Clusterheadaches.com Message Board


    
      
        Clusterheadaches.com Message Board
        (http://www.clusterheadaches.com/cgi-bin/yabb/YaBB.cgi)
      

        New Message Board Archives >> Medications, Treatments, Therapies 2003 >> "Any" clinical trials or med journals on shrooms?
        
(Message started by: athos12 on Mar 20^th, 2003, 1:57am)

Title: "Any" clinical trials or med journals on shrooms?
Post by athos12 on Mar 20^th, 2003, 1:57am

"Any" clinical trials or med journals on shrooms?

I am trying to get all of the information that I can find.

The pharmacology and toxicology of shrooms and how they actually effect the CH, and if there is any medical documentation to support it?

Thanks

Athos

Title: Re: "Any" clinical trials or med journals on shroo
Post by ave on Mar 20^th, 2003, 6:42am

Athos, if you haven't already, check out

http://www. geocities.com/ClusterBusters2002

otherwise, try www.maps.org

Lots if info there

Title: Re: "Any" clinical trials or med journals on shroo
Post by tommyD on Mar 20^th, 2003, 9:56am

Athos -

There are no recent clinical trials or studiers of the effectiveness of psilocin on cluster headaches. The US government, at least, makes it very difficult to conduct such studies, and the pharmaceutical companies don't see enough profit potential to invest in research.

However --

There are studies from decades ago that show indole ring hallucinogens, such as psilocin and LSD, to be very effective in the relief of vascular headaches. Now those studies looked at LSD in the treatment of - dare I say the word? - migraines.

In fact, the legend is that Dr. Albert Hoffman, the Sandoz researcher who invented LSD, was looking for a treatment for migraines when he combined diethyl amide with an ergot derivative called lysegic acid. Then he got some on his fingers and had a very interesting experience...

And there are some solid theories as to why and how indole ring hallucinogens may affect serotonin levels and their effect on the hypothalamus.

I think you can find these theories on the websites Ave mentioned.

-tommyD

Title: Re: "Any" clinical trials or med journals on shroo
Post by BobG on Mar 20^th, 2003, 3:59pm

Here's some more shroom stuff to click on.

http://home.attbi.com/~rwold350/index.html
‘schroom web site from PinkFloyd

http://clusterheadaches.com/wwwboard/messages/82778.html
discussion thread on the good and bad of ‘schroom use for clusters

http://clusterheadaches.com/wwwboard/messages/91050.html
pinksharkmark 5-7-01 “meds and mushrooms” drugs to avoid with schrooms

http://clusterheadaches.com/wwwboard/messages/82900.html
pinksharkmark (3-16-01 Hallucinogenic research)

Title: Re: "Any" clinical trials or med journals on shroo
Post by michaelc on Mar 20^th, 2003, 4:16pm

this is clipped from another posting i made last night -

Some of you may already know that there is a clinical trial underway at PRESENT - Approved by the FDA ;D to treat patints with OCD (obsessive compulsive disorder) with psilocybin. Unlike ECH, OCD patients require a full-dose psychedelic trip to relieve their symptoms. If anyone is wondering, in spite of taking a hefty dose, no one at the trial has had any problems with the psychedelic effects so far.

Since there is a growing body of antecdotal evidence on this BBS for psilocin and ECH, it might be possible to get this one on the next trial, especially if the OCD trials yeild positive results. The prblem is money - MAPS barely scraped together the funding for the OCD research.

Part of the point of mentioning that is to let concerned group members know that the FDA feels psilocybin has enough potential for testing, and is 'generally' considered safe by medical specialists familiar with pschedelic research.

for more information in this gov't APPROVED clinical psilocybin trial visit the MAPS website at www.maps.org
and specifically http://www.maps.org/research/index.html#PSILOCYBIN

Title: Re: "Any" clinical trials or med journals on shroo
Post by athos12 on Mar 20^th, 2003, 7:38pm

Thanks for the info... I wish I could get on medline and do a search... anyone here with access to medline?

I am going to my neuro tomorrow, he wanted some more info on shrooms.... I would like to get my hands on the research done in the 60's..

Athos

Title: Re: "Any" clinical trials or med journals on shroo
Post by michaelc on Mar 20^th, 2003, 8:53pm

Check Here athos ..... dozens psychedelic research abstracts from the 1950s-70s

http://www.psychedelic-library.org/thermenu.htm

also check the Albery hoffman Library papers

http://www.hofmann.org/papers/index.html

hope this is of help,
michael

Title: Re: "Any" clinical trials or med journals on shroo
Post by michaelc on Mar 20^th, 2003, 9:46pm

did some more research - here's a few your doc might be able to relate to.

http://www.biopsychiatry.com/psilocybin.htm
unfortunately this one describes the psychedelic side-effects as 'psychosis' lol, which i can personally attest is not the case, except in the case of a very high-dose 'bad-trip'. Moderate changes in perception are not psychosis.

http://www.maps.org/news-letters/v07n1/07110bag.html
(1996); Increased activation of indirect semantic associations under psilocybin. Biol Psychiatry 39:1055-1057.

IMPORTANT: "equal, aspertame, diet sodas, etc"
PHENETHYLAMINE MAY CONTRIBUTE TO ADVERSE REACTION TO HALLUCINOGENIC PSILOCYBE MUSHROOM INGESTION
http://www.tiaft.org/tiaft97/proceedings/abstract/posters/083.html

'Psilocybin; It's Chemistry, Route of Access, and The Synaptic Transmitters It Effects: Scott Stephansky'
&
'Inhibitory and Excitatory Effects, and the Ion Channels effected by Psilocybin: Corey Fisher
http://sorrel.humboldt.edu/~morgan/psil_s01.htm

~michael

Title: Re: "Any" clinical trials or med journals on shroo
Post by das on Mar 21^st, 2003, 3:46pm

Here's some personal research. Shrooms works for me. There are no lasting effects or side effects that I know of . Do not take them if you are a nervous or anxious person in general. If you aren't, and you have no other experience with drugs such LSD or THC than just take a .5 of a gram, put some chill music on and relax. The good thing is that the effect only lasts for 2-3 hours, but .5 gram will barely hit you, unless they are really strong.

Good Luck

Title: Re: "Any" clinical trials or med journals on shroo
Post by athos12 on Mar 21^st, 2003, 4:04pm

Thanks for all of the info... my neiro is very open minded about it, he took all the info that I gathered and was impressed.... I also have talked with a pharmacological research guy that is "somewhat" interested in what I told him.....

--Athos