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Topic: Melatonin--confirmation of benefits (Read 380 times) |
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Bob_Johnson
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Melatonin--confirmation of benefits
« on: May 25th, 2005, 9:57am » |
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Cephalalgia. 2005 Jun;25(6):403-11.
Melatonin, the pineal gland and their implications for headache disorders.
Peres M.
Brain Research Institute, Albert Einstein Hospital, Sao Paulo, Brazil.
Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia 2005. London. ISSN 0333-1024There is now evidence that melatonin may have a role in the biological regulation of circadian rhythms, sleep, mood, and ageing. Altered melatonin levels in cluster headache and migraine have been documented. Melatonin mechanisms are related to headache pathophysiology in many ways, including its anti-inflammatory effect, toxic free radical scavenging, reduction of proinflammatory cytokine up-regulation, nitric oxide synthase activity and dopamine release inhibition, membrane stabilization, GABA and opioid analgesia potentiation, glutamate neurotoxicity protection, neurovascular regulation, serotonin modulation, and the similarity of chemical structure to that of indomethacin. Treatment of headache disorders with melatonin and other chronobiotic agents is promising. A double-blind, placebo-controlled trial shows melatonin is effective in cluster headache prevention, other studies also show benefit in other disorders. Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment.
PMID: 15910564
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Bob Johnson
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Pinkfloyd
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Re: Melatonin--confirmation of benefits
« Reply #1 on: May 25th, 2005, 10:56am » |
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on May 25th, 2005, 9:57am, Bob_Johnson wrote:Cephalalgia. 2005 Jun;25(6):403-11.
A double-blind, placebo-controlled trial shows melatonin is effective in cluster headache prevention, other studies also show benefit in other disorders. Melatonin plays an important role in headache disorders, offering new avenues for studying their pathophysiology and treatment.
PMID: 15910564
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Proof of how slowly these things can progress....
"Melatonin And Cluster Headaches"
In this study, 10 mg of melatonin was administered to half of 20 cluster-headache patients in a double-blind controlled study that lasted 14 days. Headache frequency was significantly reduced in the
melatonin treatment group. Five of 10 people in the melatonin group reported that their attack frequency declined after only 30-35 days of treatment. No patient in the placebo group responded."
Cephalalgia (Vol 16, Issue 7 1996)
9 years later, it offers new avenues 
It is good to see though that "they" are following up on this.
Bob,
Do you know if this was quoting the study from '96 or was this based upon a new study of melatonin and clusters?
thanks,
Bobw
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"Nothing is so firmly believed as what we least know."
"There is no passion so contagious as that of fear."
[Michel de Montaigne
www.clusterbusters.com
www.obscuredview.blogspot.com
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JJA
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Re: Melatonin--confirmation of benefits
« Reply #2 on: May 25th, 2005, 11:45am » |
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I just checked it out. It's the same old '96 paper.
It also mentions this one where melatonin helps two people with chronic refractive CH:
Peres MF, Rozen TD. Melatonin in the preventive treatment
of chronic cluster headache. Cephalalgia 2001;
21:993–5.
Jesse
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Is it illegal because it's dangerous or is it dangerous because it's illegal? Our drug laws are ruining lives.
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floridian
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Re: Melatonin--confirmation of benefits
« Reply #3 on: May 25th, 2005, 5:56pm » |
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Yay for melatonin!!
There are 28 citations on Pubmed that include both "cluster headache" and "melatonin" - though not all are studies, most are lists of therapies that have been used.
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Bob P
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Re: Melatonin--confirmation of benefits
« Reply #4 on: May 25th, 2005, 6:26pm » |
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I tried it this cluster. 9mg / night for 5 or 6 weeks. Didn't do anything (but I may have done it wrong).
I quit taking it this past weekend and I think I'm sleeping better than I did while taking it.
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Mrs. Barlow, I never, and I repeat never, ever pissed in your steam iron.
"SHUT UP HUB!"
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Marc
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Re: Melatonin--confirmation of benefits
« Reply #5 on: May 25th, 2005, 10:20pm » |
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Of course you took it all wrong Bob!
Marc
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Pinkfloyd
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Re: Melatonin--confirmation of benefits
« Reply #6 on: May 26th, 2005, 12:36am » |
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on May 25th, 2005, 10:56am, Pinkfloyd wrote:
"Melatonin And Cluster Headaches"
In this study, 10 mg of melatonin was administered to half of 20 cluster-headache patients in a double-blind controlled study |
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on May 25th, 2005, 6:26pm, Bob P wrote:I tried it this cluster. 9mg / night for 5 or 6 weeks. Didn't do anything (but I may have done it wrong).
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What makes you think you did anything wrong Bob?
Stop beating yourself up like that. 
Bobw
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"Nothing is so firmly believed as what we least know."
"There is no passion so contagious as that of fear."
[Michel de Montaigne
www.clusterbusters.com
www.obscuredview.blogspot.com
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Mr. Happy
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Re: Melatonin--confirmation of benefits
« Reply #7 on: May 26th, 2005, 12:56am » |
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Bob, Bob and Bob.........
Bob (not Bob or Bob) screwed up. He only took 9 mg instead of the directed 10.
I don't know whether to listen to Bob, Bob, or Bob. Melatonin did nuthing for me, unless it made me sleep like crap. Like Bob, but not Bob or Bob.
I'm losing my mind.....
RJ
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May those who don't want any
Have memories of never getting any.
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Bob P
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Re: Melatonin--confirmation of benefits
« Reply #8 on: May 26th, 2005, 7:02am » |
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I'm thinking that since melatonin is an indole that the shrooms probably interfered with the melatonin.
Seriously, even before I was in cycle I would take mel before bed occasionally. 1.5mg would help me sleep. 3mg would interfere with sleep, shorter an more restless sleep. 9mg didn't seem to do anything. Can the cluster brain be that messed up?
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Mrs. Barlow, I never, and I repeat never, ever pissed in your steam iron.
"SHUT UP HUB!"
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Bob_Johnson
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Re: Melatonin--confirmation of benefits
« Reply #9 on: May 26th, 2005, 7:40am » |
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Bob P has it right. A good study reported on Medscape showed that, for sleep, a dose of 0.3mg was best. Using more or less--for sleep--was less effective.
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Bob Johnson
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vig
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Re: Melatonin--confirmation of benefits
« Reply #10 on: May 26th, 2005, 7:48am » |
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You know, if anybody was playing 'Hi Bob' right now, they'd be really drunk.
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never, Never, NEVER quit. -Winston Churchill
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