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Topic: Swedish Study: 1 in 500 with Clusters ö (Read 400 times) |
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floridian
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Swedish Study: 1 in 500 with Clusters ö
« on: Oct 25th, 2006, 11:42am » |
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Quote: Neurology. 2006 Sep 12;67(5):798-803.
Lifetime prevalence and concordance risk of cluster headache in the Swedish twin population.
* Ekbom K,
* Svensson DA,
* Pedersen NL,
* Waldenlind E.
Department of Neurology, Karolinska Institutet, Stockholm, Sweden.
OBJECTIVE: To examine the lifetime prevalence and the concordance risk of cluster headache (CH) in a twin sample representative of the Swedish general population. METHODS: The authors assessed CH as defined by the second edition of the International Classification of Headache Disorders in 31,750 registered twins born from 1935 to 1958. Structured lay screening interviews were followed by neurologist interviews of possible cases. Co-twins of affected index twins were follow-up interviewed regardless of their screening outcome. RESULTS: A total of 250 screening-positives (0.8%) were found, of which 218 (88%) were follow-up interviewed. Forty-five (21%) had the CH diagnosis verified. Among screen-negatives, hospitalization records pointed at two more verified cases and index twins at one more verified case. A total of 48 CH cases provided a crude lifetime prevalence of 151 per 100,000 (95% CI: 108, 194). The male-to-female sex ratio corresponded to 4.8 (95% CI: 2.3, 9.9). The crude lifetime prevalence of CH was higher in the twins born from 1945 to 1958 than in the twins born from 1935 to 1944 (190 vs 90/100,000). CH recurred in 2 of 12 co-twins of monozygous index twins (including 1 nonparticipant twin), whereas all co-twins of 25 dizygous index twins proved to be unaffected. CONCLUSION: As many as 1 per 500 of the general population are affected by cluster headache. Twin concordance seems low, but genetic factors may play a role for familial clustering.
PMID: 16966540 [Pu |
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George_J
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Re: Swedish Study: 1 in 500 with Clusters ö
« Reply #1 on: Oct 25th, 2006, 11:57am » |
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So--600,000 in the US alone?  
Seems a little high, but--it's a pretty big study.
Good heavens.
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George
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Ah! The foreigners put on such airs
Wearing the tangerine suits
And their harlequin eyes.
The pain they inspire
Draws in harmonica melodies
And the feathers of birds
Which flame up at their touch.
It all comes to light in the sheer
Debonair.
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floridian
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Re: Swedish Study: 1 in 500 with Clusters ö
« Reply #2 on: Oct 25th, 2006, 12:09pm » |
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600,000 in the US sometime in their life. Many of the ones who have already done their time probably weren´t diagnosed. But lots of people in total if the US population is like the Swedes.
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Charlotte
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Re: Swedish Study: 1 in 500 with Clusters ö
« Reply #3 on: Oct 25th, 2006, 1:39pm » |
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I think it is higher than this, but many of us will never get a clear diagnosis for one reason or another, like having too many types of headache at one time, going out of cycle, or simply by being female.
There are so many undetermined factors in the study. It could genetic with a trigger of injury or chemical exposure, of some type that was less prevalent before 1944.
c
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| « Last Edit: Oct 25th, 2006, 10:20pm by Charlotte » |
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