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        Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Trexima
        
(Message started by: BikerBob on Feb 24^th, 2006, 2:32pm)

Title: Trexima
Post by BikerBob on Feb 24^th, 2006, 2:32pm

pinkfloyd wrote:

Quote:

Much of the research going on was being funded by the large pharmaceutical companies, as we know. With the patents running out on imitrex, its obvious that glaxo is doing what they can to save their market share. They are researching a new imitrex tablet that is coated with naproxen. It seems that imitrex, when taken along with naproxen, is more effective than just imitrex. So you can expect to see a coated imitrex tablet in the future. It was asked a couple times why that is any better than just telling patients to take an Advil along with the imitrex tablet, there was more than a little stuttering and searching for a good answer. I'm sure they'll come up with one before it hits the tv ads.

Trexima is being developed as a combination of sumatriptan (Imitrex) and naproxen sodium (a non-steroidal anti-inflammatory drug NSAID) in a single tablet. This is a joint venture between Glaxo and Pozen.

In a Phase II double-blind placebo-controlled study treating 972 patients with an acute migraine, Pozen reported that a version of the combination of a triptan and an NSAID provided a faster onset and longer duration of pain relief compared to the triptan alone or placebo. In the study, 65% of the patients taking the combination achieved pain relief at two hours versus 49% taking a triptan alone or 27% taking placebo.

Assuming a typical FDA review cycle, approval is anticipated mid 2006.

Glaxo and Pozen will continue to investigate the clinical utility of additional formulations such as injection and nasal spray.

HINT: Migraineurs may want to take an over-the-counter Aleve (naproxen sodium) tablet with their Imitrex (sumatriptan).

See: http://www.pozen.com/product/trexima.asp

BB

Title: Re: Trexima
Post by pattik on Feb 24^th, 2006, 2:40pm

Thanks, Bob. I recall on older thread regarding getting some effectiveness from pulverizing the tabs. Do you recall any pros or cons about this?
Pat

Title: Re: Trexima
Post by BikerBob on Feb 24^th, 2006, 3:00pm

on 02/24/06 at 14:40:12, pattik wrote:

Thanks, Bob. I recall on older thread regarding getting some effectiveness from pulverizing the tabs. Do you recall any pros or cons about this?
Pat

I would be very wary about pulverizing Imitrex tablets. An Imitrex injection is only 6mg sumatriptan because it gets in your bloodstream so fast. Imitrex tablets are 50mg or 100mg sumatriptan. Pulverizing an Imitrex tablet may result in an overdose.

BB

Title: Re: Trexima
Post by Dragnlance on Feb 24^th, 2006, 4:38pm

Quote:

a new imitrex tablet that is coated with naproxen.

ohhh goody, some other poison pill I have to watch for.... allergic to naproxen.... we all know how the docs like to push the new stuff, even if it doesn't work...

Dragn

Title: Re: Trexima
Post by Pinkfloyd on Feb 24^th, 2006, 6:21pm

on 02/24/06 at 16:38:54, Dragnlance wrote:

ohhh goody, some other poison pill I have to watch for.... allergic to naproxen.... we all know how the docs like to push the new stuff, even if it doesn't work...

Dragn

Comments:
1. People that use the jabs *may* want to consider preloading (taking an Aleve before the shot, as early as possible) Sumatriptan is Sumatriptan so if it helps with the tabs, it should help with the injections, although we know the timing issues with clusters.
I wouldn't do this often though.....
2. Since NSAIDs are implicated in rebound headache activity, you don't want to add this problem upon your cluster problems.
3. I see this rebound problem rearing it's ugly head for migrainers in the future with this new proposed combination. Doctors are being instructed to tell their migraine patients to continue to repeat dosages of this new pill just as they are told to do now if the first tablet of Imitrex does not knock out the migraine. Just as some cluster people use quite a few injections per month, some migrainers use quite a few tablets. Taking this many NSAIDs per week will IMHO, add rebounds to people that are not currently having to deal with this problem.
4. How do I see this relating to/effecting cluster sufferers? Many spend years misdiagnosed as migrainers. Add rebounds to their mix and they'll spend even longer periods of time being misdiagnosed. Now as migrainers with rebound headaches.
5. Yes, I suspect the tablet to be advertised as the most effective sumatriptan tablet and will be in competition with the older formulation coming out as a "lowly" generic. Many headache docs don't like prescribing generics so watch for insurance co. problems to increase also.

Bobw

Title: Re: Trexima
Post by MJ on Feb 24^th, 2006, 9:35pm

on 02/24/06 at 14:32:42, BikerBob wrote:

In the study, 65% of the patients taking the combination achieved pain relief at two hours versus 49% taking a triptan alone or 27% taking placebo.

BB

The combination doesnt seem to show any added benefits for clusters unless they last over 2 hours.

I think that Aleve, Naprosyn, Naproxen sodium are good for migraines and lasting shadows though.

Unfortunately they can cause rebound effects for me and CH.

The combo just seems like a marketing deal to me. Like selling shredded lettuce with carrots.

Title: Re: Trexima
Post by thebbz on Feb 28^th, 2006, 8:08pm

;) Make a pill that causes rebounds and another that cures them. What a way to ensure strong sales. No marketing needed. Reminds me of a snake eating his own tail. And around and around [smiley=laugh.gif]
Good info..
jb

Title: Re: Trexima
Post by StressFree on Apr 10^th, 2006, 3:29pm

Perhaps the goal (and effect?) is to give a drug that stops a cluster attack and the other drug keeps it from breaking through again. Aleve is said to last for 12 hours. Like Ibuprofin and the other NSAIDs there are limits to how much a person should take. I always take Aleve for shadows and sometimes in hopes of staving off a cycle. I've gone up to 6 years between cycles. Not sure why so long, but I do Thank God for it! Rich