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Topic: Mangosteen / Xanthone update (Read 1026 times) |
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floridian
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Was pouring through a few hundred abstracts on histamine and serotonin for a newsletter article, and came across one I didn't see during the previous discussion on Mangosteen juice. One of the ingredients that is fairly unique to that fruit is a potent serotonin 5-HT2 antagonist - putting it in the same category as kudzu. This research "narrowed it down" to the serotonin-2A receptor, although they didn't test it for 5-HT2C, only -1, -2A, -2B, and -4.
Quote: Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31.
Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
Chairungsrilerd N, Furukawa KI, Ohta T, Nozoe S, Ohizumi Y.
Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Gamma-mangostin, purified from the fruit hull of the medicinal plant Garcinia mangostana caused a parallel rightwards shift of the concentration/response curve for the contraction elicited by 5-hydroxytryptamine (5-HT) in the rabbit aorta (pA2 = 8.2) without affecting the contractile responses to KCl, phenylephrine (alpha1) or histamine (H1). The perfusion pressure response of rat coronary artery to 5-HT (5-HT2A) was reduced concentration dependently by gamma-mangostin (IC50 = 0.32 microM). 5-HT amplified, ADP-induced aggregation of rabbit platelets (5-HT2A) was inhibited by gamma-mangostin (IC50 = 0.29 microM), whereas that induced by thrombin was not affected, nor did gamma-mangostin affect 5-HT-induced contraction of the guinea-pig ileum (5-HT3)in the presence of 5-HT1, 5-HT2 and 5-HT4 receptor antagonists. Furthermore, 5-HT-induced contraction of the rat fundus (5-HT2B) and 5-HT-induced relaxation of the rabbit aorta in the presence of ketanserin (5-HT1) and carbachol-induced contraction of the guinea-pig ileum (muscarinic M3) were not affected by gamma-mangostin (5 microM). Gamma-mangostin inhibited [3H]spiperone binding to cultured rat aortic myocytes (IC50 = 3.5 nM). The Kd for [3H]spiperone binding was increased by gamma-mangostin (3 nM) from 11.7 to 27.4 nM without affecting Bmax. These results suggest that gamma-mangostin is a novel competitive antagonist, free from a nitrogen atom, for the 5-HT2A receptors in vascular smooth muscles and platelets.
PMID: 9459569 [PubMed - indexed for MEDLINE] |
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Still not selling it; still haven't even tried it, but there is some basis to believe it may have a preventive effect. If I were to buy it, it would be from my local wharehouse club, which has it for about 1/2 the price that the MLM people sell it for.
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| « Last Edit: Dec 20th, 2005, 7:10am by floridian » |
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nani
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Re: Mangosteen / Xanthone update
« Reply #1 on: Dec 20th, 2005, 10:05am » |
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Thanks for that, Jonathan. 
We all appreciate the amount of work you put into your research. You never know... it could just be the next kudzu.
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jckgales
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Re: Mangosteen / Xanthone update
« Reply #2 on: Dec 21st, 2005, 9:14am » |
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Jonathan,
Yes, thanks for your research , Doubt that anyone cares but I'm still doing great on the mangosteen as long as i take it regular.
Jackie Gales
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