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Topic: octreotide??...help Floridian!!! (Read 333 times) |
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Renee
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octreotide??...help Floridian!!!
« on: Oct 17th, 2004, 11:00am » |
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Quote:Subcutaneous octreotide in cluster headache: Randomized placebo-controlled double-blind crossover study.
Author(s): Matharu M; Levy M; Meeran K; Goadsby P;
Current practical evidence-based acute treatments of cluster headache are limited to subcutaneous and intranasal formulations of sumatriptan, and oxygen. Two small randomized, double-blind trials suggested efficacy of somatostatin in cluster headache. We sought to determine whether octreotide, a somatostatin analog, is effective in the abortive treatment of acute
cluster headache. Patients with episodic and chronic cluster headache, as defined by the International Headache Society, were recruited to a double-blind placebo-controlled crossover study. Patients were instructed to treat two attacks of at least moderate pain severity, with at least a 24-hour break, using subcutaneous octreotide Ī¼g or matching placebo.
The primary end point was the headache response defined as very severe, severe, or moderate pain becomes mild or nil, at 30 minutes. The primary end point was examined using a multilevel analysis approach. A total of 57 patients were recruited of whom 46 provided efficacy data on attacks treated with octreotide and 45 with placebo. The headache response rate with subcutaneous octreotide was 52%, whereas that with placebo was 36%. Modeling the treatment outcome as a binomial where response was determined
by treatment, using the patient as the level 2 variable, and considering period effect, sex, and cluster headache type as other variables of interest, we found that the effect of subcutaneous octreotide 100Ī¼g was significantly superior to placebo (p < 0.01). Subcutaneous octreotide 100Ī¼g is effective in the acute treatment of cluster headache when compared with placebo. Nonvasconstrictor treatment of acute cluster headache is possible. Ann Neurol 2004. |
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Quote:Sandostatin® (octreotide acetate) exerts pharmacologic actions similar to the natural hormone,
somatostatin. It is an even more potent inhibitor of growth hormone, glucagon, and insulin
than somatostatin. Like somatostatin, it also suppresses LH response to GnRH, decreases
splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive intestinal peptide,
secretin, motilin, and pancreatic polypeptide. |
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Floridian,
Can you help explain this?
thanks
Renee
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23 years of battling the beast, 9 years chronic......uneducated docs/nurses make me irate.
The fungus among us is for real!
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floridian
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Re: octreotide??...help Floridian!!!
« Reply #1 on: Oct 18th, 2004, 10:23am » |
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I posted on this a while back - the post dropped to the second page in this section but I'll bump it up - "Octreotide to Abort" is the name of it.
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Renee
CH.com Alumnus
New Board Hall of Famer
May we all find some pf time! Is it summer yet?
Gender:
Posts: 1060
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Re: octreotide??...help Floridian!!!
« Reply #2 on: Oct 19th, 2004, 6:49am » |
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ok, thanks!!! 
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23 years of battling the beast, 9 years chronic......uneducated docs/nurses make me irate.
The fungus among us is for real!
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