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Topic: Predicting response to O2 & triptans (Read 194 times) |
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Bob_Johnson
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Predicting response to O2 & triptans
« on: Jul 25th, 2007, 2:10pm » |
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Headache. 2007 Jul;47(7):1079-84.
Predictors of acute treatment response among patients with cluster headache.
Schürks M, Rosskopf D, de Jesus J, Jonjic M, Diener HC, Kurth T.
Department of Neurology, University of Duisberg-Essen, Essen, Germany.
Background.-Oxygen and triptans are drugs of first choice to abort cluster headache attacks. However, clinical predictors of treatment response are unavailable. Objective.-We aimed to identify predictors of acute treatment response among patients with cluster headache. Methods.-We investigated 246 cluster headache patients with available information on personal, headache, and lifestyle characteristics as well as effectiveness of acute medication use. We used logistic regression models to identify potential predictors of triptan and oxygen response. Results.-Triptans were effective in 137 of the 191 users and oxygen in 134 of the 175 users. WE ONLY IDENTIFIED INCREASING AGE (OR 0.96, 95% CI 0.93-0.99; P= .013) AS A NEGATIVE PREDICTOR FOR TRIPTAN RESPONSE, WHILE NAUSEA/VOMITING (OR 0.41, 95% CI 0.18-0.91; P= .029) AND RESTLESSNESS (OR 0.09, 95% CI 0.01-0.66; P= .019) WERE NEGATIVE PREDICTORS OF OXYGEN RESPONSE. CONCLUSIONS.-FEW CLINICAL FEATURES SEEM TO PREDICT TREATMENT NONRESPONSE IN CLUSTER HEADACHE. MORE REFINED STUDIES AIMING AT PHYSIOLOGICAL AND GENETIC CHARACTERISTICS SEEM PROMISING IN THE FUTURE.
PMID: 17635600 [PubMed]
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Bob Johnson
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thebbz
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Re: Predicting response to O2 & triptans
« Reply #1 on: Jul 25th, 2007, 9:32pm » |
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Again I thank you for the information. It is interesting that the research includes lifestyle characteristics. They sure are interested in our lifestyle??? I dont feel that it is such a prevailing factor as genetics for example, although they may interface.
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thebb
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Re: Predicting response to O2 & triptans
« Reply #2 on: Jul 26th, 2007, 9:22am » |
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Thanks again Bob for the info !
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