Author |
Topic: Serotonin Syndrome (Read 638 times) |
|
lililola
New Board Newbie
I love YaBB 1G - SP1!
Posts: 2
|
 |
Serotonin Syndrome
« on: Jan 16th, 2007, 6:51am » |
 Quote  Modify
|
Triptan-Antidepressant Interaction Causing Serotonin Syndrome
FDA Public Health Advisory
On July 19, 2006, the FDA issued a Public Health Advisory warning of the potential danger associated with the use of 5-hydroxytryptamine agonists (triptans) in patients who are also taking selective serotonin reuptake inhibitors (SSRIs) and selective serotonin/norepinephrine reuptake inhibitors (SNRIs).
http://www.pswi.org/irx/triptan.htm
|
|
 IP Logged |
|
|
|
chewy
Guest
|
ALI!
|
|
IP Logged |
|
|
|
Redd
CH.com Alumnus
New Board Hall of Famer
Gender: 
Posts: 6661
|
|
Re: Serotonin Syndrome
« Reply #2 on: Jan 16th, 2007, 7:39am » |
Quote Modify
|
My first reaction as well....
|
|
IP Logged |
I saw an act of faith today. A man was on his knees, not in a pew in a Church, but in a garden planting seeds. ~~Unknown
|
|
|
nani
CH.com Alumnus
New Board Hall of Famer
Got kudzu?
Gender:
Posts: 7953
|
|
Re: Serotonin Syndrome
« Reply #3 on: Jan 16th, 2007, 8:19am » |
Quote Modify
|
Ali? Maybe.
The warning is real, though.
|
|
IP Logged |
Others may come and go, but MY power is MINE.
|
|
|
George_J
CH.com Alumnus
New Board Hall of Famer
White-Breasted Nuthatch
Gender: 
Posts: 4222
|
|
Re: Serotonin Syndrome
« Reply #4 on: Jan 16th, 2007, 9:15am » |
Quote Modify
|
A search at fda.gov shows the following:
http://www.fda.gov/cder/drug/advisory/SSRI_SS200607.htm
Best,
George
|
|
IP Logged |
Ah! The foreigners put on such airs
Wearing the tangerine suits
And their harlequin eyes.
The pain they inspire
Draws in harmonica melodies
And the feathers of birds
Which flame up at their touch.
It all comes to light in the sheer
Debonair.
(Ellen)
|
|
|
Barry_T_Coles
CH.com Alumnus
New Board Hall of Famer
 
Gender:
Posts: 1348
|
|
Re: Serotonin Syndrome
« Reply #5 on: Jan 16th, 2007, 5:09pm » |
Quote Modify
|
pswi = Pharmacy Society of Wisconsin
|
|
IP Logged |
Worry is like a rocking chair it gives you something to do but gets you nowhere.
http://mushys.com/kiwi
[img]
|
|
|
Ob1kanobee
New Board Veteran
I love YaBB 1G - SP1!
Gender:
Posts: 101
|
|
Re: Serotonin Syndrome
« Reply #6 on: Jan 16th, 2007, 9:49pm » |
Quote Modify
|
What does this mean in Laymans terms?
|
|
IP Logged |
|
|
|
floridian
Guest
|
Be careful about triptans if you take prescription antidepressants. The anti-depressants could amplify the triptans to the point that serotonin syndrome occurs - higher body temperature, grinding jaw, other problems that could be life threatening.
|
|
IP Logged |
|
|
|
Ob1kanobee
New Board Veteran
I love YaBB 1G - SP1!
Gender:
Posts: 101
|
|
Re: Serotonin Syndrome
« Reply #8 on: Jan 16th, 2007, 11:27pm » |
Quote Modify
|
So if I'm taking say Paxil, I can't take an Imitrex injection?
Or rather if i am taking Paxil, I have a higher chance of having a body malfunction if i were to take a shot of Imitrex?
If this is the case, are they not alowing people on anti-depressents to take Imitrex, or do they have to be monitored or something?
|
|
IP Logged |
|
|
|
nani
CH.com Alumnus
New Board Hall of Famer
Got kudzu?
Gender:
Posts: 7953
|
|
Re: Serotonin Syndrome
« Reply #9 on: Jan 16th, 2007, 11:56pm » |
Quote Modify
|
From the FDA link:
Serotonin syndrome occurs when the body has too much serotonin, a chemical found in the nervous system. Serotonin syndrome symptoms may include restlessness, hallucinations, loss of coordination, fast heart beat, rapid changes in blood pressure, increased body temperature, overactive reflexes, nausea, vomiting, and diarrhea. Serotonin syndrome may be more likely to occur when starting or increasing the dose of a triptan, SSRI or SNRI.
The FDA has determined that serotonin syndrome occurs with combined use of triptans and a SSRI or SNRI through reports describing serotonin syndrome in people taking these medications together. Each of these types of medicine increases serotonin levels on its own, as well.
Patients who are taking a triptan along with an SSRI or SNRI should talk to their doctor before stopping their medications.
Physicians prescribing a triptan, SSRI or SNRI should:
keep in mind that triptans are often used intermittently and that either the triptan, SSRI or SNRI may be prescribed by a different physician
weigh the potential risk of serotonin syndrome with the expected benefit of using a triptan with an SSRI or SNRI
discuss the possibility of serotonin syndrome with patients if a triptan and an SSRI or SNRI will be used together
follow patients closely if a triptan and an SSRI or SNRI are used together, particularly during treatment initiation, with dose increases, or with the addition of another serotonergic medication
instruct patients who take a triptan and an SSRI or SNRI together to seek medical attention immediately if they experience the symptoms of serotonin syndrome (described above).
Patients should know which medicines they take and tell all of their healthcare providers (physicians, nurses, and pharmacists) what these medicines are.
Triptans are drugs used to treat migraine headaches, and SSRIs and SNRIs are drugs used to treat depression and other mood disorders.
The FDA has requested that all manufacturers of triptans, SSRIs and SNRIs update their prescribing information to warn of the possibility of serotonin syndrome when triptans and SSRIs or SNRIs are taken together.
|
|
IP Logged |
Others may come and go, but MY power is MINE.
|
|
|
Karla
CH.com Alumnus
New Board Hall of Famer
One of Many and Never Alone - Join OUCH
Gender:
Posts: 3090
|
|
Re: Serotonin Syndrome
« Reply #10 on: Jan 18th, 2007, 5:00pm » |
Quote Modify
|
My dr said antiphycotics and imitrix can cause this problem as well. I am taking 2 antiphycotics and 2 antidepressants. I use imitrix nasal spray 20mg sparingly. Like 4-6x/month or less. So my dr is ok with this.
Now I was for 2 years using 6x/day everyday and had no problem. That was before the warning was issued. So my dr said he wasn't comfortable with that much imitrex use and for me to cut down. Well since I now have a preventative that works for me I don't need imitrex except for my migraines that occurr a few times a month.
Bottom line. Talk to your dr and be aware of potential side effects and risks.
|
|
IP Logged |
Karla
suffer chronic ch
ch.com groupie since 1999
Proud Mom of Chris USMC Semper Fi
|
|
|
mcf69
New Board Old Timer
I am acutely aware of where my trigeminal nerve is
 
Gender:
Posts: 337
|
|
Re: Serotonin Syndrome
« Reply #11 on: Jan 20th, 2007, 11:25am » |
Quote Modify
|
Serotonin syndrome is very real and all taking perscription SSRI's and other anti depressant/anti psychotics should be monitored for symptoms of serotonin syndrome.....
|
|
IP Logged |
|
|
|
gonz2112
New Board Newbie
Gender:
Posts: 30
|
|
Re: Serotonin Syndrome
« Reply #12 on: Jan 21st, 2007, 2:05pm » |
Quote Modify
|
My non-Kaiser neuro is not real easy to get a hold of so I emailed my P.A. at Kaiser about this...
Quote:Subject: Serotonin Syndrone
Since I am on Citalopram and averaging about 1 Imitrex injections per day is this something I should be concerned about?
Triptan-Antidepressant Interaction Causing Serotonin Syndrome - FDA Public Health Advisory
On July 19, 2006, the FDA issued a Public Health Advisory warning of the potential danger associated with the use of
5-hydroxytryptamine agonists (triptans) in patients who are also taking selective serotonin reuptake inhibitors (SSRIs) and selective serotonin/norepinephrine reuptake inhibitors (SNRIs).
http://www.fda.gov/cder/drug/advisory/SSRI_SS200607.htm
----- Message -----
Subject: RE: Serotonin Syndrone
Requiring Imitre daily is way too much. You need some daily preventative medication. I have not seen you since March of last year so scheadule an appointment to decide what we should do.
----- Message -----
Subject: Serotonin Syndrone
Over the past 20 years I have tried most all the preventatives: inderal, lithium, sansert, prednisone, depakote, topamax, and verapamil. All had very little or no noticeable effect on the frequency/intensity of the headaches or the length of the cycles and in most cases the side effects outweighed any benefits.
Given my past experience, the possibility that meds can extend a cycle, and the fact that I am about 7 weeks into what is usually an 8-12 week cycle I am not really interested in trying a preventative. That being said, I am open to suggestion and would certainly like your professional opinion.
As far as my Imitrex usage, I use half an injection per headache and can often abort with oxygen alone. I get about 2-4 headaches per day so some days I use up to 2 injections and there are some days I don't use any. I also have usually one pain free day a week.
Thanks and let me know what you suggest.
----- Message -----
Subject: Serotonin Syndrone
Sounds like you have already been the Gamut of treatments. I guess all we can do is what you are doing now. |
|
So basically if they can't get my $30 copay they just don't care. Nice!
Mark
|
|
IP Logged |
Episodic since 1986 at age 19.
|
|
|
thomas
CH.com Alumnus
New Board Hall of Famer
"Hit like a phillips head into my brain."
Gender:
Posts: 3281
|
|
Re: Serotonin Syndrome
« Reply #13 on: Jan 23rd, 2007, 10:29am » |
Quote Modify
|
on Jan 16th, 2007, 8:19am, nani wrote:Ali? Maybe.
The warning is real, though. |
|
The warning is very real. As one who uses Prozac as part of my preventive regimin, I strongly urge people to use extreme caution when combining these drugs.
|
|
IP Logged |
Religion and sex are powerplays. Manipulate the people for the money they pay. Selling skin, selling God, the numbers look the same on their credit cards. Triptans cause rebounds. Learn it, believe it, live it. I use triptans as the absolute LAST RESORT when treating my CH.
|
|
|
|
|
|
Home
Help
Search
Members
Member Map
Login
Register
Reply
Notify of replies
Send Topic
Print
Remove
test rss