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        Cluster Headache Help and Support >> Cluster Headache Specific >> CH Theoretical questions?
        
(Message started by: MJ on Feb 1^st, 2006, 1:42pm)

Title: CH Theoretical questions?
Post by MJ on Feb 1^st, 2006, 1:42pm

Have had CH a long time.

Medications and 02 that most sufferers use for control of CH dont work for me.

What has worked to some extent or another for me in the past is natural adrenaline, high dose prednisone, ephedrine, and now LSA (wich I used a little differently than others).

The mechanism theories regarding CH treatments, wether it be blood thinning, serotonin receptor blocking, Nerve blocks or nerve treatments etc.etc.. dont theoretically stand up when these other treatments like psylocin and LSA can and do create long lasting effects with single doses.

The effects can range from a reduction in pain or duration to complete removal of a CH cycle.
If it was a receptor blocking issue I would think that complete and total relief would not be lasting for some as the LSA (or) would wear off and CH would return asap.

Secondly how would this explain the extended reductions in pain, duration and frequency, Yet still having CH. Can the receptors leak or only be partially blocked?

Can serotonin et al be measured in a cup for instance? Can this chemical be tested in direct relation to other chemicals as to neutralyzing or the changes in its makeup?

The theory of the hypothalmus is just that a theory as well, though it seems known to play a definate part in CH. What part cannot be said with certainty.

I may have missed the answers along the way. Some of you may have deeper knowledge, facts or additional theories.

Would be open to any and all thoughts. Perhaps these questions are valid and maybe not.

MJ

Title: Re: CH Theoretical questions?
Post by floridian on Feb 1^st, 2006, 5:17pm

on 02/01/06 at 13:42:33, MJ wrote:

If it was a receptor blocking issue I would think that complete and total relief would not be lasting for some as the LSA (or) would wear off and CH would return asap.

Secondly how would this explain the extended reductions in pain, duration and frequency, Yet still having CH. Can the receptors leak or only be partially blocked?

It isn't just temporarily blocking the receptor - that would wear off as soon as the chemical was cleared from the body. Clusterbusters use the term 'reboot' or 'reset' of the neuroreceptors. Another way to think about it is that it causes short term stimulation of the 5-ht2 receptors, but long term it turns them down.

The receptors get turned down for a period of months, but that only supresses the clusters (or the serotonin triggering of the clusters). It seems that some people have mutated serotonin receptors, or some other factor that causes those particular 5-ht2 receptors to be too many, or too strong, or too easily triggered. And eventually, the med wears off and the 5-ht2 part of the system becomes overbearing. It wouldn't be good if clusterbusters led to a permanent and complete blockage of 100% of those receptors - it turns them down, and eventually wears off.