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Topic: Vioxx recalled (Read 383 times) |
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firebrix
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Vioxx recalled
« on: Oct 1st, 2004, 3:11am » |
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Greetings
We saw on TVNZ news tonight that Vioxx has been recalled and will no longer be prescribed.
I googled "Vioxx recalled" and found this: which is relevant for people in the USA:
http://seattlepi.nwsource.com/business/193272_merck01.html
Didn't seem to work for CH anyway, but it was still prescribed for it here until today.
Thought this might be useful.............
firebrix
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"All that it takes for the triumph of evil is for good men to do nothing."
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E-Double
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Re: Vioxx recalled
« Reply #1 on: Oct 1st, 2004, 8:01am » |
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Read that too! I know there are quite a few poeple who have taken that!
http://www.fda.gov/bbs/topics/news/2004/NEW01122.html
Pain Free wishes,
Eric
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I can't believe that I have to bang my
Head against this wall again
But the blows they have just a little more
Space in-between them
Gonna take a breath and try again.
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floridian
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Yeah, increases heart attack and stroke risk; didn't show up in the short term testing they did to get approval, but after people were taking it for a year or 18 months, the data started piling up.
The big question - do all the Cox-2 inhibitors do the same, or are some without these side effects??
I'll stick to dietary COX-2 inhibitors for now - black cherry juice, turmeric, green tea, etc. Here are some citations on green tea (or ECGC and major tea ingredients) inhibiting Cox-2:
Quote:Free Radic Biol Med. 2002 Oct 15;33(8):1097-105.
Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM.
Int J Cancer. 2004 Sep 28 [Epub ahead of print]
Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells. Hussain T, Gupta S, Adhami VM, Mukhtar H.
J Nutr. 2003 Nov;133(11 Suppl 1):3805S-3810S.
Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells. Kundu JK, Na HK, Chun KS, Kim YK, Lee SJ, Lee SS, Lee OS, Sim YC, Surh YJ.
Biochem Pharmacol. 2001 Nov 1;62(9):1175-83.
Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Hong J, Smith TJ, Ho CT, August DA, Yang CS.
Mutat Res. 2001 Sep 1;480-481:243-68.
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS.
Nutr Cancer. 2000;38(1):60-4.
Suppression of azoxymethane-induced preneoplastic lesions and inhibition of cyclooxygenase-2 activity in the colonic mucosa of rats drinking a crude green tea extract. Metz N, Lobstein A, Schneider Y, Gosse F, Schleiffer R, Anton R, Raul F.
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And tea is protective against heart attack and stroke.
Quote:Am J Clin Nutr. 2002 May;75(5):880-6. Related Articles, Links
Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study.
Geleijnse JM, Launer LJ, Van der Kuip DA, Hofman A, Witteman JC.
Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands.
BACKGROUND: Dietary flavonoids may protect against cardiovascular disease, but evidence is still conflicting. Tea is the major source of flavonoids in Western populations. OBJECTIVE: The association of tea and flavonoid intake with incident myocardial infarction was examined in the general Dutch population. DESIGN: A longitudinal analysis was performed with the use of data from the Rotterdam Study-a population-based study of men and women aged >or=55 y. Diet was assessed at baseline (1990-1993) with a validated semiquantitative food-frequency questionnaire. The analysis included 4807 subjects with no history of myocardial infarction, who were followed until 31 December 1997. Data were analyzed in a Cox regression model, with adjustment for age, sex, body mass index, smoking status, pack-years of cigarette smoking, education level, and daily intakes of alcohol, coffee, polyunsaturated fat, saturated fat, fiber, vitamin E, and total energy. RESULTS: During 5.6 y of follow-up, a total of 146 first myocardial infarctions occurred, 30 of which were fatal. The relative risk (RR) of incident myocardial infarction was lower in tea drinkers with a daily intake >375 mL (RR: 0.57; 95% CI: 0.33, 0.98) than in nontea drinkers. The inverse association with tea drinking was stronger for fatal events (0.30; 0.09, 0.94) than for nonfatal events (0.68; 0.37, 1.26). The intake of dietary flavonoids (quercetin + kaempferol + myricetin) was significantly inversely associated only with fatal myocardial infarction (0.35; 0.13, 0.98) in upper compared with lower tertiles of intake. CONCLUSIONS: An increased intake of tea and flavonoids may contribute to the primary prevention of ischemic heart disease. |
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| « Last Edit: Oct 1st, 2004, 9:48am by floridian » |
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JJA
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Re: Vioxx recalled
« Reply #3 on: Oct 1st, 2004, 10:31am » |
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Floridian,
Early evidence would suggest that you are right, it does appear to be all Cox-2 inhibitors, maybe not to the same extent as Vioxx, however.
Jesse
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Is it illegal because it's dangerous or is it dangerous because it's illegal? Our drug laws are ruining lives.
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eddie
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Re: Vioxx recalled
« Reply #4 on: Oct 1st, 2004, 4:34pm » |
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yea i had my first neuro give me
fking effexor and vioxx
that bastard none of it
worked for me at all
i didnt go back to him
the effexor sucked 
vioxx didnt phase me
PFDAN TO ALL 
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PFDAN TO ALL>><< http://www.putfile.com/ededearl>>><music> http://www.myspace.com/pamneddie
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