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        New Message Board Archives >> 2004 Posts >> New Class of Abortives in the Works
        
(Message started by: Lizzie2 on Apr 13^th, 2004, 8:29am)

Title: New Class of Abortives in the Works
Post by Lizzie2 on Apr 13^th, 2004, 8:29am

Hi y'all,

I'm sure that I remember seeing Floridian or someone post on CGRP receptor medications and their use for cluster headache, but I just found this article on the about.com headache site this morning, and I thought I would pass it along!

http://headaches.about.com/cs/druginfo/a/cgrp_intro.htm

Lizzie :)

Title: Re: New Class of Abortives in the Works
Post by Luke63 on Apr 13^th, 2004, 8:32am

Thanks lizzie..I'll read it when I get a break at work.

Title: Re: New Class of Abortives in the Works
Post by Kevin_M on Apr 13^th, 2004, 8:57am

Lizzie,

Thanks, as some of us get older the transition to newer products like this, if it is effective for clusters, which it may seem to be, may become more important because of the advantage of a decreased risk on the cardiovascular system.

Probably a quite a while before it's approval.

Thanks Lizzie, wish my doctor read recent peroidical articles about these things.

At this point in its development, it will have to face lots of scrutiny of research and studies, but it looks promising.

Kevin M

Title: Re: New Class of Abortives in the Works
Post by pubgirl on Apr 13^th, 2004, 2:35pm

Goadsby September 2003

CGRP
The whole area of CGRP (Calcitonin Gene-Related Peptide) is conversely very promising. One of the biggest problems we have with current treatments is that while they are very good and while they work very quickly, they also have actions on blood vessels that are probably not necessary. People who have high blood pressure and high cholesterol and who are at risk
of heart problems and / or stroke, cannot take triptans because of the actions they are known
to have on blood vessels.
We have recently discovered that the chemical known as CGRP is released by the nerves that
are activated in a migraine attack. Triptans work by cutting off this release. Logically,
stopping the effect of CGRP would have the same end result as stopping its release - no pain.
The idea for the future therefore is to develop treatments that don’t actually block CGRP's
release but which instead neutralise its effect. This has the advantage of greater targeting. By
doing this, we are cutting out all the actions on blood vessels that usage of the triptans leads to. Constricting blood vessels is not necessary. This has been shown as recently as last week at the IHS bi-annual conference in Rome. It is now likely that there will be a CGRP agonist
drug on the market within 4 or 5 years that will not constrict blood vessels like the triptans. That will be a big step forward in migraine treatment. The drugs will be available for a wider market and will also be perceived as ‘safer’ although triptans are themselves extremely safe and reliable.
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Also spot a familiar name in the sponsored links on that article anyone? ;;D

Wendy