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Title: Imitrex Post by Unlucky on Jun 17th, 2005, 8:21pm What is the maxium number of times per day (24hrs) that you can safely use Imitrex ? |
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Title: Re: Imitrex Post by Gator on Jun 17th, 2005, 11:23pm According to the data sheet included with the medication - 2. Editted to add: Anything other than that, I would check with your physician. He knows your medical history, current physical condition and current medications. Too many variables involved for anyone here to recommend you use more, even though some will tell you they use much more than the recommended maximum. |
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Title: Re: Imitrex Post by Bob_Johnson on Jun 18th, 2005, 7:07am Headache. 2004 Feb;44(2):178-82. Frequent triptan use: observations on safety issues. Robbins L. Department of Neurology, Rush Medical College, Chicago, Ill. 60062, USA. OBJECTIVE: To examine the safety of frequent triptan use over extended periods. For a small group of patients with refractory migraine plus chronic daily headache, triptans are effective. METHODS: This retrospective study primarily evaluated the cardiac safety of daily triptan use in 118 patients and, in addition, hematologic tests were assessed. Each patient had utilized a triptan for a minimum of 4 days per week for at least 6 months. Patients with rebound headache had been withdrawn from the triptans. Most patients (97 of 118) averaged 1 tablet daily; most would occasionally go for several days without a triptan. Forty patients had taken a triptan for 6 months to 2 years, 37 patients from 2 to 4 years, and 41 for 4 or more years. RESULTS: Routine hematologic tests were performed periodically on all patients, and no abnormalities were attributable to triptans. Almost all patients had an electrocardiogram, and no abnormal electrocardiograms were felt to be related to triptans. Cardiac echocardiography was performed in 57 patients. The 10 abnormal echocardiograms were not due to triptans. All 20 cardiac stress tests revealed normal findings. Adverse events were minimal; 9 patients described fatigue due to triptans, and 5 had mild chest tightness. CONCLUSION: This long-term study of 118 patients indicates that frequent triptan use may be relatively safe. PMID: 14756859 [PubMed - indexed for MEDLINE] --------------------------------- Funct Neurol. 2000 Jul-Sep;15(3):167-70. Related Articles, Links Sumatriptan overuse in episodic cluster headache: lack of adverse events, rebound syndromes, drug dependence and tachyphylaxis. Centonze V, Bassi A, Causarano V, Dalfino L, Cassiano MA, Centonze A, Fabbri L, Albano O. Dept of Internal Medicine and Public Medicine, University of Bari, Italy. This observational study was designed to examine the pattern of sumatriptan use in patients with cluster headache using more than the recommended daily dose of subcutaneously injected (s.c.) sumatriptan. Thirteen patients suffering from episodic cluster headache were asked to record the characteristics of their attacks and drug intake for 1 year. All reported a high daily frequency of attacks (more than 3 per day) and the related overuse of s.c. sumatriptan. The results show that the overall incidence of adverse events among patients receiving sumatriptan injections for the treatment of cluster headache is low. The extended administration of this drug in episodic cluster headache did not result in tolerance problems or tachyphylaxis. Only 4 patients experienced minor adverse events and recovered more slowly than the others. They suffered from migraine without aura and cluster headache, and showed a family history of migraine. Even though they must be viewed with caution, due to the observational nature of the study and the low number of patients included, these results suggest that the profile of sumatriptan may differ in cluster headache compared with migraine. PMID: 11062845 [PubMed - indexed for MEDLINE] |
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