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   Author  Topic: Fresh Research - PNP inhibitors  (Read 284 times)
floridian
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Fresh Research - PNP inhibitors
« on: Apr 20th, 2004, 2:42pm »
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This is basic bio but could be relevant. If so, it is probably years away, but worth thinking about. Also ties into the lymphatoid papulosis thread.
 
A new class of drugs is being developed for treating diseases involving the proliferation of T-cells, including  T-cell leukemias,  psoriasis, rheumatoid arthritis and Crohn's disease.  http://www.eurekalert.org/pub_releases/2004-04/aps-ams041104.php
 
While not listed in that article, cluster headaches may also be respondent to PNP inhibitors.  Cluster heads show pronounced activation of their T-cells.  
 
The PNP enzyme is linked to purine and xanthine metabolism (caffeine is a xanthine).  
 
If nothing else, this will give us one more tool to probe the workings of the beast.
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