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        Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Chronic CH--new treatment??--Clomiphene
        
(Message started by: Bob_Johnson on Dec 19^th, 2007, 11:45am)

Title: Chronic CH--new treatment??--Clomiphene
Post by Bob_Johnson on Dec 19^th, 2007, 11:45am

Just a trial but something to watch.......
--------------------
Headache. 2007 Dec 7 [Epub ahead of print]
Clomiphene Citrate for Treatment Refractory Chronic Cluster Headache.

Rozen T.

Michigan Head Pain and Neurological Institute, Ann Arbor, MI, USA.

A treatment refractory chronic cluster headache patient is presented who became cluster-free on clomiphene citrate. The author has previously reported a SUNCT patient responding to clomiphene citrate. Hypothalamic hormonal modulation therapy with clomiphene citrate may become a new preventive choice for trigeminal autonomic cephalalgias. The possible mechanism of action of clomiphene citrate for cluster headache prevention will be discussed.

PMID: 18070056

Title: Re: Chronic CH--new treatment??--Clomiphene
Post by Ray on Dec 19^th, 2007, 5:22pm

Any port in a storm, but anabolic steroids? I don't know that I would want to be taking them....

Ray

Title: Re: Chronic CH--new treatment??--Clomiphene
Post by Miz_D on Dec 19^th, 2007, 8:58pm

er....haha...I'm sure its just the menopause but can anyone translate this for me???[smiley=laugh.gif]

Danielle

Title: Re: Chronic CH--new treatment??--Clomiphene
Post by Ray on Dec 20^th, 2007, 12:15am

Danielle:

I'll try. It's a drug that is often given to women who are infertile. It tells the body that there isn't enough estrogen in the system and causes the body to produce more. The hypothalamus is thought to malfunction with cluster headaches and this drug is thought to change the way it functions.

It seems as though it helped one person who was not helped by any other means (refractory) with chronic cluster headaches and one with SUNCT.

These results imply to me that more research is needed and is another thing to try in some refractory cases.

Did that make any sense?

Ray

PS This explanation is subject to corrections by others who are more in the know than I.

Title: Re: Chronic CH--new treatment??--Clomiphene
Post by monty on Dec 20^th, 2007, 5:39pm

More research is always needed. I think federal law requires those words to be added to all studies. ;)

The effects are probably quite different in men than women. It blocks estrogen and increases gonadotropin-releasing hormone. In men, this probably increase testosterone. In women, it is more likely to increase FSH and LH.

Body builders also sometimes use this in their cycles to prevent bitchtits.

Title: Re: Chronic CH--new treatment??--Clomiphene
Post by EstieSA on Dec 21^st, 2007, 3:09am

on 12/20/07 at 17:39:09, monty wrote:

Body builders also sometimes use this in their cycles to prevent bitchtits.

;;D

Nobody wants those , right ? ;)