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Topic: Fresh Research - Epidemiology & Genetics of CH (Read 270 times) |
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floridian
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Fresh Research - Epidemiology & Genetics of CH
« on: Apr 22nd, 2004, 11:17am » |
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Mostly an overview of existing work. Once case of CH per 500 people (2 per 1000); not sure if this is specific to Norway, or a wider estimate. Genetic component noted although not much is known about the actual genetic mechanism.
The statement "Future focus should be on ion channel genes and clock genes" was interesting. One of the most sucessful prevention regimens is lithium/verapamil. Verapamil blocks calcium ion channels. Lithium has a wide spectrum of action, but it is an unusual ion that definitely affects ion channel activity. Magnesium is also a calcium channel blocker.
Quote:Lancet Neurol. 2004 May;3(5):279-83.
Epidemiology and genetics of cluster headache.
Russell MB. Department of Neurology, Akershus University Hospital, Oslo, Norway.
Cluster headache, the most severe primary headache, is characterised by unilateral pain, ipsilateral autonomic features, and, in many cases, restlessness. Recent epidemiological studies indicate that the prevalence of cluster headache is about one person per 500. Genetic epidemiological surveys indicate that first-degree relatives are five to 18 times-and second-degree relatives, one to three times-more likely to have cluster headache than the general population. Inheritance is likely to be autosomal dominant with low penetrance in some families, although there may also be autosomal recessive or multifactorial inheritance in others. To date, no molecular genetic clues have been identified for cluster headache. Identification of genes for cluster headache is likely to be difficult because most families reported have few affected members and genetic heterogeneity is likely. Future focus should be on ion channel genes and clock genes. This review summarises the epidemiology and genetics of cluster headache.
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