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        Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Baclofen
        
(Message started by: EstieSA on Dec 19^th, 2007, 1:08pm)

Title: Baclofen
Post by EstieSA on Dec 19^th, 2007, 1:08pm

[smiley=huh.gif]

Anybody here using it / used it previously ?

Title: Re: Baclofen
Post by Bob_Johnson on Dec 19^th, 2007, 9:49pm

Curr Pain Headache Rep. 2001 Feb;5(1):79-82.
The use of baclofen in cluster headache.

Hering-Hanit R, Gadoth N.

Department of Neurology, Meir General Hospital, Sapir Medical Center, 59 Jabotinski Street, Kfar Saba 44288, Israel.

Cluster headache is a rare, clinically well-characterized disabling disorder that occurs in both episodic and chronic forms. The very painful short-lived unilateral headache attacks are associated with autonomic dysfunction. A large number of drugs such as ergotamines, steroids, methysergide, lithium carbonate, verapamil, valproate, capsaicin, leuprolide, clonidine, methylergovine maleate, methylphenidate, and melatonin are considered beneficial for prophylaxis. Nevertheless, this extremely painful condition is occasionally refractory to conventional treatment. The antispastic agent baclofen has been shown to possess an antinociceptive activity. Its efficacy in neuralgias, central pain following spinal lesions, painful strokes, migraine, and medication misuse chronic daily headache suggests that it may be useful for prevention of cluster headache attacks. Therefore, we treated 16 symptomatic patients with cluster headache with daily baclofen, 15 to 30 mg, in three divided doses for the cluster period and 2 weeks after. Within a week, 12 patients reported the cessation of attacks. One was substantially better and became attack free by the end of the following week. In the remaining three patients, the attacks worsened and corticosteroids were prescribed. One of these was also given verapamil. Three of the 16 patients had an additional cluster period, which cleared with a second course of baclofen. In this pilot study, baclofen seemed to be effective, safe, and well tolerated for cluster headache, and seemed to retain its efficacy on repeated clusters.

Publication Types:
Clinical Trial

PMID: 11252142 [PubMed]

Title: Re: Baclofen
Post by Gator on Dec 20^th, 2007, 9:54am

I tried it a couple years ago. The recommended dose for ch is up to 30mg. When that didn't work, my neuro had me push it up to 80 mg. Still didn't work for me.

Title: Re: Baclofen
Post by totka2 on Dec 20^th, 2007, 2:47pm

I tried it last year at 75 mg/day. Cheap but ineffective.

Title: Re: Baclofen
Post by EstieSA on Dec 21^st, 2007, 11:48am

Can it be taken with other meds , ie Cymbalta & Topamax... [smiley=huh.gif]

Title: Re: Baclofen
Post by Gator on Dec 21^st, 2007, 12:12pm

Talk to your doctor, pharmacist and do some research on your own. This website has a drug interaction checker:

http://www.drugdigest.org/DD/Home

It didn't show any interaction between the three.

Title: Re: Baclofen
Post by EstieSA on Dec 21^st, 2007, 2:10pm

on 12/21/07 at 12:12:19, Gator wrote:

Talk to your doctor...

Thanks for the info ! I like to have my facts straight when visiting my doctor! ;)