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   Author  Topic: Skullcap - Anyone tried?  (Read 307 times)
jminmilwaukee
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Skullcap - Anyone tried?
« on: Sep 23rd, 2003, 1:52pm »
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Anyone with skullcap experience out there? Looking for personal experience, side affect etc.
 
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floridian
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Re: Skullcap - Anyone tried?
« Reply #1 on: Sep 23rd, 2003, 6:26pm »
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I've not used this herb myself, but here is a quick rundown of some of the Pubmed literature on the genus Scutellaria.  This plant has some interesting properties.  Anyone try it?  
 
Contains flavanoids that reduce inflammation, including supression of nitric oxide, tumor necrosis factor alpha, and interleukin-1beta.   (All three actions probably beneficial in clusters - similar action from turmeric, etc).  
 
Inhibits prostaglandin E-2.  
 
Inhibits histamine release. Inhibits Immunoglobin E.  (Good!) (IgE levels significantly higher in cluster heads than regular population.)
 
GABA / benzodiazepene activity.  Flavo-compounds bind to GABA receptors. Reduces anxiety, but lacks the muscle relaxing and sedative properties of valium and other benzo drugs.  
 
Serotonin properties -  binds to HT7 receptors. (others??)  
 
Blocks NMDA nerve receptors in a way compared to Magnesium. (NMDA possibly involved in pain transmission in clusters)  
 
Various anti-cancer, anti-bacterial, and antioxidant properties.  
« Last Edit: Sep 23rd, 2003, 6:28pm by floridian » IP Logged
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