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Topic: quercetin (Read 1125 times) |
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custercat04
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After many agonizing nights in June and July, it APPEARS that my quercetin/C/bromelain attack is working - either that, or the suffering is seasonal and this is just a trick. It's very rare now that I have an episode, and when I do it's very mild - still identifiable, for sure. If this IS working, it would appear that the problem, at least for me, must be related to histamine.
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don
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Quote:| must be related to histamine. |
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Most sinus headaches are. You should also try laying down with a towel on your head.
From UC Berkley Welness Guide
Quote:Bottom Line: Despite some promising preliminary studies, it’s too early to recommend quercetin as a supplement. You have no idea what’s in the bottle you buy; there could be little or no quercetin, or excessive amounts. Quercetin absorption can vary, depending on its source. And no one knows what dose should be taken.
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| « Last Edit: Oct 11th, 2004, 10:23am by don » |
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floridian
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Hard to tell with one person in a study. Bromelain has been shown to increase the absorption of the quercetin, which is why they are often taken together. The combo you describe has been shown to help with histamine (which is one component of CH), but also with many other reactions in the body.
Quercetin also affects nitric oxide synthase, ion pumps, PKC, MMP-9, Bcl-2, Bcl-x(L), and the MEK-ERK pathway. Most of these are also affected by lithium, valproic acid, and other preventives - I am not saying that the mode of action is identical, just that the combo described does affect many metabolic pathways that could be related to CH.
Bromelain limits coagulation, reduces T-cell activation (a problem in CH) and reduces PGE2 and substance P (SP is involved in heat/pain sensation and responsible for part of the burning feeling on the affected side).
The Berkeley Wellness page does reccomend increasing quercetin from dietary sources, and mentions green tea, which I have mentioned several times over the past 2 years.
Quote:Pharmacology. 2002 May;65(2):83-6.
In vivo and in vitro effects of bromelain on PGE(2) and SP concentrations in the inflammatory exudate in rats.
Gaspani L, Limiroli E, Ferrario P, Bianchi M.
Department of Pharmacology, University of Milan, Italy.
The effects of bromelain were examined in rats with subcutaneous carrageenin-induced inflammation. After oral in vivo administration, bromelain (10 and 20 mg/kg p.o.) induced a significant decrease of both PGE(2) and substance P concentrations in the exudate. When added to the inflammatory exudate in vitro, the drug (25, 50, 100 microg/ml) did not affect PGE(2) concentrations and induced an increase in the substance P levels. Our data indicate that bromelain reduces the production of two key mediators of inflammation. This effect does not seem to be related to a direct action of the drug on PGE(2) and SP released in the exudate in response to the inflammatory stimulus. Copyright 2002 S. Karger AG, Basel |
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