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Topic: VIOXX (Read 1053 times) |
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ex_pat_asia
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"Sometimes the wolves lie down and the Moon howls
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Re: VIOXX
« Reply #25 on: Aug 13th, 2004, 1:56pm » |
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on Jul 30th, 2004, 12:37pm, brokenfingers wrote:
NSAIDS are notorious for the list of side affects at the url. Unless I am foregtting something it looks like the usual litany. Yet, that shouldn't prevent digging deeper into the possibilities here.
Quote: Posted by: floridian Posted on: 07/27/04 at 2:16am
Among other things, melatonin blocks cox2, nitric oxide, and 5-LO (5-lipoxygenase, an inflammatory enzyme similar to cox2). It could be co-incidental, or it could part of how melatonin works. |
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Floridian, it seems to me then that Melatonin would be a better choice then Vioxx as a starting place for Cox2 inhibition? The latter is also getting a bum rap for high blood pressure (see following)
http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=592 7928
For me that would be an issue thus leading me back to the melatonin. I had been thinking on giving melatonin a trial but was drawn to it for reasons of sleep regulation rather then cox2 and 5-LO inhibition. Also, I agree with your connect-the-dots to EPH and Migraine. The following connects two of the dots in a single patient:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed &dopt=Abstract&list_uids=10759906
I'll start the melatonin tomorrow, adding it to the 480 mg verapamil and the Betamethasone taper.
Immigram and Relpax have all but drifted into irrelevancy for me...Oxy is now the only effective aborter. It is a bloody anchor and I need to get back on the road for my business.
Thanks as always Floridian...superb search skills.
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ex_pat_asia
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