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Topic: ATACAND (Read 1086 times) |
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catlind
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Okay, got this info from Svenn today, and I would like to get some feedback from everyone especially the resident gurus.
A 45 year old female with chronic clusters - has tried all abortives, all preventatives and transitional drugs with no success. Has been through surgery again, with no success.
By accident a doctor at the drug center came across Atacand and prescribed it (I hope that's right) She is currently taking 32 mg of Atacand (max dose according to RXList) and has been completely pain free for 3 weeks.
Atacand is a blood pressure medication.
Can anyone shed some light on why this particular blood pressure medication has worked (in her opinion miraculously) when others such as verapamil have failed?
Cat
Edited to add the doctor comes from a highly regarded headache center in trondheim.
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| « Last Edit: Feb 14th, 2005, 12:37pm by catlind » |
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floridian
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Well, its labeled a "angiotensin II receptor blocker" although it may be doing other things as well. Some other info about atacand (candesartand) - purely speculative as to how it works at this point.
A direct neuroprotective effect: ?
Quote:
Curr Hypertens Rep. 2004 Aug;6(4):257-66.
Are angiotensin receptor blockers neuroprotective?
Thone-Reineke C, Zimmermann M, Neumann C, Krikov M, Li J, Gerova N, Unger T. Center for Cardiovascular Research (CCR)/Institut fur Pharmakologie und Toxikologie, Campus Charite Mitte Charite--Universitatsmedizin Berlin, Hessische Strasse 3-4, 10115 Berlin, Germany.
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Improved blood flow: ?
Quote: Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1425-32. Epub 2003 Nov 26. ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles. Tiefenbacher CP, Friedrich S, Bleeke T, Vahl C, Chen X, Niroomand F.
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atacand affects several neurotransmitters in the hypothalamus:
Quote:Brain Res Bull. 2001 Apr;54(6):689-94. The differential effect of angiotensin II and angiotensin 1-7 on norepinephrine, epinephrine, and dopamine concentrations in rat hypothalamus: the involvement of angiotensin receptors.
Pawlak R, Napiorkowska-Pawlak D, Takada Y, Urano T, Nagai N, Ihara H, Takada A. |
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Bob P
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Re: ATACAND
« Reply #2 on: Feb 14th, 2005, 2:53pm » |
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Women don't get clusters?
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sandie99
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Re: ATACAND
« Reply #3 on: Feb 15th, 2005, 1:34am » |
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on Feb 14th, 2005, 2:53pm, Bob P wrote:| Women don't get clusters? |
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Bob... 
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The mad viking
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Re: ATACAND
« Reply #4 on: Feb 18th, 2005, 6:46am » |
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Was talking to my GP about atacand today:
What he said was : I would NEVER give out Verap as a preventative for headaches as first option,but ATACAND.Less sideeffects and all tests shows that it work better as preventative then verap.
Main problem as i see it is that ATACAND is NOT reqognized for clustertreatment.
Guess that is one reason because they have started a double blind study on this here
Will be back with more news as i get it.
BTW im off verap now and testing atacand mainly for my bp.Going to the GP next mnth for a resume on atacand
Svenn
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Gator
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Re: ATACAND
« Reply #5 on: Feb 21st, 2005, 5:20am » |
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We're just a bunch of willing guinea pigs aren't we. Always willing to test that next drug that may be the one. Atacand sounds like it has promise. Keep us posted on how the atacand is working for you.
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The mad viking
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Re: ATACAND
« Reply #6 on: Feb 25th, 2005, 12:54pm » |
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My first day on ATACAND folks.
Had to stay of verap for 4 days before starting ATACAND
this weekend im on only 8mg , but from Monday im on my full doze=16mg
Going to a test at the GP on 18/3 to check if everything is OK
Svenn
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The mad viking
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Re: ATACAND
« Reply #7 on: Feb 28th, 2005, 4:04am » |
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Strange but my ch has decreased to MILD shadows now after been on atacand for 5 days today.
Not sure i can blame all that on Atacand though.
I did start the treatment on 8mg/daily
Im on 16mg/daily on that stuff.
No more info,but will post as soon as i get more news
Svenn
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Gator
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Re: ATACAND
« Reply #8 on: Feb 28th, 2005, 6:42pm » |
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on Feb 28th, 2005, 4:04am, Svenn wrote:Strange but my ch has decreased to MILD shadows now after been on atacand for 5 days today.
Not sure i can blame all that on Atacand though.
I did start the treatment on 8mg/daily
Im on 16mg/daily on that stuff.
No more info,but will post as soon as i get more news
Svenn |
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I guess the first real question is how good is this working as compared to Verapamil?
Second question would be what side effects are you having?
The last question you won't be able to help me with, but does anyone know the cost of Atacand in the US?
I'm glad it seems to be working for you, Svenn. This is another thread I'm going to keep watching.
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The mad viking
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Re: ATACAND
« Reply #9 on: Feb 28th, 2005, 7:10pm » |
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on Feb 28th, 2005, 6:42pm, Gator wrote:
I guess the first real question is how good is this working as compared to Verapamil?
Second question would be what side effects are you having?
The last question you won't be able to help me with, but does anyone know the cost of Atacand in the US?
I'm glad it seems to be working for you, Svenn. This is another thread I'm going to keep watching.
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I feel its starts kick in sooner then verap.Had to stay off verap 120X7 verap retard daily for 4 days before starting on atacand
I do NOT have the "sleepy" feeling that verap gave me .None what so ever
And you`re right Gator,i cant help you with the 3 ?
Damn im lucky to live on this side of the pond when its about medication and healthissue
Will post more as soon as i know more
Svenn
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The mad viking
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Re: ATACAND
« Reply #10 on: Mar 6th, 2005, 6:14am » |
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Still no hits so far
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The mad viking
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Re: ATACAND
« Reply #11 on: Mar 10th, 2005, 1:44pm » |
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Still no hits
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E-Double
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Re: ATACAND
« Reply #12 on: Mar 10th, 2005, 9:54pm » |
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so great to hear!!!!
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The mad viking
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Re: ATACAND
« Reply #13 on: May 27th, 2005, 9:21am » |
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Bumping to tell you all still no hits.None what so ever
Svenn
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PerryGR
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Re: ATACAND
« Reply #14 on: May 28th, 2005, 3:05pm » |
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That's great news Svenn! Thank you for sharing this with us!
PFDAN to all,
Perry.
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Haven't posted in a while so let me re-introduce myself... Male, 25y.o., CCH sufferer for a little bit more than 5 years. Verapamil and Lithium seem to work well at the moment.
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Gator
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Re: ATACAND
« Reply #15 on: May 28th, 2005, 11:38pm » |
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I love hearing about someone being pain free. Means there is still hope for the rest of us schlubs. My next neuro appointment is June 2. Will discuss it with the doc then.
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lionsound
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Re: ATACAND
« Reply #16 on: May 30th, 2005, 8:12am » |
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WOW!!! That's wonderful, Svenn!!!! 
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Giovanni
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Re: ATACAND
« Reply #17 on: May 30th, 2005, 10:03am » |
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Candesartan (Atacand) PREVENTS the constriction of blood vessels. I wonder if it is any conflict with abortives such as imitrex?
John
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magman
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Re: ATACAND
« Reply #18 on: May 30th, 2005, 6:43pm » |
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on May 30th, 2005, 10:03am, Giovanni wrote:Candesartan (Atacand) PREVENTS the constriction of blood vessels. I wonder if it is any conflict with abortives such as imitrex?
John |
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Doc put me on 16mg of Atacand, 150mg x 2 of Lithium (headed to 300mg x2 Tue), Imitrex 6mg (I use only 2mg or 1/3 of a stat dose per attack), and DHE NS.
The Atacand appears to work well with Trex as relief arrives in about 5 to 10 minutes.
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Renee
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Re: ATACAND
« Reply #19 on: May 31st, 2005, 5:07am » |
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Magman,
It's GREAT to hear you are finding some relief. 
I hope your new cocktail continues to work for a long time.
Renee
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javi_spain
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Re: ATACAND
« Reply #20 on: May 31st, 2005, 11:49am » |
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Svenn
Thanks for keeping us updated.
Javier
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Roxy
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Re: ATACAND
« Reply #21 on: May 31st, 2005, 12:02pm » |
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Svenn, I'm so glad you have found relief with Atacand. You deserve it!
I've been on 16mg for the last three weeks, and it doesn't seem to be working for me. I'm going through triptans like candy. Head is breaking through the Amerge and Relpax, Zomig NS will keep me for about 5 hours. After that, I'm getting hit pretty much every hour and a half like clockwork. O2 isn't doing it's thing either for some reason. It's been bad enough that I have readily mixed my triptans......scared the shit out of my family.......  .
I'm calling the neuro today to up the Atacand....I'm going to at least give it a shot at 32mg.
T 
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Margi
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Re: ATACAND
« Reply #22 on: May 31st, 2005, 12:07pm » |
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on May 31st, 2005, 12:02pm, Roxy wrote:It's been bad enough that I have readily mixed my triptans......scared the shit out of my family.......
T |
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Roxy!! Please don't do that! I know you're hurting, honey - but please be careful. BIG hugs - you WILL get through this, you're a strong gal. Please try to back off the med mixing though, ok? Could it be that all those are making things worse for you? Mike really gets a lot more hits when he takes more 'trex. O2 has also failed him at times, too, but he gets to the point you're at, he backs off everything and lets his system rebalance itself for a couple of days and does a water flush. That really seems to help him.
Please, darlin - don't play with fire, ok? 
hugs,
Margi
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| « Last Edit: May 31st, 2005, 12:09pm by Margi » |
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Woobie
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Re: ATACAND
« Reply #23 on: May 31st, 2005, 1:43pm » |
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Roxy.........
I am no one - i dont get clusters..... so i cannot phathom being in so much pain that you would do something you know already almost killed you...
so - dont get mad at me - cuz i really dont GET IT - and I KNOW that I dont....... but dammit....
DONT DO THAT!!!!!!!!!!!
It's been discussed here several times about people's theory that more meds make things worse... but I can see how when you're in the moment - you dont care - you just want it gone. It's a hard place to be in, i'm sure.
Prayin for you Rox.............
Great news for you Svenn!!!!!!!!!!
tina 
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thomas
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Re: ATACAND
« Reply #24 on: May 31st, 2005, 1:49pm » |
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on May 31st, 2005, 1:43pm, Woobie wrote:| when you're in the moment - you dont care - you just want it gone. It's a hard place to be |
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That's exactly how it can be. 
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Religion and sex are powerplays. Manipulate the people for the money they pay. Selling skin, selling God, the numbers look the same on their credit cards. Triptans cause rebounds. Learn it, believe it, live it. I use triptans as the absolute LAST RESORT when treating my CH.
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