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        New Message Board Archives >> Medications, Treatments, Therapies 2004 >> Melatonin, body temperature, circadian rhythm
        
(Message started by: CJohnson on Jan 5^th, 2004, 10:36am)

Title: Melatonin, body temperature, circadian rhythm
Post by CJohnson on Jan 5^th, 2004, 10:36am

Melatonin supplementation lowers core body temperature and can change your circadian rhythm. Find the right dosage and maybe you can tune your circadian rhythm right out of the "in cycle" state. Probably contraindicated with psilocin since it is also tuning your circadian rhythms and is also an indole. Also, beware of lowering your body temperature if you are fighting a cold or infection or are at increased risk for cold or flu or infection etc.... Who knows, ask your doctor.

Acute phase-shifting effects of melatonin associated with suppression of core body temperature in humans.

Deacon S, English J, Arendt J.

Endocrinology and Metabolism Group, School of Biological Sciences, University of Surrey, Guildford, UK.

Appropriately administered melatonin is able to phase shift circadian rhythms, to induce transient sleepiness and to suppress core body temperature. The relationships between these phenomena have not been fully explored. In a double-blind, placebo-controlled crossover study, 8 healthy males maintained a regular sleep-wake cycle in a natural environment throughout. From dusk until 2400 h on days (D) 1-4 subjects were in dim artificial lighting (< 100 lux) with darkness (< 1 lux) from 2400-0800 h. Sunglasses were worn during the day when outside. At 1700 h on D3 either melatonin (5 mg) or placebo was administered. Saliva samples were collected at 30 min intervals, 1600-2400 h on D3 and D4, and subjective alertness rated at 30 min intervals from 1600-2400 h on D3 and hourly from 0800-2400 h D4. Sleep quality was rated on nights 2, 3 and 4 and core temperature was recorded throughout. Melatonin induced a significant suppression of temperature and alertness peaking 2.5 h after the dose, together with improved sleep quality on the night of D3 and a phase advance of the endogenous melatonin rhythm on D4. The degree of phase shift was related to the amount of temperature suppression in 6 of 7 subjects with detectable melatonin, suggesting that temperature suppression is an integral part of the phase-shifting mechanism.

Publication Types:
Clinical Trial
Controlled Clinical Trial

PMID: 7816333 [PubMed - indexed for MEDLINE]

PFDANs
-Curtis

Title: Re: Melatonin, body temperature, circadeaon rhythm
Post by t_h_b on Jan 5^th, 2004, 9:33pm

On my first visit to my neurologist, he asked me if I am hot-natured. (I am very much so.) Melatonin is effective for me in preventing CH.