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        New Message Board Archives >> Medications, Treatments, Therapies 2003 >> New Med for CH servay in Holland
        
(Message started by: joke ten dam on Jul 18^th, 2003, 12:44am)

Title: New Med for CH servay in Holland
Post by joke ten dam on Jul 18^th, 2003, 12:44am

:) :D ;D
The LUMC (Leids Universitair Medisch Centrum) is doing a study on a new preventive medication called Civamide.
::)I will keep you posted on how it will fair. The preliminary triels were very succesful with few short lasting sideeffects. ;D
By. By Joke ten Dam

Title: Re: New Med for CH servay in Holland
Post by Georgia on Jul 18^th, 2003, 2:17am

Joke - Civamide is drug that was being used in the CH clinical trial that was posted on the General Board for so long. Please let us know what the study there determines.

Arch Neurol. 2002 Jun;59(6):990-4. Related Articles, Links

Intranasal civamide for the treatment of episodic cluster headaches.

Saper JR, Klapper J, Mathew NT, Rapoport A, Phillips SB, Bernstein JE.

Michigan Headache Pain and Neurological Institute, 3120 Professional Dr, Ann Arbor, MI 48104, USA.

OBJECTIVE: To evaluate the safety and efficacy of intranasal civamide solution for preventive treatment during an episodic cluster headache period. SUBJECTS AND METHODS: This was a multicenter, double-blind, randomized, vehicle-controlled study with a 7-day treatment period and a 20-day posttreatment period performed at 14 headache/neurology centers in the United States. Twenty-eight subjects were randomized to receive civamide or its vehicle in a 2:1 ratio; 18 received civamide and 10 received the vehicle. Subjects received 100 microL of 0.025% civamide (25 microg) or 100 microL of the vehicle to each nostril via dropper once daily for 7 days. The total daily dose of civamide was 50 microg. MAIN OUTCOME MEASURES: The number of cluster headaches per week during the treatment and posttreatment periods, pain intensity, presence of associated symptoms, and the incidence of adverse events were assessed. RESULTS: Subjects in the civamide group had a significantly greater percent decrease in the number of headaches from baseline to posttreatment during days 1 through 7 (-55.5% vs -25.9%; P =.03) and a trend toward significance during days 8 through 14 (-66.9% vs -32.3%; P =.07) and days 15 through 20 (-70.6% vs -34.9%; P =.07), as well as a near-significant decrease during the entire posttreatment period (days 1 through 20 [P =.054]) compared with the vehicle group. There were larger decreases in the number of headaches per week during the posttreatment period in the civamide-treated group, with trends toward significance during posttreatment days 8 through 14 (-8.6 vs -3.6; P =.09) and days 15 through 20 (-8.9 vs -3.6; P =.07). There were no significant differences between groups in cluster headache pain intensity, number of severe headaches, or associated symptoms. The most common adverse events included nasal burning (14 of 18 civamide-treated subjects, 1 of 10 vehicle-treated subjects; P =.001) and lacrimation (9 of 18 civamide-treated subjects, 0 of 10 vehicle-treated subjects; P =.01). CONCLUSION: Intranasal civamide solution at a dose of 50 microg may be modestly effective in the preventive treatment of episodic cluster headache.

Title: Re: New Med for CH servay in Holland
Post by joke ten dam on Jul 18^th, 2003, 2:46am

:D thanks Giorgia,
I have sent your info to Frans, the Duch Ouch establisher. I have asked him to translate it and post it on th dutch CH site. My spelling and translating skills are somewhat temperd bij my ches.
I will keep you posted,
Joke ten Dam

Title: Re: New Med for CH servay in Holland
Post by cbolony on Jul 18^th, 2003, 4:37pm

Quote:

The most common adverse events included nasal burning (14 of 18 civamide-treated subjects

Georgia i did the trial it felt like someone put a lite match in your two nasal had to do it for seven days two times aday did not help me.But if you want to clean out your sinus this drug is for you :)

Title: Re: New Med for CH servay in Holland
Post by Georgia on Jul 18^th, 2003, 9:24pm

CB - Yikes. That doesn't sound like any fun. If it worked though - shit, I'd put a propane torch up my nose twice a day to stop these bastards. At least they are trying something focused toward CH.

Title: Re: New Med for CH servay in Holland
Post by JDH on Jul 18^th, 2003, 11:54pm

on 07/18/03 at 16:37:42, cbolony wrote:

Ditto CB.
I went through the same trial and was glad to get out with my nose intact. And, it did nothing for the CH's

Jim