Author |
Topic: Does Psilocybin cause vasoconstriction? (Read 6672 times) |
|
PaulL
New Board Newbie
Gender: 
Posts: 40
|
 |
Does Psilocybin cause vasoconstriction?
« on: Dec 18th, 2004, 7:28pm » |
 Quote  Modify
|
I can't take Imatrex any more, the only medication that's ever worked, because I had a heart attack several years ago, so I'm thinking of trying psilocybin. But after reading about it, psilocybin seems to be closely related to Imatrex. Does it cause vasoconstriction? Do you get a rise in blood pressure during use? What's the risk here?
|
|
 IP Logged |
|
|
|
catlind
CH.com Alumnus
New Board Hall of Famer
Taz taught me the cluster dance
  
 
Gender: 
Posts: 3433
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #1 on: Dec 18th, 2004, 7:46pm » |
Quote Modify
|
Paul I'm sure the experts will be along to answer soon, but from what we were told when Roxy had her cardiac event, it does contribute to vasoconstriction.
I'm not sure that I believe this, as it has not ever had a negative effect on Roxy since then.
I'd be willing to bet that using the shrooms together with triptans might be an issue, but I don't believe it is on it's own.
Cat
|
|
IP Logged |
A true friend is someone who reaches for your hand and touches your heart
If yer gonna be stupid, ya gotta be tough
|
|
|
Roxy
CH.com Alumnus
New Board Hall of Famer
Gender:
Posts: 2282
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #2 on: Dec 19th, 2004, 12:12am » |
Quote Modify
|
From what the cardiologist explained, if the shrooms are taken as you are supposed to take them....minus the zomig, imitrex, cigarettes, alcohol, vivarin, coffee,....the effect is negligible.
Taken all together in a short period of time......it's a wild ride!!
T
|
|
IP Logged |
Only two things are infinite, the universe and human stupidity, and I'm not sure about the former. (Einstein)
I used to have a handle on life....but it broke.
|
|
|
forgetfulnot
Guest
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #3 on: Dec 19th, 2004, 4:11pm » |
Quote Modify
 Remove
|
I had a heart attack in 1995, no permanet damage, at any rate Imitrex never came up in my rehab discussions. Never had a heart problem from it since then. And I use a bunch. Sometimes these doctors practice CYA instead of medicine.
Lee
|
|
IP Logged |
|
|
|
Flash
Guest
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #4 on: Dec 20th, 2004, 9:53am » |
Quote Modify
Remove
|
Yes but the effect is VERY mild. Not in anything like the same league as sumatriptan or ergotamine. The dose is also so low that the effect becomes negligible.
In this instance I'd recommend the sip method as the larger doses can cause a little anxiety and that is something you should avoid. The sip doses are so low that there will be no vascular constriction.
The shrooms do not work by constriction, the mechanism is something else entirely.
Please note that O2 is also a vascular constrictor!!!
|
|
IP Logged |
|
|
|
Margi
CH.com Alumnus
New Board Hall of Famer
Nuthin like a good neck rub!
Gender:
Posts: 3757
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #5 on: Dec 20th, 2004, 9:56am » |
Quote Modify
|
Flash, I have a question for you - one I asked you in email but never got a response. It's along the lines of this vasoconstriction question.
If someone is not able to take any of the ergot meds, because of Reynaud's disease, would this also prevent them from using shrooms?
|
|
IP Logged |
http://askusaboutourgrandkids.photosite.com/
And, on the Eighth Day...God created Beer (to stop the Canadians from taking over the world)
source unknown
IMHO (which in my universe is correct)
kathy copelin, ch.com 8/8/06
|
|
|
LeeS
CH.com Alumnus
New Board Hall of Famer
I love C12 H16 N2O!
Gender:
Posts: 588
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #6 on: Dec 20th, 2004, 1:01pm » |
Quote Modify
|
Hi Margi
I'm sure Flash won't mind me jumping in here. The most recent info we have is that shrooms should be avoided if CHers suffer with Reynaud's syndrome (cold-triggered reduction or loss of circulation in fingers and toes) because this condition will be made worse by taking a vasoconstrictor, and mushrooms and LSD are vasoconstrictors.
To what extent it will make it 'worse', I don't know, and I'm sure others will put me right if I'm wrong.
-Lee
|
|
IP Logged |
|
|
|
Margi
CH.com Alumnus
New Board Hall of Famer
Nuthin like a good neck rub!
Gender:
Posts: 3757
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #7 on: Dec 20th, 2004, 1:16pm » |
Quote Modify
|
thanks very much, Lee! I'll pass the info along.
|
|
IP Logged |
http://askusaboutourgrandkids.photosite.com/
And, on the Eighth Day...God created Beer (to stop the Canadians from taking over the world)
source unknown
IMHO (which in my universe is correct)
kathy copelin, ch.com 8/8/06
|
|
|
pinksharkmark
New Board Veteran
Clusterhead
Gender:
Posts: 201
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #8 on: Dec 23rd, 2004, 9:31am » |
Quote Modify
|
Psilocybin is a vasoconstrictor, but a very mild one. The effects are shortlived as well. LSD (being ergot based) is also a vasoconstrictor -- if I recall correctly more so than psilocybin, but again it is mild as vasoconstrictors go. And the effects, though longer lasting than those of psilocybin, are also shortlived.
Should people with Reynaud's Syndrome avoid it? I would guess it would depend on the severity of their case. As has been pointed out already, there are many vasoconstrictors out there. The ones clusterheads typically use (or overuse) being caffeine and nicotine. It's probably not a great idea to "stack" the effects of several vasoconstrictors, but I can't see how using a single mild vasoconstrictor on the very occasional basis that psilocybin is typically taken by clusterheads would throw any but the most severely affected people into any kind of a permanent health crisis.
On the other hand, I don't have a medical degree. My comments above are my personal guesses based on logic and what I have read in the literature on psychedelics. I freely admit that data of which I am currently unaware could change my opinion. Too bad there haven't been more studies in the literature on the interaction of psilocybin with Reynaud's.
pinky
|
|
IP Logged |
|
|
|
Margi
CH.com Alumnus
New Board Hall of Famer
Nuthin like a good neck rub!
Gender:
Posts: 3757
|
|
Re: Does Psilocybin cause vasoconstriction?
« Reply #9 on: Dec 23rd, 2004, 10:15am » |
Quote Modify
|
on Dec 23rd, 2004, 9:31am, pinksharkmark wrote:Too bad there haven't been more studies in the literature on the interaction of psilocybin with Reynaud's.
pinky |
|
Hopefully, Pinky, we'll be able to collect some data on this in the coming years. Thanks for your input, Mark. Merry Christmas to you my misplaced Canadian friend. 
|
|
IP Logged |
http://askusaboutourgrandkids.photosite.com/
And, on the Eighth Day...God created Beer (to stop the Canadians from taking over the world)
source unknown
IMHO (which in my universe is correct)
kathy copelin, ch.com 8/8/06
|
|
|
|
|
|
Home
Help
Search
Members
Member Map
Login
Register
Reply
Notify of replies
Send Topic
Print
test rss