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Topic: Plasma and Platelet Methionine-Enkephalin Levels i (Read 392 times) |
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marlinsfan
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Re: Plasma and Platelet Methionine-Enkephalin Leve
« Reply #1 on: Jul 24th, 2005, 6:01pm » |
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violet
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Re: Plasma and Platelet Methionine-Enkephalin Leve
« Reply #2 on: Jul 24th, 2005, 6:07pm » |
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Headache: The Journal of Head and Face Pain
Volume 27 Issue 6 Page 325 - June 1987
doi:10.1111/j.1526-4610.1987.hed2706325.x
Plasma and Platelet Methionine-Enkephalin Levels in Chronic Cluster Patients During an Acute Headache Episode
Aron D. Mosnaim , Ph.D. , 1,2 Seymour Diamond , 1,3 Frederick Freitag , D.O. , 3 Jorge Chevesich , B.S. , 1 Marion E. Wolf , M.D. , 2,4 and Glen Solomon , M.D. 1,3
SYNOPSIS
The different phases of an acute headache episode in chronic cluster patients were generally (6 out of 8 subjects) accompanied by rapid, significant changes in platelet-rich plasma (PRP) methionine-enkephalin (MET) levels. In contrast to these findings, platelet MET levels remained fairly unchanged in individual subjects and the observed intergroup variations well within the range of experimental error of the analytical technique used. With each patient serving as its own control we observed that "precluster" plasma peptide levels were substantially higher than their corresponding "during crisis" values, which in turn were higher than the "postcluster" MET concentration. When considered as a group, we showed statistically significant differences between the "pre" and "during cluster" and "pre" and "postcluster" headache phases, but not between the "during" and "postcluster" group of values. Each of these six patients had "precluster" PRP peptide concentration (range 198318 pg MET/ml) above the range of normal controls (n=19, 54126 pg MET/ml) and dramatically higher than their own levels when analyzed approximately six months later; at this time none of the subjects were in a "pro" or "during cluster" headache phase. In the other two patients PRP MET levels were fairly unchanged during the acute headache episode, at levels falling below the x ± 1 S.D. of normal controls.
These results show that, similarly to what has been reported for acute migraine headaches, the "precluster" phase of an acute cluster headache episode is accompanied by significant increases in plasma MET levels. However, and in contrast to migraine, peptide levels decrease rapidly to normal control values ("during cluster" phase), falling even further in the "postcluster" period. These results indicate that cluster patients lack the ability observed in migraineurs to keep a long lasting, sustained increase in plasma peptide concentration, a difference which could prove important for a better understanding of the possible different mechanisms involved in the modulation of the pain response between migraine and cluster headaches, as well as to differentiate biochemically both groups of patients.
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firebrix
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Re: Plasma and Platelet Methionine-Enkephalin Leve
« Reply #3 on: Jul 24th, 2005, 6:18pm » |
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Thank you for posting this violet.
Always interested in research which might lead the way to better understanding of CH.
It may be slow, but it IS happening
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"All that it takes for the triumph of evil is for good men to do nothing."
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