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dannyboy
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Magnesium Cluster Case Report - Japanese Transla..
« on: May 21st, 2002, 6:20am » |
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Magnesium infusion therapy ameliorates intractable cluster headache
H. Kim, K. Shimazu, N. Araki, D. Furuya, C. Takano, T. Shimazu, M. Takahuma & T. Abe
Department of Neurology, Saitama Mediacl School, Japn
Objective: Cluster headaches are intractable because neither high concentration oxygen inhalation nor triptans have been shown to be effective in reducing some of these headaches. A recent report has indicated that the level of serum-ionized magnesium is low in patients with cluster headache. The aim of this study therefore is to examine the effect of magnesium infusion therapy on cluster headaches.
Subjects and methods Four male patients with cluster headaches (41.0 ± 4.8 y.o., means ± SD) that were resistant to the inhalation of high concentrated oxygen received the treatment. The effectiveness of the therapy was then evaluated by the pain scale of six levels (level 5: immobile for pain, level 4: marked limitation of ADL, level 3: moderately painful but mobile, level 2: self-controlled, level 1: minimal, level 0: absent). Magnesium solution (0.5 mol, 20ml) was intravenously administered to the patients for 10 min at the time of maximum level of pain. The informed consents were given by all of the patients.
Results The pain was completely reduced in two patients, who had pain no longer. One patient had the level 1 of pain after the infusion of magnesium. The other got to the level 1 within 20 min after infusion. Nausea and vomiting was found in one patient.
Conclusion Magnesium infusion therapy proves to be effective in dramatically ameliorating intractable headaches that can not be diminished by means of the inhalation of high concentrated oxygen. There is one study that has been reported concerning this therapy. Magnesium infusion will be an innovative therapy for the intractable cluster headache.
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I posted this because I have only seen magnesium studies relating to migraines
Magnesium is cheep and easy ... Check the archives for doses and previous Clusterhead Experiences - quite a few positive, some no improvement.
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| « Last Edit: May 22nd, 2002, 11:02am by dannyboy » |
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BobG
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Re: Magnesium Cluster Case Report - Japanese Journ
« Reply #1 on: May 21st, 2002, 7:11am » |
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hmmmm
50% had no pain. For how long? Until the next attack?
25% had reduced pain. Same questions.
25% had nausea and vomiting.
hmmmm
cheep (dannyboy's spelling, not mine) and easy?
"intravenously administered to the patients for 10 min at the time of maximum level of pain. "
Don't try this a home alone.
www.headachepainfree.com
Shawna’s headache site: (find out about vitamins and minerals Magnesium) Warning: it's a migraine site.
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| « Last Edit: May 21st, 2002, 7:57am by BobG » |
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Drk^Angel
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Re: Magnesium Cluster Case Report - Japanese Journ
« Reply #2 on: May 21st, 2002, 9:27am » |
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It seems to me that a study involving only 4 patients without a control set isn't very much of a scientific study. Looks to me like more research is needed before it can be adequately determined to be an effective treatment, but it may be an interesting path for researchers to follow.
Drk^Angel
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Bob P
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Re: Magnesium Cluster Case Report - Japanese Journ
« Reply #3 on: May 21st, 2002, 11:37am » |
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SERUM IONIZED MAGNESIUM LEVELS (IMg2+) IN 500 PATIENTS WITH HEADACHES
A Mauskop
New York, NY
BT Altura, RQ Cracco, BM Altura
Brooklyn, NY
Serum IMg2+ levels below 0.54 mmol/L predict the response of patients with migraine and cluster headaches to IV infusions of MgSO4. IMg2+ levels are a more sensitive indicator of Mg deficiency than total Mg levels. The objective of this study was to measure IMg2+ in 500 patients with headaches and to correlate IMg2+ with clinical features. All patients presenting to our headache clinic were asked to consent to have blood drawn for IMg2+ measurement. There were 127 men and 373 women; 22 were under 18, 401 between ages 18 and 49, and 77 older than 49. Tension headaches was the main diagnosis in 45 patients, chronic tension headaches in 83, migraine without aura in 208, migraine with aura in 38, chronic daily headache in 81, and cluster headache in 45. IMg2+ was below 0.54 mmol/L in 29% of patients. The only clinical feature that correlated with low IMg2+ was pulsatile quality of pain (P<0.03). These results indicate a high incidence of low IMg2+ in patients with headaches. In a prior study, in patients during an acute migraine attack, we found this incidence to be as high as 53%. The latter patients responded to IV MgSO4. Pulsatile quality of pain may be a useful clinical indicator of low lMg2+.
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Too bad they didn't separatethe clusterheads from the rest.
Also, note the emphasis on "pulsatile" quality of pain as a low Mg indicator. Too bad clusters aren't pulsatile!
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Lee
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Re: Magnesium Cluster Case Report - Japanese Journ
« Reply #4 on: May 22nd, 2002, 12:07am » |
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If I have to go I.V., let's do Demerol instead!
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ave
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Re: Magnesium Cluster Case Report - Japanese Journ
« Reply #5 on: May 22nd, 2002, 7:37am » |
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There's a strange thing there in the description of the experiment.
Look: "Highest pain level: immobile for pain..."
Anyone feel that these are
?
Four subjects... this cannot be a serious scientific project.
Notice also that the source for this article isn't mentioned.
And who the hades did this weird translation?
Do you know what this looks like? One of these leaflets or free magazines trying to sell snake oil alternitive non ebvidence based therapies.
BTW I tried magnesium. Zero!
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ave
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Re: Magnesium Cluster Case Report - Japanese Journ
« Reply #6 on: May 22nd, 2002, 7:39am » |
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There's a strange thing there in the description of the experiment.
Look: "Highest pain level: immobile for pain..."
Anyone feel that these are
?
And four subjects... this cannot be a serious scientific project.
Notice also that the source for this article isn't mentioned.
And who the hades did this weird translation?
Do you know what this looks like? One of these leaflets or free magazines trying to sell snake oil alternitive non ebvidence based therapies.
BTW I tried magnesium. Zero!
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dougW
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Re: Magnesium Cluster Case Report
« Reply #7 on: May 22nd, 2002, 10:51am » |
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"Magnesium infusion therapy proves to be effective in dramatically ameliorating intractable headaches that can not be diminished by means of the inhalation of high concentrated oxygen. "
I thought this was interesting, thanks to Danny and Bob for their articles.
A case study, be it of 1 or 4 people, is a valid scientific study. By definition, it is limited in its applications, but look at the group they were working with, no response to O2 or triptans. If I were in on of those those groups, I'd be considering the treatment.
Note that the magnesium was administered by IV, not tablet or liquid.
Case studies and literature reviews are easier to conduct, less costly and may lead to bigger and better studies. We have to start somewhere.
Doug Wright
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ave
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Re: Magnesium Cluster Case Report - Japanese Trans
« Reply #8 on: May 22nd, 2002, 1:46pm » |
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Four is a big enough group, Doug? Okay, if you say so. The additional info on case studies is very valuable, so maybe I was too fast in my judgement.
But what about "Not moving for pain". Does that sound like clusters? It is the doctors who set these conditions. Ought they not have known about the "dance"?
Also, one of the final sentences reads: "intractible headaches", not intractable cluster headaches.
It makes me wonder again about the translation...
And where was this published?
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dougW
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Re: Magnesium Cluster Case Report - Japanese Trans
« Reply #9 on: May 22nd, 2002, 2:30pm » |
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AAve ;D
You are right about the pain level, but I expect as #4 refers to "marked limitation of ADL" (Activities of Daily Living) that #5 means "can't do anything" That sounds about right for the usual CH!
My point about case studies is that they do not invovle a control group, and may be a sample size of 1, just that, a case study. Case studies can be very valuable, hopefully they will follow this study up with a larger, controlled study.
Many interesting case studies have been done based on 1 or 2 patients, often follow-up or furhter study does not happen, which is truly a shame. Often, the case is no funding for "generic" drugs or treatment, as we all know (too well), the big bucks are in the big name drugs. The money funds the research, and theresearch produces more money.
I hope to present a review of several case studies (literature review) at the Vancouver convention, mainly focused on melatonin.
Further to this thread, I'm going to include a segment on "junk science" and research bias. I'm hoping the reluctance of CH people to sleep during the daytime will keep them from nodding off!!
regards
Ddoug Wright
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DAYSTAR
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Re: Magnesium Cluster Case Report - Japanese Trans
« Reply #10 on: May 24th, 2002, 9:33pm » |
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 I take 700 mg of magnesium a day and 200mg b2 twice a day.Alot of these treatments can help,but only if you clean out yourself of pain meds(especially narcs)
That is not easy,but if the chemicals from all the pain meds are in the way......there is no room for the preventatives to latch on and do their job.I highly reccommend this and nerve blocks for Occipital Neuralgia triggering clusters and migrains.Good Luck everybody.
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Pinkfloyd
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Re: Magnesium Cluster Case Report - Japanese Trans
« Reply #11 on: May 26th, 2002, 1:01am » |
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on May 22nd, 2002, 2:30pm, dougW wrote:AAve ;D
Many interesting case studies have been done based on 1 or 2 patients, often follow-up or furhter study does not happen, which is truly a shame. Often, the case is no funding for "generic" drugs or treatment, as we all know (too well), the big bucks are in the big name drugs. The money funds the research, and theresearch produces more money.
Ddoug Wright
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I'm not a researcher (officially anyway lol) but I would think that most clinical trials and large research projects start based upon 1 or 2 case studies and grow from there.
This is a another report on IV Mg from the same folks that were quoted earlier in the thread.
If some of you can get past the use of the word "migraine", you'll notice that once again a group of cluster sufferers were included. It's studies like this that has lead quite a few specialists in cluster treatment to pick out the cluster data and are currently using the MgIV as a treatment, with good results in some cases.
In many cases, cluster treatments have evolved from research done for migraine headaches first. Once there is some success shown in the treatment of migraines, the testing is expanded to include clusters.
Now, you may say.."why not clusters first?" OK, good question. Here's my take on that.
Migrainers are used as the first lab rats. Following a couple case studies showing some improvement in migraine attacks, there are then studies done to see if it's a feasible treatment for the masses. If good results are shown, cluster specialists and "regular" docs may be inclined to "ask" a cluster patient to try something that has shown some success.
How many cluster sufferers here, or that you know, would be willing to try something that has shown NO effectiveness in treating any type of headache to date, in at least a small clinical trial? How many have? Yes, I've been in some trials but everything I've tried has shown some success with "something" that researchers believe may be related in either pain transmission or physiological changes.
I believe the initial work with shrooms in the headache area was done on migraines. After success was shown, Hoffman moved ahead to clusters.
How many shroom users here would have tried them if someone said to you..on the internet.."try taking some LSD or magic mushrooms the next time you're in the throws of a really bad attack and see what happens. No one has said it works but I just have a feeling"
I know it seems like we're always second in line, but, I think that our pain is so intense that doctors and researchers are hard pressed to try something completely unproven in headache treatment during a cycle. It's bad enough trying something new over and over again, with no results, that does have at least "some" track record.
If you say "bullshit, I'll try anything," I hope you've already tried mushrooms.
How many here using Imitrex would have injected it that first time if there wasn't some track record with migraines?
I don't want to get into some flame war on the subject here. (email would be ok LOL ) and I don't know why I got off on this tangent. I just didn't want people tossing out the baby with the bathwater just because the word migraine appears in a report....found on part two of this post....;-(
BobW
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Pinkfloyd
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Re: Magnesium Cluster Case Report - Japanese Trans
« Reply #12 on: May 26th, 2002, 1:02am » |
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part two.....
just in case you're still reading....
with no further ado...here's something from my FAQ on mag infusion.....
8.4 Magnesium Infusion
"Treating migraine with magnesium"
More complete information can be found at:
http://pharminfo.com/pubs/msb/headache.html
(I don't think this URL is correct anymore)
I know the following report doesn't show statistics on the cluster
sufferers specifically, but many specialists are now trying
magnesium for cluster treatment. This report shows results of
infusion of magnesium through intravenous means, and in attempts
of "breaking" a cycle of headache. . The following information is
published here to explain the reasoning for further study.
Mauskop et al (State University of New York Health Sciences
Center in Brooklyn) recently reported the results of their study of
intravenous MgSO4 for acute headaches. Study participants were 40
consecutive patients (11 men and 29 women) who presented with a
moderate or severe headache of any kind; 16 had migraine without
aura, 9 had cluster headaches, 4 had chronic tension-type headaches,
and 11 had chronic migrainous headaches.
The results were amazing: Complete elimination of pain occurred in
80% of patients within 15 minutes of infusion of 1 gm MgSO4. No
recurrence or worsening of pain was observed within 24 hours in
56% of patients. They found that all the patients had a deficit in the
percentage of Mg that was ionized (Mg++), regardless of whether or
not the patient responded to the MgSO4 infusion. All patients
except tension headache patients had significantly reduced ionized
Mg++ levels. Patients who responded and had no return of headache
or associated symptoms within 24 hours of IV MgSO4 infusion
were those with the lowest baseline levels of ionized Mg++, and
patients with cluster headaches had the lowest basal ionized Mg++
levels of all. Nonresponders had significantly elevated total Mg
levels compared to responders.
In 1985, Altura first proposed that Mg may play a role in the
etiology of migraine headache and may be an effective treatment.
Mg deficiency is thought to make the brain more susceptible to
spreading depression and spreading hypoperfusion. Cerebral blood
vessels are more sensitive to Mg (either excess or deficiency) than
any other type of vascular smooth muscle cell; deficiency
potentiates vasoconstriction, excess potentiates vasodilation. (Lucas
MJ, et al. N Engl J Med. 1995;333:201-205. Lipton RB et al.
Neurology 1994;44:28-32, Ottman R, Lipton RB. Neurol.ogy
1994;44:2105-2110.)
-----
After rereading this, I wonder if taking mag. *pills* after shocking the system with the infusion would give better results than just starting on mag. by mouth, trying to build up one's levels.
it's "mixed" reports like this that lead many cluster people to try taking mag. supplements, some with success.
BobW
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dannyboy
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Re: Magnesium Cluster Case Report - Japanese Trans
« Reply #13 on: May 31st, 2002, 4:13am » |
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The original post that started the thread was published in CEPHALALGIA in 2000 ... jic
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nancyc
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Re: Magnesium Cluster Case Report - Japanese Trans
« Reply #14 on: May 31st, 2002, 8:06am » |
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Thanks Danny...my neuro has mentioned Magnesium...think I may give it a try...why not, i have tried everything else. LOL...
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