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        Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Help please-can't find info on olazapine
        
(Message started by: kcopelin on Apr 15^th, 2008, 11:34am)

Title: Help please-can't find info on olazapine
Post by kcopelin on Apr 15^th, 2008, 11:34am

Hey y'all, I'm going to see a new neuro in about 3 hours. I printed the info on olazapine to take with me and now canot find that or the reference here. Any one? Can ya help please.

Thanks,
kathy

Title: Re: Help please-can't find info on olazapine
Post by purpleydog on Apr 15^th, 2008, 12:04pm

Kathy,
I don't know where there is a link to olanzapine, but you may search on Zyprexa, that's the brand name.

Title: Re: Help please-can't find info on olazapine
Post by purpleydog on Apr 15^th, 2008, 12:10pm

http://www.ouch-us.org/medications/zyprexa.htm

http://www.ncbi.nlm.nih.gov/pubmed/11576207

http://www.blackwell-synergy.com/doi/abs/10.1046/j.1526-4610.2001.01148.x?cookieSet=1&journalCode=hed

Hope these help. They seems to have the same info by Dr. Todd Rozen.

Title: Re: Help please-can't find info on olazapine
Post by Bob_Johnson on Apr 15^th, 2008, 12:15pm

Headache 2001 Sep;41(8):813-6

Olanzapine as an Abortive Agent for Cluster Headache.

Rozen TD.

Department of Neurology, Jefferson Headache Center/Thomas Jefferson University Hospital, Philadelphia, Pa.

OBJECTIVE: To evaluate olanzapine as a cluster headache abortive agent in an open-label trial. BACKGROUND: Cluster headache is the most painful headache syndrome known. There are very few recognized abortive therapies for cluster headache and fewer for patients who have contraindications to vasoconstrictive drugs. METHODS: Olanzapine was given as an abortive agent to five patients with cluster headache in an open-label trial. The initial olanzapine dose was 5 mg, and the dose was increased to 10 mg if there was no pain relief. The dosage was decreased to 2.5 mg if the 5-mg dose was effective but caused adverse effects. To be included in the study, each patient had to treat at least two attacks with either an effective dose or the highest tolerated dose. RESULTS: Five patients completed the investigation (four men, one woman; four with chronic cluster, one with episodic cluster). Olanzapine reduced cluster pain by at least 80% in four of five patients, and two patients became headache-free after taking the drug. Olanzapine typically alleviated pain within 20 minutes after oral dosing and treatment response was consistent across multiple treated attacks. The only adverse event was sleepiness. CONCLUSIONS: Olanzapine appears to be a good abortive agent for cluster headache. It alleviates pain quickly and has a consistent response across multiple treated attacks. It appears to work in both episodic and chronic cluster headache.

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Olanzapine has a brand name of "Zyprexa" and is a antipsychotic. Don't be put off by this primary usage. Several of the drugs used to treat CH are cross over applications, that is, drugs approved by the FDA for one purpose which are found to be effective with unrelated conditions--BJ.

Title: Help please-can't find info on olazapine
Post by clavers on Apr 15^th, 2008, 12:43pm

I tried this drug some time ago. It is effective, sometimes, in aborting an attack, but in my case, four hours after taking it I went to sleep. It really knocked me out. Then, the next day, I was like a zombie. I decided to stick to other abortives.

Title: Re: Help please-can't find info on olazapine
Post by kcopelin on Apr 15^th, 2008, 1:35pm

Thanks!!!! I have tried all the other abortives-O2 works however the CH returns within 20 mins of stopping the O2. Am hoping this will give some more longlasting relief...in conjunction with the O2.

Hope this neurologist will listen to me and at least look at the research.

PFDAN
kathy