course you took it all wrong Bob!

Marc

Title: Re: Melatonin--confirmation of benefits
Post by Pinkfloyd on May 26^th, 2005, 12:36am

on 05/25/05 at 10:56:07, Pinkfloyd wrote:

"Melatonin And Cluster Headaches"
In this study, 10 mg of melatonin was administered to half of 20 cluster-headache patients in a double-blind controlled study

on 05/25/05 at 18:26:45, Bob P wrote:

I tried it this cluster. 9mg / night for 5 or 6 weeks. Didn't do anything (but I may have done it wrong).

What makes you think you did anything wrong Bob?
Stop beating yourself up like that. ;;D

Bobw

Title: Re: Melatonin--confirmation of benefits
Post by Mr. Happy on May 26^th, 2005, 12:56am

Bob, Bob and Bob.........

Bob (not Bob or Bob) screwed up. He only took 9 mg instead of the directed 10.
I don't know whether to listen to Bob, Bob, or Bob. Melatonin did nuthing for me, unless it made me sleep like crap. Like Bob, but not Bob or Bob.

I'm losing my mind.....
RJ

Title: Re: Melatonin--confirmation of benefits
Post by Bob P on May 26^th, 2005, 7:02am

I'm thinking that since melatonin is an indole that the shrooms probably interfered with the melatonin.

Seriously, even before I was in cycle I would take mel before bed occasionally. 1.5mg would help me sleep. 3mg would interfere with sleep, shorter an more restless sleep. 9mg didn't seem to do anything. Can the cluster brain be that messed up?

Title: Re: Melatonin--confirmation of benefits
Post by Bob_Johnson on May 26^th, 2005, 7:40am

Bob P has it right. A good study reported on Medscape showed that, for sleep, a dose of 0.3mg was best. Using more or less--for sleep--was less effective.

Title: Re: Melatonin--confirmation of benefits
Post by vig on May 26^th, 2005, 7:48am

You know, if anybody was playing 'Hi Bob' right now, they'd be really drunk.
8)