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        New Message Board Archives >> 2005 Cluster Headache Specific Posts >> Re: question if anyone knows
        
(Message started by: BobG on Jun 4^th, 2005, 11:18am)

Title: Re: question if anyone knows
Post by BobG on Jun 4^th, 2005, 11:18am

For me, no. I am the only one that was chosen for this adventure.
But, yes we have had some folks say there are others in their family that are enjoying the trip with them. These c'head families are few compared to the total number world-wide.

Title: Re: question if anyone knows
Post by Karla on Jun 4^th, 2005, 12:18pm

my son has ch as well as I do. According to recent studies there is no heriditary factor. Although I have heard of a few cases where that wasn't the case. But for the majority it just isn't there.

Title: Re: question if anyone knows
Post by Redd715 on Jun 4^th, 2005, 1:19pm

My maternal grandmother and great grandmother both had CH. I'm Chronic, no other family members have CH that we are aware of, but there are many with migraine. My ex husband is episodic CH and there is no other family history of CH in family that they are aware of, but there are a few with migraine.

There were some numbers tossed out last year at convention by the NECH doctor who spoke about hereditary factors, I think the number was 18% but do not quote me on that.

I strongly *feel* that there is a factor in some cases, and what those implication could be when it comes to my two children does have me concerned. Having TWO parents with CH *may* increase their risks of developing this disease. However their Mother will be very well informed and their greatest advocate in the event they do get this.

Title: Re: question if anyone knows
Post by bnfreeman on Jun 4^th, 2005, 8:13pm

I asked one of my neuros one time what the cause of my HAs where and he said genetics/hereditary. But I am the only one in the family with them.

BF

Title: Re: question if anyone knows
Post by pubgirl on Jun 4^th, 2005, 11:15pm

Karla

No idea what your research is, but the research so far here is (and I think it is the most comprehensive gene based reserach underway) that sadly it almost definitely DOES have a hereditary factor but believed that this combines with "other factors" as yet not fully defined (probably lifestyle ones) to cause it to manifest.

Wendy

Title: Re: question if anyone knows
Post by Kevin_M on Jun 5^th, 2005, 1:15am

on 06/04/05 at 11:05:38, cazman wrote:

is this hereditory

Trying to remember, listed guest speaker at 2004 Nashville Convention, Dr. Volcy MD, mentioned something like 6-7% possibility.

Title: Re: question if anyone knows
Post by BarbaraD on Jun 5^th, 2005, 6:57am

I remember the doc saying something about inherited ch, but didn't remember the %.

My grandmother, father and son have migraines, but so far I'm the only one lucky enough to have ch. I just recently started having migraines also. I'm just so lucky!!!!

Hugs BD

Title: Re: question if anyone knows
Post by zebb37 on Jun 5^th, 2005, 8:30am

my father had ch's too

Title: Re: question if anyone knows
Post by Redd715 on Jun 5^th, 2005, 3:22pm

on 06/05/05 at 01:15:56, Kevin_M wrote:

Trying to remember, listed guest speaker at 2004 Nashville Convention, Dr. Volcy MD, mentioned something like 6-7% possibility.

Right Kevin, it was Volcey who was the speaker, however the 6-7% seems to me to be one of percentages he mentioned of the course of manifestation/ progression of this disease? I don't recall everything...I got to the hotel just in time for his presentation with the fiasco with my two canceled flights etc...it was all very overwhelming with what it took just to get there, and I didn't have a notebook to take notes. You may very well be correct.

Title: Re: question if anyone knows
Post by alleyoop on Jun 5^th, 2005, 3:32pm

Hi Cazman,

I'm diagnosed chronic and have two brothers diagnosed episodic. Our paternal grandmother used to have headaches that were so severe that she used to tie cayenne peppers around her head. Although never diagnosed, I'm betting there's a pretty good chance it was CH.

As far as research goes...

If a close blood relative has clusters, your risk is 5x to 20x greater of getting clusters. There is a genetic factor. Genetics also predict the response to lithium and other preventives - if a med helps one person, it is likely to help their blood relatives.

Quote:
Lancet Neurol. 2004 May;3(5):279-83. Epidemiology and genetics of cluster headache. Russell MB. Department of Neurology, Akershus University Hospital, Oslo, Norway. m.b.russell@klinmed.uio.no Cluster headache, the most severe primary headache, is characterised by unilateral pain, ipsilateral autonomic features, and, in many cases, restlessness. Recent epidemiological studies indicate that the prevalence of cluster headache is about one person per 500. Genetic epidemiological surveys indicate that first-degree relatives are five to 18 times-and second-degree relatives, one to three times-more likely to have cluster headache than the general population. Inheritance is likely to be autosomal dominant with low penetrance in some families, although there may also be autosomal recessive or multifactorial inheritance in others. To date, no molecular genetic clues have been identified for cluster headache. Identification of genes for cluster headache is likely to be difficult because most families reported have few affected members and genetic heterogeneity is likely. Future focus should be on ion channel genes and clock genes. This review summarises the epidemiology and genetics of cluster headache.

Quote:
Headache. 1994 Jul-Aug;34(7):400-7. Inheritance of cluster headache and its possible link to migraine. Kudrow L, Kudrow DB. California Medical Clinic For Headache, Encino 91436. We evaluated the possibility that cluster headache may be a transmitted disorder, influenced by migraine genetics. In the first part of a two part study, 24 female cluster headache probands having at least one first degree relative with cluster headache were evaluated for familial histories of cluster and migraine headache. Headache histories of most parents, siblings and children were satisfactorily documented by either direct interview or by information provided by knowledgeable relatives. In approximately a third of relatives, the headache history could not be properly ascertained. The second part of the study evaluated occurrence rates of cluster and migraine headaches among first degree relatives of 200 female and 100 male cluster headache patients, and the proportion of affected relatives. These data were compared to those of 200 women and 100 men with migraine headache; family history data were, for the most part, provided by headache patients. Twenty-four of two hundred cluster headache women (12%) had at least one first degree relative with cluster headache. Three generations of cluster headache were found in 7/24 kindreds (29.17%). Parental cluster headache was found in 19 of the 24 probands (79.17%); in 14/19 (73.68%), transmission was from father to proband. fifty percent of cluster probands also had migraine headaches, and almost 50% had a family history of migraine. Similarly, of the larger population of 300 cluster patients, approximately 45% had a positive family history of migraine. f 1652 relatives of all cluster patients, 3.45% had cluster headache (thirteen times the expected frequency of cluster headache in the general population) and 17.55% had migraine headaches.

................alley