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        New Message Board Archives >> Medications, Treatments, Therapies 2005 >> Mitral-valve prolapse(MVP) and Meds
        
(Message started by: lionsound on Jan 20^th, 2005, 11:41am)

Title: Mitral-valve prolapse(MVP) and Meds
Post by lionsound on Jan 20^th, 2005, 11:41am

Does any one else here have MVP? (mitral valve prolapse)

I do and with a recent increase in verapamil it's gone a little nutty. My heart was doing funky dances for at least a few hours last night.

I added 80mg of verap at night exactly a week ago to my already 240 in the morning. I do not take anything for the MVP.

Has anyone else found a reaction to meds this way?

Thanks in advance :)
-lionsound

Title: Re: Mitral-valve prolapse(MVP) and Meds
Post by floridian on Jan 20^th, 2005, 12:02pm

There is some research linking mitral valve prolapse to low magnesium levels - the thinking is that low magnesium levels lead to weakened connective tissue on the heart valve, allowing it to 'flop'. Magnesium is commonly used to treat some types of irregular heart rhythms. Also has been shown that magnesium can help some with clusters and migraines. Low magnesium is associated with an impaired autonomic nervous system (anxiety, sympathetic dominance, etc).

If you are already on verap or other meds and having some arrythmia, talk to your doctor before adding magnesium. (I know you well enough so that I don't have to say that, but I will any way!)

http://www.ctds.info/mvp1.html

Quote:

Magnes Res. 2004 Mar;17(1):39-45.

Is magnesium deficit in lymphocytes a part of the mitral valve prolapse syndrome?

Kitlinski M, Stepniewski M, Nessler J, Konduracka E, Solarska K, Piwowarska W, Erhardt L. Department of Cardiology, University of Lund, Malmo University Hospital MAS, Malmo, Sweden. mariusz.kitlinski@telia.com

Magnesium deficiency has been proposed to be related to the mitral valve prolapse syndrome. However determinations of magnesium concentration in blood serum and hemolysates of red blood cells in this disease revealed divergent results. We investigated 49 patients with the mitral valve prolapse syndrome and 30 healthy individuals, matched by age and gender. The concentration of magnesium was measured in blood plasma and lysates of lymphocytes isolated from venous blood. The magnesium concentration in plasma was similar in both the patients and the healthy controls. By contrast, the magnesium concentration in lysates of lymphocytes was significantly lower (p < 0.03) in the patients with mitral valve prolapse syndrome than in the controls (range: 1.94-10.6 mmol/g of protein in Lymphocyte lysate; median 5.98 and 6.7-9.61 mmol/g of protein; median 7.22). The results obtained suggest that magnesium deficiency may be part of the mechanisms of the mitral valve prolapse syndrome.

Quote:

Pol Merkuriusz Lek. 2003 Mar;14(81):220-3. Related Articles, Links

[Influence of autonomic nervous system on electrolyte abnormalities in children with mitral valve prolapse]

[Article in Polish]

Bobkowski W, Zachwieja J, Siwinska A, Mrozinski B, Rzeznik-Bieniaszewska A, Maciejewski J.

Klinika Kardiologii i Nefrologii Dzieciecej Akademii Medycznej w Poznaniu. wbobk@mp.pl

Measurement of the heart rate variability enables to assess the activity of the autonomous nervous system. The aim of the study was to evaluate the possible relationship between clinical status, serum sodium (Na), potassium (K), calcium (Ca), magnesium concentrations and HRV in children with mitral valve prolapse. The study group consisted of 151 children with MVP (age +/- SD: 12.2 +/- 3.1 years). Thirty patients out of the MVP group were symptomatic and 121 were asymptomatic. The total number of 165 healthy children (age +/- SD: 12.3 +/- 3.7 years) were included into the control group. We assessed power spectrum of HRV (low frequency component--LF, high frequency component--HF, and LF/HF ratio) from 5-minute recording during daytime and night. Serum Mg (p < 0.00001) and K (p < 0.03) concentrations were significantly lower in MVP group as compared to healthy children. A marked decrease in Mg concentration was observed in symptomatic children with MVP as compared to asymptomatic patients (p < 0.0001). A significant positive correlation was found between Mg concentration and HF and HF n.u. components (daytime and night) and significant negative correlation was observed between Mg concentration and LF and LF n.u. (daytime and night) parameters and LF/HF ratio (daytime and night). Symptomatic children with MVP had significantly higher LF n.u. and LF/HF ratio and a lower HF n.u. as compared to asymptomatic patients. The autonomic changes in MVP children (reduction in parasympathetic tone with sympathetic predominance) were associated with decreased serum Mg concentration and higher prevalence of clinical symptoms. Mg supplementation seems to be a prudent approach in symptomatic children with MVP.

Title: Re: Mitral-valve prolapse(MVP) and Meds
Post by lionsound on Jan 20^th, 2005, 5:16pm

Thanks Floridian :)

I already take 500mg of Magnesium daily(since august of last year). So I doubt more would be more helpful.

I did not now about the connection to MVP.

It was suggested that I take it by my Headace Doc.