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        New Message Board Archives >> Medications, Treatments, Therapies 2004 >> Another beauty from Guest Book
        
(Message started by: pubgirl on Aug 15^th, 2004, 4:39pm)

Title: Another beauty from Guest Book
Post by pubgirl on Aug 15^th, 2004, 4:39pm

This is a new one from the Guest Book

"If this can help anyone, 2 things that I discover after 22 years of Cluster. First, one of the trigger for my headache is crude onion and second is that Boldo tea (Peumus boldus) reduce/cancel the crises just when the cycle starts"

Thanks Jaime!

I will avoid crude onions and drink Boldo tea from now on.
Crude people might be harder to avoid ;;D

Wendy

(I'll let Floridian dissect the active ingredients of Boldo Tea http://www.raintree-health.co.uk/cgi-bin/getpage.pl?/plants/boldo.html)

Title: Re: Another beauty from Guest Book
Post by don on Aug 15^th, 2004, 5:21pm

Quote:

crude onion

As opposed to a refined and well mannered onion?

Title: Boldo
Post by floridian on Aug 15^th, 2004, 5:51pm

I'm not familiar with boldo, but here are a few quick excerpts. In addition to having a load of anti-oxidants, it contains an alkaloid called boldine, which is rather interesting.

A Calcium Channel modifier

Quote:

When tested with isolated sarcoplasmic reticulum membrane vesicles, boldine dose-dependently induced Ca2+ release from actively loaded sarcoplasmic reticulum vesicles isolated from skeletal muscle of rabbit or rat which was inhibited by ruthenium red, suggesting that the release was through the Ca2+ release channel, also known as the ryanodine receptor.

Anti-spasm activity/Anti-nicotine effect (not sure about the toxicity of something that is similar to curare - probably occurs in low dose, but not sure - more digging needed).

Quote:

In addition, boldine was similar to d-tubocurarine in its action to reverse the neuromuscular blocking action of alpha-bungarotoxin. These results showed that the neuromuscular blockade by boldine on isolated mouse phrenic-nerve diaphragm might be due to its direct interaction with the postsynaptic nicotinic acetylcholine receptor.

Anti-inflammatory

Quote:

boldine is an effective inhibitor of prostaglandin biosynthesis, promoting 53% inhibition at 75 microM. The latter in vitro effect may be mechanistically linked to the anti-inflammatory and antipyretic effects of boldine exerted in vivo.

May reduce the breakdown of testosterone and other molecules in the body, increase glutathione anti-oxidants

Quote:

Boldine manifested inhibition activity on hepatic microsomal CYP1A-dependent 7-ethoxyresorufin O-deethylase and CYP3A-dependent testosterone 6 beta-hydroxylase activities and stimulated glutathione S-transferase activity in Hepa-1 cells.

Title: Onions
Post by floridian on Aug 15^th, 2004, 6:33pm

If onions make your eyes sting and your nose water, they could be triggering the release of substance P and other inflammatory compounds. In the short run, when susceptible, this could trigger a cluster headache.

In the long run, onions are probably a good thing. Onions are loaded with bioflavonoids like quercetrin and quercetin. These are on par with cromolyn in terms of reducing mast cell degranulation (the release of histamine). Cromolyn and quercetrin take a week or so of dosing before the full effect kicks in - these are very different from histamine blockers in terms of how they work, although the net effect is less inflammation. Cooking the onions eliminates the pungency without zapping the flavonoids.

Title: Re: Another beauty from Guest Book
Post by UN_SOLVED on Aug 15^th, 2004, 7:02pm

Sometimes I eat lots of onions ... sometimes I don't eat them at all. I've never found any connection as far as attack frequency or intensity. ??

Never had any Boldo Tea though ... what the he77 is that ?? ( Now i'll have to look it up ! )

Unsolved