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        New Message Board Archives >> 2003 Posts >> Cluster anomoly
        
(Message started by: CJohnson on May 29^th, 2003, 2:19pm)

Title: Cluster anomoly
Post by CJohnson on May 29^th, 2003, 2:19pm

Lately I have been wading through a veritable sea of information about CH which I've found in the post archives, the OUCH website and other places on the internet.

Here is what I think I've learned so far. Please correct me if you notice I am wrong about something.

An irregularity in the hypothalamus generates an anomaly in some aspect of circadean rhythm which causes serotonin modulation to become unstable. Somehow, some aspect of this serotonergic instability stimulates the trigeminal nerve. Thus activated, C-fibers within the trigeminal nerve release vasoactive neuropeptides (such as cytokines), calcitonin gene-related peptide (CGRP), substance P (SP) and neurokanin A, The released CGRP causes the trigeminal nerve to activate again and the blood vessels to dilate abnormally. Some element of this mechanism generates (or fails to prohibit) signals which travel, unmodulated by the spine, through a system of neurons to a part of the brain, which interprets them as CH pain.

PFDANs
-Curtis

Title: Re: Cluster anomoly
Post by don on May 29^th, 2003, 3:30pm

Yup, thats it alright. :-/

Title: Re: Cluster anomoly
Post by Miklos on May 29^th, 2003, 7:43pm

Curtis, now that you know this (which -I- could have quoted from memory), what the dickens are you going to do about it?

Regretfully, knowledge does not help at 2:00 AM with the MFSOB.

Title: Re: Cluster anomoly
Post by suzy617 on May 29^th, 2003, 7:49pm

All I know about CH is that it hurts like hell!

suzy :-*