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        New Message Board Archives >> 2005 General Board Posts >> Genetic family cluster data
        
(Message started by: srjeffers on Aug 19^th, 2005, 9:06pm)

Title: Genetic family cluster data
Post by srjeffers on Aug 19^th, 2005, 9:06pm

I believe I have ananswer to the heredity of clusters and why they are so sporadic in families. My wife has suffered from clusters for 15 years with pregnancy interrupting the process altogether.

It is now coming to light for us that her father and his brother are also sufferers. Therefore the most logical explanation is that cluster headaches are a phenomenon of a recessive sex-linked trait. For those unfamiliar... sex-linked traits are from the X chromosome... Mommy of course has two and in all most likelihood is blessed with a dominant. Male offspring receiving an unprotected X (recessive) by virtue of no match (only the Y) inherit the trait. Females are almost always protected.

The unlucky women, like my wife, got the double whammy (two recessives) and if my theory holds water my son is going to be a sufferer too. So as a non-sufferer it is as vital to me as any that a solution be found. Narrowing down the genetic trait to a chromosome is huge... If we have that the haystack shrinks significantly and maybe we can figure out how to deactivate or disable this beast.

My question now: Is this news or not? I have seen no other discussions yet.

Title: Re: Genetic family cluster data
Post by LeLimey on Aug 20^th, 2005, 6:00am

Can you re post this under the current topics at the top of the board please so more people see this?
There are currently two genetic studies underway, one in the US and one in the UK which I will dig out some more data on and post for you. Its of particular interest to me as I am a female sufferer with a son of 3 recently diagnosed with CH.
Can you post it under cluster headache specific at the top of the board please?
Thanks alot
Helen

Title: Re: Genetic family cluster data
Post by aggiegran on Sep 15^th, 2005, 11:14pm

This I have heard, but in my case I can't verify, the only thing I know about my parents is one was a woman and the other a man, (if I was younger I would even doubt that)...So I can't be any help but keep on keeping on.... >:(