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Topic: Fat solubility is important (Read 659 times) |
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CJohnson
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Fat solubility is important
« on: Dec 16th, 2003, 2:02pm » |
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One important difference between sumatriptan (Imitrex) and zolmitriptan (Zomig) is that zolmitriptan is more soluble in fat than sumatriptan. The higher fat solubility means that injected zolmitriptan can be transported more easily through the membranes that divide the blood-vessels from the central nervous system. A greater proportion of the active chemical thereby reaches the places where it works.
Zolmitriptan is also absorbed more easily through the digestive system.
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-Curtis
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pubgirl
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Re: Fat solubility is important
« Reply #1 on: Dec 16th, 2003, 3:22pm » |
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How did you find this out?
That would suggest strongly that a Zomig injectible would be Holy Grail time for speed of abortive wouldn't it?
Wendy
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CJohnson
New Board Old Timer
Cannot kill the family, Battery is found in me
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Re: Fat solubility is important
« Reply #2 on: Dec 16th, 2003, 3:28pm » |
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Here:
http://www.migraeniker.dk/Engelsk/News%20from%20science/medicine.htm
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-Curtis
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Through water and fire. From the lowest dungeon to the highest peak, I fought the Beast. Until at last, I threw down my enemy and smote his ruin upon the mountainside.
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CJohnson
New Board Old Timer
Cannot kill the family, Battery is found in me
Gender:
Posts: 442
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Re: Fat solubility is important
« Reply #3 on: Dec 16th, 2003, 3:35pm » |
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It does seem to imply that. It also implies that Zomig tablets are more orally available and would work faster than imitrex tablets.
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-Curtis
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